Comparison between N13NH3-PET and 99mTc-Tetrofosmin-CZT SPECT in the evaluation of absolute myocardial blood flow and flow reserve

Giubbini, Raffaele; Bertoli, Mattia; Durmo, Rexhep; Bonacina, Mattia; Peli, Alessia; Faggiano, Ilio; Albano, Domenico; Milan, Elisa; Stern, Eli; Paghera, Barbara; Rodella, Carlo; Cerudelli, Elisabetta; Gazzilli, Maria; Dondi, Francesco; Bertagna, Francesco; Camoni, Luca

doi:10.1007/s12350-019-01939-x

Cited by 65 publications

(43 citation statements)

References 20 publications

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“…For example, several groups have reported methods and success in using singlephoton emission computerized tomography (SPECT)/CT technology for dynamic imaging and MBF quantification. [165][166][167][168][169][170] Additionally, Flurpiridaz (GE Healthcare) is a F18-based tracer which is currently undergoing phase III clinical trials 171 and would provide a commercially available perfusion PET radiotracer, making such imaging accessible to all centers with a PET/CT scanner. It has been used to quantify erythrocyte velocities in the cerebral, renal, intestinal, cardiac, and skeletal muscle microcirculations.…”

Section: F I G U R E 4 Positron Emissionmentioning

confidence: 99%

“…However, there have been recent efforts to overcome these challenges and increase the availability of MBF imaging. For example, several groups have reported methods and success in using single‐photon emission computerized tomography (SPECT)/CT technology for dynamic imaging and MBF quantification 165–170 . Additionally, Flurpiridaz (GE Healthcare) is a F18‐based tracer which is currently undergoing phase III clinical trials 171 and would provide a commercially available perfusion PET radiotracer, making such imaging accessible to all centers with a PET/CT scanner.…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

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Advances in translational imaging of the microcirculation

et al. 2021

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Since Johan Christophorous first described nailfold capillaroscopy in 1663 and Giovanni Rasori and Maurice Raynaud studied capillary changes in inflammation and ischemia in the 18th and 19th centuries, 1 interest in the microcirculation has grown significantly.Advances in imaging technologies over the past several decades have enabled clinicians and researchers to visualize and interrogate the microcirculation directly, or measure parameters, traces or indices that reflect the structural and functional status of the microcirculation. Several of these imaging technologies provide quantitative "readouts" that may directly or indirectly be employed as biomarkers. 2,3 Such noninvasive, imaging biomarkers have the potential to improve clinical assessment of the microcirculation and disease diagnosis, and enable long-term monitoring of treatment response. 4

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Section: F I G U R E 4 Positron Emissionmentioning

confidence: 99%

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

Advances in translational imaging of the microcirculation

et al. 2021

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“…The dynamic imaging capabilities of such cameras enable quantification of absolute MBF using both compartmental modeling, [26][27][28] and a simplified retention model. 29,30 Figure 3C provides an example of SPECT MBF quantification.…”

Section: Spect Blood Flowmentioning

confidence: 99%

Quantitative clinical nuclear cardiology, part 2: Evolving/emerging applications

et al. 2020

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Quantitative analysis has been applied extensively to image processing and interpretation in nuclear cardiology to improve disease diagnosis and risk stratification. This is Part 2 of a two-part continuing medical education article, which will review the potential clinical role for emerging quantitative analysis tools. The article will describe advanced methods for quantifying dyssynchrony, ventricular function and perfusion, and hybrid imaging analysis. This article discusses evolving methods to measure myocardial blood flow with positron emission tomography and single-photon emission computed tomography. Novel quantitative assessments of myocardial viability, microcalcification and in patients with cardiac sarcoidosis and cardiac amyloidosis will also be described. Lastly, we will review the potential role for artificial intelligence to improve image analysis, disease diagnosis, and risk prediction. The potential clinical role for all these novel techniques will be highlighted as well as methods to optimize their implementation. (J Nucl Cardiol 2020)

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“…8 On the other hand, somewhat equivocal results have been found regarding the importance of attenuation correction on MBF quantification with SPECT. 8,10 Fifth, the authors identified a noteworthy difference in hyperemic MBF measured between the modalities. Hyperemic MBF was higher for CZT-SPECT, despite the known lower extraction fraction of sestamibi at higher flow rates than its PET-counterpart, which should, theoretically, result in lower hyperemic MBF values.…”

Section: Introductionmentioning

confidence: 98%

“…Several groups have reported their experience using SPECT for MBF quantification, [4][5][6] including a handful studies that have compared MBF results head-to-head between SPECT and PET in the same population (Table 2). [7][8][9][10][11] In their recent manuscript ''Quantification of myocardial perfusion reserve with CZT-SPECT: comparisons with rubidium PET,'' Acampa et al compare the performance of D-SPECT with rubidium-82 PET. 11 They report that MBF and myocardial flow reserve (MFR) measured by CZT-SPECT correlate moderately well compared to PET (Pearson correlation * 0.5) in 25 patients referred for clinical evaluation.…”

Section: Introductionmentioning

confidence: 99%