Comparison between MRI with MR cholangiopancreatography and endoscopic ultrasonography for differentiating malignant from benign mucinous neoplasms of the pancreas

Hwang, Jiyoung; Kim, Young Kon; Min, Ji Hye; Jeong, Woojin; Hong, Seong Sook; Kim, Hyun‐Joo

doi:10.1007/s00330-017-4926-5

Cited by 30 publications

(24 citation statements)

References 30 publications

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“…We have directly characterized human pancreatic tissue in a manner that can also be applied to engineered scaffolds for translational applications. Our characterization method has enabled us to confirm qualitative and quantitative findings that pancreatic tumors are stiffer than normal pancreas [3,52,53], but importantly, our system enables direct comparison to in vitro constructs that previous methods did not. Our values for elastic modulus of patient tissue were similar to direct mechanical characterization by mesoscale indentation (normal = 0.787 – 1.452 kPa and tumor = 1.885 – 13.70 kPa), and relative values for elastography showed similar trends.…”

Section: Discussionmentioning

confidence: 85%

Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties

et al. 2018

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Understanding tumor-stroma crosstalk in pancreatic ductal adenocarcinoma (PDAC) is challenged by a lack of stroma-mimicking model systems. To design appropriate models, pancreatic tissue must be characterized with a method capable of evaluating in vitro models as well. Our indentation-based characterization tool quantified the distinct viscoelastic signatures of inflamed resections from pancreatitis, tumors from PDAC, and otherwise normal tissue to inform development of mechanically appropriate engineered tissues and scaffolds. We also made progress toward a 3D in vitro system that recapitulates mechanical properties of tumors. Our in vitro model of stromal cells in collagen and complementary characterization system can be used to investigate mechanisms of cancer-stroma crosstalk in PDAC and to propose and test innovative therapies.

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Section: Discussionmentioning

confidence: 85%

Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties

et al. 2018

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“…A combination of T2-HASTE and DWI has been shown to have similar accuracy to a comprehensive contrast-enhanced MRI protocol for the detection of pancreatic cancer. 43 A recent study suggested that MRI with MRCP has a better diagnostic performance than endoscopic ultrasound (EUS) for differentiating malignant from benign pancreatic IPMN and MCN, 44 but conclusive evidence is lacking.…”

Section: Recommendationsmentioning

confidence: 99%

European evidence-based guidelines on pancreatic cystic neoplasms

2018

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Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring <40 mm without an enhancing nodule. Relative indications for surgery in IPMN include a main pancreatic duct (MPD) diameter between 5 and 9.9 mm or a cyst diameter ≥40 mm. Absolute indications for surgery in IPMN, due to the high-risk of malignant transformation, include jaundice, an enhancing mural nodule >5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.

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“…Two recent studies have showed different results comparing both techniques. In one of them, MRI-MRCP was considered more sensitive for differentiating malignant from benign IPMN and mucinous cystic neoplasms (MCN) [12]. In the other study was also included contrast-enhanced CT, but significant difference was not observed [13] Larger series that compare EUS and MRI-MRCP in the surveillance population are therefore required.…”

Section: Introductionmentioning

confidence: 99%

Agreement among Magnetic Resonance Imaging/Magnetic Resonance Cholangiopancreatography (MRI-MRCP) and Endoscopic Ultrasound (EUS) in the evaluation of morphological features of Branch Duct Intraductal Papillary Mucinous Neoplasm (BD-IPMN)

et al. 2018

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Comparison between MRI with MR cholangiopancreatography and endoscopic ultrasonography for differentiating malignant from benign mucinous neoplasms of the pancreas

Abstract: • The A values of MRI were higher than those of EUS. • The diagnostic accuracies of MRI were higher than those of EUS. • The specificities of MRI were higher than those of EUS.

Cited by 30 publications

References 30 publications

Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties

Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties

European evidence-based guidelines on pancreatic cystic neoplasms

Agreement among Magnetic Resonance Imaging/Magnetic Resonance Cholangiopancreatography (MRI-MRCP) and Endoscopic Ultrasound (EUS) in the evaluation of morphological features of Branch Duct Intraductal Papillary Mucinous Neoplasm (BD-IPMN)

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