Comparison between methyldopa and combination of methyldopa and nifedipine in terms of mean change in blood pressure in pregnancy induced hypertension

Abstract

Objective: Comparison between Methyldopa and combination of Methyldopa and Nifedipine in terms of mean change in blood pressure in pregnancy induced hypertension. Material and methods: This randomized controlled trial was conducted at Department of Obstetrics and Gynecology, Combined Military Hospital Bahawalpur from February 2020 to August 2020 over the period of 6 months. Total 80 patients with pregnancy induced hypertension as per operational definition having age 20-40 years and having gestational age ≥ 20 weeks assessed on LMP were selected. Results: Mean age of the patients was 30.81 ± 5.670 years, mean age of patients of group A was 31.50 ± 5.809 years and mean age of group B was 30.13 ± 5.515 years. Mean gestational age was 30.17 ± 5.981 weeks, mean gestational age of patients of group A was 29.70 ± 6.329 weeks and mean gestational age of patients of group B was 30.65 ± 5.65 weeks. In group A, mean diastolic blood pressure was decrease from 101.2250 ± 4.97938 to 84.5000 ± 3.26599 and in group B from 107.7750 ± 7.18434 to 82.5000 ± 2.25320. Comparison of mean decrease in diastolic blood pressure between group A (High dose Methyldopa) and group B (Low dose Low dose Methyldopa with Nifedipine) was done. Mean decrease in diastolic blood pressure in group A was 16.72 ± 3.935 and in group B was 25.28 ± 6.876. Statistically significant difference of mean decrease in diastolic blood pressure between the both groups was noted with p value 0.000. Conclusion: Results of this study showed that Low dose Methyldopa with Nifedipine combination is more effective as compared to High dose Methyldopa to reduce diastolic blood pressure in pregnant women suffering from pregnancy induced hypertension. Keywords: Diastolic blood pressure, Methyldopa, Nifedipine, Pregnancy induced hypertension, Systolic blood pressure

Hubungan Penggunaan Kombinasi Antihipertensi Dengan Luaran Neonatal pada Pasien Preeklamsia

“…Terdapat dua jenis terapi kombinasi yang digunakan yaitu kombinasi antara amlodipin dengan metildopa dan nifedipin dengan metildopadimana kombinasi kedua obat ini paling banyak digunakan (28,4%). Sebuah hasil studi menunjukkan terapi kombinasi nifedipin dan metildopa menghasilkan penurunan tekanan darah diastolik yang lebih baik dibandingkan te rapi tunggal dengan metildopa dosis tinggi [26]. Meskipun demikian, pasien dengan terapi kombinasi antihipertensi biasanya merupakan pasien dengan gangguan hipertensi berat yang tidak terkontrol, sehingga cenderung menghasilkan luaran persalinan yang merugikan.…”