Comparison between peritoneal dialysis and hemodialysis on kidney function recovery in incident kidney failure: A nationwide cohort study

Abstract

Background Patients with kidney failure who start dialysis have a chance of kidney function recovery. Whether the initial dialysis modality affects the possibility of recovery is not fully understood. Methods We included patients diagnosed with kidney failure requiring dialysis during 2001–2013 from the Taiwan National Health Insurance Research Database. We excluded diabetic and elderly patients. Kidney function recovery was defined as not receiving dialysis therapy for longer than 3 months. The primary outcome was kidney function recovery, and the secondary outcome was all‐cause mortality during a 3‐year follow up. Results A total of 12,619 patients was eligible for analysis, with 981 received PD and 11,638 received HD. Total 620 patients had kidney function recovery during a 3‐year follow up, which represented 4.9% of the entire cohort. After propensity score matching, the PD groups were more likely to experience kidney function recovery (subdistribution hazard ratio [SHR]: 1.64, 95% confidence interval [CI]: 1.19–2.25). The risk of all‐cause mortality between groups did not significantly differ (hazard ratio [HR]: 1.23, 95% CI: 0.89–1.70). Conclusion The study found that in nonelderly, nondiabetic patients who received inadequate predialysis nephrology care before kidney failure, PD is associated with a higher chance of kidney function recovery.

Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis

“…Our results suggest that after entering the early stage of PD, the serum ELA levels increased in patients with CKD5, corroborating previous results ( Lu et al, 2020 ). Early PD treatment improves residual renal function in some patients with CKD5 ( Kuo et al, 2022 ). We speculate that after patients with CKD5 enter the early stage of PD, the anemia and acidosis of the body will improve to a certain extent, which may promote the transient increase of ELA in the circulatory system.…”

Exploring the Therapeutic Potential of Peritoneal Dialysis (PD) in the Treatment of Neurological Disorders

“…It does not require vascular access or anticoagulants, making it a viable option for patients with HD-related thrombosis 11 or those who are hemodynamically unstable 12 . In addition, PD has been associated with a higher likelihood of renal function recovery 13 , a less complex procedure 14 , and a significant enhancement in the quality of life for patients. This is owing to its flexibility and independence from frequent clinical interventions 15 .…”