Comparison Between Multivolume CT-Based Surrogates of Regional Ventilation in Healthy Subjects

Pennati, Francesca; Salito, Caterina; Baroni, Guido; Woods, Jason C.; Aliverti, Andréa

doi:10.1016/j.acra.2014.05.022

Cited by 17 publications

(20 citation statements)

References 29 publications

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“…With motion navigators derived from the radial trajectory, it is potentially feasible to retrospectively reconstruct images not only to reduce bulk motion, but at multiple lung inflation volumes throughout the respiratory cycle . This could allow quantification of tidal lung volumes and regional changes in parenchymal density as a function of lung volume, potentially providing local compliance measures relative to ventilation …”

Section: Discussionmentioning

confidence: 99%

“…16,18,19 This could allow quantification of tidal lung volumes and regional changes in parenchymal density as a function of lung volume, potentially providing local compliance measures relative to ventilation. 27,28 Overall, our goal was to reduce the risks of longitudinal assessment of neonatal pulmonary disease via nonionizing pulmonary MRI methods that are motion-insensitive and do not require sedation. As more hospitals install MRI scanners sited within their NICUs, the translational feasibility of neonatal MRI will increase.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system

Hahn

Higano

Walkup

et al. 2016

J. Magn. Reson. Imaging

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Purpose To determine feasibility of pulmonary MRI of neonatal lung structures enabled by combining two novel technologies: first, a 3D radial ultrashort echo time (UTE) pulse sequence capable of high spatial resolution full-chest imaging in non-sedated quiet-breathing neonates, and second, a unique, small-footprint 1.5T MRI scanner design adapted for neonatal imaging and installed within the Neonatal Intensive Care Unit (NICU). Materials and Methods Ten patients underwent MRI within the NICU, in accordance with an approved Institutional Review Board protocol. Five had clinical diagnoses of bronchopulmonary dysplasia (BPD), and five had putatively normal lung function. Pulmonary imaging was performed at 1.5T using 3D radial UTE and standard 3D fast gradient recalled echo (FGRE). Diagnostic quality, presence of motion artifacts, and apparent severity of lung pathology were evaluated by two radiologists. Quantitative metrics were additionally used to evaluate lung parenchymal signal. Results UTE images showed significantly higher signal in lung parenchyma (p <0.0001) and fewer apparent motion artifacts compared to FGRE (p = 0.046). Pulmonary pathology was more severe in patients diagnosed with BPD relative to controls (p = 0.001). Infants diagnosed with BPD also had significantly higher signal in lung parenchyma, measured using UTE, relative to controls (p = 0.002). Conclusion These results demonstrate the technical feasibility of pulmonary MRI in free-breathing, non-sedated infants in the NICU at high, isotropic resolutions approaching that achievable with CT. There is potential for pulmonary MRI to play a role in improving how clinicians understand and manage care of neonatal and pediatric pulmonary diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system

Hahn

Higano

Walkup

et al. 2016

J. Magn. Reson. Imaging

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“…Different image registration algorithms and parameter settings can significantly alter CT ventilation values [83 85] and alternatives to image registration have been explored [79,86]. 4D-CT artefacts [83,87], CT noise [88], gravity [89,90], and breathing manoeuvre [91 93] may also have an impact on CTbased measures, and reproducibility is moderate [92,94].…”

Section: 3mentioning

confidence: 99%

“…The majority of SPECT-guided treatment planning has used pulmonary perfusion. MRIguided planning has so far been conducted with ventilation but MR measures of perfusion are also possible [22], while CT-based metrics offer surrogate measures of regional lung ventilation [90]. For a complete representation of regional lung function, both perfusion and ventilation data are required and thus there may be benefit in analysing both defects together for functional-image guided treatment planning [121].…”

Section: Perfusion Ventilationmentioning

confidence: 99%

Functional Image-guided Radiotherapy Planning for Normal Lung Avoidance

et al. 2016

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ReuseThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can't change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/ Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. 1 AbstractFor patients with lung cancer undergoing curative intent radiotherapy, functional lung imaging can be incorporated into treatment planning to modify the dose distribution within non-target volume lung by differentiation of lung regions that are functionally defective or viable. This concept of functional image-guided lung avoidance treatment planning has been investigated with several imaging modalities, primarily SPECT but also hyperpolarised gas MRI, PET and CT-based measures of lung biomechanics. Here, we review the application of each of these modalities, review practical issues of lung avoidance implementation, including image registration and the role of both ventilation and perfusion imaging, and provide guidelines for reporting of future lung avoidance planning studies.

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“…In patients with emphysema, maps of change-specific gas volume were heterogeneous, identifying regions of trapped gas and emphysema, compared with healthy controls. 22,23 Although multivolume CT is unexplored in BPD survivors, in the future, it could be refined and implemented to quantify alveolar simplification in BPD, and in the rare instances of acquired lobar emphysema, could aid in planning volume reduction surgery. 24 In addition, alveolar simplification and air trapping potentially could be quantified using densitometric histograms in ways similar to emphysema; however, an absolute threshold will likely be inappropriate as lung density decreases as children grow and age.…”

Section: Computerized Tomographymentioning

confidence: 99%