Comparison between Oral and Written Spelling in Alzheimer's Disease

Croisile, Bernard; Brabant, Marie-Josee; Carmoi, T.; Lepage, Yves; Aimard, G; Trillet, M

doi:10.1006/brln.1996.0081

Cited by 47 publications

(46 citation statements)

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“…Hence, the profile of spelling impairment present in AD patients is congruent with the deficit described in the oral domain and could be caused by degradation of specific linguistic subcomponents (Croisile et al, 1996;Forbes et al, 2004;Rapcsak et al, 1989). Nonetheless, some authors ascribe it to the general cognitive decline associated to dementia (Aarsland et al, 1996;Glosser & Kaplan, 1989;Silveri, Corda, & Di Nardo, 2007), especially in the cases of peripheral disorders (Neils-Strunjas et al, 1998).…”

Section: Introductionmentioning

confidence: 67%

“…The most common pattern of deficiency includes lexical dysgraphia (Croisile et al, 1996;Forbes, Shanks, & Venneri, 2004;Hughes, Graham, Patterson, & Hodges, 1997;Rapcsak, Arthur, Bliklen, & Rubens, 1989) which may be concurrent with a phonological or sublexical deficit (Aarsland, Hoien, Larsen, & Oftedal, 1996;Luzzatti, Laiacona, & Agazzi, 2003;Neils & Roeltgen, 1994;Pestell, Shanks, Warrington, & Venneri, 2000;Platel et al, 1993) in later stages of the disease. In some cases, peripheral impairments are also present (Forbes et al, 2004;Horner, Heyman, Dawson, & Rogers, 1988;Neils-Strunjas, Shuren, Roeltgen, & Brown, 1998;Venneri, Pestell, & Caffarra, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Neural correlates of spelling difficulties in Alzheimer’s disease

et al. 2014

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Abstract.Alzheimer's disease (AD) is associated with a general cognitive decline that affects the memory and language domains. Thus, an oral production deficit with a lexical-semantic origin has been widely observed in these patients. Their written production capacities, however, have been much less studied. We assessed the spelling abilities of 22 AD patients and a group of matched healthy controls with a test battery including written picture naming and word and pseudoword dictation tests, as well as text dictation and spontaneous writing tasks. The results of the AD patients in the discriminative tasks were then entered into voxel-based morphometry analyses along with their grey matter volumes. The patient group presented a selective impairment for word dictation, which contrasted with a spared capacity to spell pseudowords, and showed more difficulties for words with arbitrary and rule-based orthography. Moreover, they also produced less complete syntactic units in the spontaneous writing task. These results point out the lexical-semantic, as opposed to sublexical, nature of the spelling deficit associated to AD. In addition, we recognized a mainly left-lateralized cortical network, including areas in the posterior inferior temporal lobe and the superior region of the parietal cortex, which might be responsible for this impairment. Other regions, such as the putamen, were also associated to the deficit. The results of this study, hence, improve our understanding of the neuropsychological and neuroanatomical mechanisms that underlie the cognitive symptoms associated to AD.

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Section: Introductionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Neural correlates of spelling difficulties in Alzheimer’s disease

et al. 2014

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“…Dysgraphia occurs during both the earlier as well as the later stages during the clinical course of AD [36][37][38] and is associated with attentional, motor and memory deficits that develop during disorder progression [39]. It has been suggested to be a more sensitive indication of language deficits in AD than anomia [22]. Yoon et al [40] have observed that a sample of 35 patients presenting early onset AD, with a severe degree of hypometabolism in the parietal brain region, exhibited not only linguistic errors but also visuoconstructional manifestations (derived from Hangul scripts) of dysgraphia that were associated with cognitive impairments in multiple domains.…”

Section: Discussionmentioning

confidence: 99%

“…A positive correlation was observed between the severity of the dementia and spelling/writing measures (lexical and allographic). Agraphia or dysgraphia, observed in early AD [22], encompasses a progressive disorganization and degeneration of the various components of handwriting [23]; these include the complexity of the structure of sentences [24], the diversity and the accuracy of words used [25], punctuation [26], organization [25], the production of grammatically incorrect sentences [27,28], the length of the sentences [27], the amount of written information [28], the morphology of the letters [27] and spelling [29], graphic and spatial layout of letters and their arrangement in texts [18]. Fukui and Lee [30] examined the possibility that agraphia/dysgraphia may be an early sign of degenerative dementia, reporting the concurrent or subsequent emergence of non-fluent aphasia, ideomotor apraxia, executive dysfunction and asymmetric akinesicrigid syndrome; these observations implicate degenerative processes involving the parietal-occipital-temporal regions, basal ganglia and striato-frontal projections.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Performance Deficits and Dysgraphia in Alzheimer’s Disease Patients

Archer¹,

Onofri²,

Mercuri³

et al. 2015

MEDJ

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Abstract:Introduction: Agraphia or dysgraphia, observed often in early AD, encompasses a progressive disorganization and degeneration of the various components of handwriting.Methods: Deficits in writing ability, dysgraphia, and the relationship with other measures of cognitive decline were studied in a group of 30 patients, originating from the Lazio region, Rome, Italy, presenting a moderate to relatively severe stage of Alzheimer's disease (AD). Extent of dysgraphia and cognitive performance was compared with a matched group of healthy controls selected from the same region.Results: Several markedly strong relationships between dysgraphia and several measures of cognitive performance in AD patients were observed concomitant with consistent deficits by this patient sample in comparison with the matched group of healthy control subjects were obtained. Additionally, several measures of loss of functional integrity, MMSE, ADL and IADL, were found to be associated with both dysgraphia and impairments in cognitive performance. Conclusion:The present results are discussed from the notion of affected brain regions underlying functions in cognition, language and motor domains that are disturbed in AD.

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“…A positive correlation was observed between the severity of the dementia and spelling/writing measures (lexical and allographic). Agraphia or dysgraphia, observed in early AD [19], encompasses a progressive disorganization and degeneration of the various components of handwriting [20]; these include the complexity of the structure of sentences [21], the diversity and the accuracy of words used [22], punctuation [23], organization [22], the production of grammatically incorrect sentences [24,25], the length of the sentences [24], the amount of written information [25], the morphology of the letters [24] and spelling [26], graphic and spatial layout of letters and their arrangement in texts [15]. Fukui and Lee (2008) [27] examined the possibility that agraphia/dysgraphia may be an early sign of degenerative dementia, reporting the concurrent or subsequent emergence of non-fluent aphasia, ideomotor apraxia, executive dysfunction and asymmetric akinetic-rigid syndrome; these observations implicate degenerative processes involving the parietaloccipital-temporal regions, basal ganglia and striato-frontal projections.…”

Section: Introductionmentioning

confidence: 99%