2021
DOI: 10.1002/micr.30795
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Comparison between normal and reverse orientation of graft in functional and histomorphological outcomes after autologous nerve grafting: An experimental study in the mouse model

Abstract: Background Autologous nerve grafting has been considered the gold standard for the treatment of irreparable nerve gaps. However, the choice of effective proximodistal orientation of autografts (normal or reversed) is controversial. Therefore, we compared functional and histological outcomes between normal and reversed orientations of autografts in a mouse sciatic nerve model. Materials and methods Thirty C57BL/6J mice weighing 20–25 g were assigned to the donor, normally oriented autograft, and reverse‐oriente… Show more

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“…Despite being considered the clinical gold standard for segmental defect reconstruction, the orientation of the donor nerve autograft remains widely debated. The article "Comparison between normal and reverse orientation of graft in functional and histomorphological outcomes after autologous nerve grafting: An experimental study in the mouse model" details an extensive investigation of the effect of autograft orientation on peripheral nerve repair in mice (Lee et al, 2021). Histological and behavioral outcome measures are provided that suggest normal oriented autografts enable greater regeneration and diminished muscle atrophy compared to reverse autografts, and there is no benefit to motor function dependent on autograft orientation.…”
Section: Dear Editormentioning
confidence: 99%
See 1 more Smart Citation
“…Despite being considered the clinical gold standard for segmental defect reconstruction, the orientation of the donor nerve autograft remains widely debated. The article "Comparison between normal and reverse orientation of graft in functional and histomorphological outcomes after autologous nerve grafting: An experimental study in the mouse model" details an extensive investigation of the effect of autograft orientation on peripheral nerve repair in mice (Lee et al, 2021). Histological and behavioral outcome measures are provided that suggest normal oriented autografts enable greater regeneration and diminished muscle atrophy compared to reverse autografts, and there is no benefit to motor function dependent on autograft orientation.…”
Section: Dear Editormentioning
confidence: 99%
“…Lee et al compared the effect of autograft orientation on nerve regeneration in mice by repairing a 3 mm defect was repaired using a 5 mm autograft either in normal or reversed orientation (Lee et al, 2021). Mice are commonly utilized model for high-throughput preclinical testing of novel therapeutics and/or studying mechanism of action(s) following nerve injury.…”
Section: Dear Editormentioning
confidence: 99%