Comparison between male and female breast cancer survival using propensity score matching analysis

Scomersi, Serena; Giudici, Fabiola; Cacciatore, Giuseppe; Losurdo, Pasquale; Fracon, Stefano; Cortinovis, Sara; Ceccherini, Rita; Zanconati, Fabrizio; Tonutti, M.; Bortul, Marina

doi:10.1038/s41598-021-91131-4

Cited by 12 publications

(13 citation statements)

References 28 publications

(38 reference statements)

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“…Male breast cancer is rare and is often diagnosed at an older age and later stage than female breast cancer, possibly influencing our results. 22 Previous studies are in line with our data and found small, if any, sex differences in association between VTE and cancer. A large registry-based study of patients with cancer reported higher multivariable adjusted risk of hospital-associated VTE in women (4.3%) compared with men (4.0%), giving an OR of 1.14 (95% CI 1.12-1.16).…”

Section: Discussionsupporting

confidence: 93%

Prevalence of Cancer in Patients with Venous Thromboembolism: A Retrospective Nationwide Case-Control Study in Sweden

Sandblad

Hansson

Philipson

et al. 2023

Clin Appl Thromb Hemost

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Cancer is a risk factor for venous thromboembolism (VTE). We aimed to define sex-specific risk of preceding cancer in patients with a first-time VTE by conducting a nationwide Swedish registry-based study including 298 172 patients with VTE and 1 185 079 matched controls. This included 44 685 patients with a diagnosis of cancer at/or within 1 year before a VTE diagnosis. Female patients with VTE had a higher multivariable adjusted odds ratios of preceding cancer than male patients with VTE (5.5 [99% confidence interval 5.4-5.7] vs 3.9 [3.8-4.0]). The highest risk of cancer in patients with VTE were found for pancreatic cancer (women: 19.6 [15.8-24.4]; men: 17.2 [13.7-21.6]) and brain cancer (women: 17.4 [12.9-23.4]; men: 17.5 [13.8-22.2]). Weak associations were seen between VTE and bladder/urothelial cancer (women: 1.31 [1.12-1.53]; men: 1.34 [1.23-1.47]), prostate cancer (men: 2.17 [2.07-2.27]), malignant melanoma (women: 2.51 [2.07-3.05]; men: 2.67 [2.23-3.18]), and kidney cancer (women: 3.20 [2.49-4.11]; men: 3.33 [2.79-4.07]). In conclusion, associations with VTE were weak for bladder/urothelial cancer and kidney cancer, and strong for pancreatic, brain, and biliary cancers.

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Section: Discussionsupporting

confidence: 93%

Prevalence of Cancer in Patients with Venous Thromboembolism: A Retrospective Nationwide Case-Control Study in Sweden

Sandblad

Hansson

Philipson

et al. 2023

Clin Appl Thromb Hemost

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“…The rate of diagnosis of stage III and de novo stage IV disease was similar between men and women. In addition, stage-based OS for this cohort was similar to those found in the literature for male breast cancer, with stage IV having the worst clinical outcomes and ductal carcinoma in situ (DCIS) having the best [ 22 , 23 ].…”

Section: Discussionsupporting

confidence: 68%

“…Both older age and stage IV disease have been shown to decrease survival in male breast cancer populations [ 22 , 24 , 25 , 26 ]. Likewise, similar to females, lymph node-positive disease has been reported to be associated with inferior outcomes [ 23 , 25 ]. Poor performance status is known to be an important prognostic factor and, especially in advanced-stage disease, has been associated with inferior outcomes [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Rural Men with Breast Cancer: A Multicenter Population Based Retrospective Cohort Study

Fisher

Ahmed

Chalchal

et al. 2023

Cancers

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Background: Breast cancer is rare in men. This population-based study aimed to determine outcomes of male breast cancer in relation to residence and other variables. Methods: In this retrospective cohort study, men diagnosed with breast cancer in Saskatchewan during 2000–2019 were evaluated. Cox proportional multivariable regression analyses were performed to determine the correlation between survival and clinicopathological and contextual factors. Results: One hundred-eight eligible patients with a median age of 69 years were identified. Of them, 16% had WHO performance status ≥ 2 and 61% were rural residents. The stage at diagnosis was as follows: stage 0, 7%; I, 31%; II, 42%; III, 11%; IV, 8%. Ninety-eight percent had hormone receptor-positive breast cancer. The median disease-free survival of urban patients was 97 (95% CI: 50–143) vs. 64 (46–82) months of rural patients (p = 0.29). The median OS of urban patients was 127 (94–159) vs. 93 (32–153) months for rural patients (p = 0.27). On multivariable analysis, performance status ≥ 2, hazard ratio (HR) 2.82 (1.14–6.94), lack of adjuvant systemic therapy, HR 2.47 (1.03–5.92), and node-positive disease, HR 2.32 (1.22–4.40) were significantly correlated with inferior disease-free survival in early-stage invasive breast cancer. Whereas stage IV disease, HR 7.8 (3.1–19.5), performance status ≥ 2, HR 3.25 (1.57–6.71), and age ≥ 65 years, HR 2.37 (1.13–5.0) were correlated with inferior overall survival in all stages. Conclusions: Although residence was not significantly correlated with outcomes, rural men had numerically inferior survival. Poor performance status, node-positive disease, and lack of adjuvant systemic therapy were correlated with inferior disease-free survival.

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“…Every patient signed an informed consent for data unspecified use and the local ethical committee approved the anonymously data use, according to our legislation (GDPR 679/2016, Par.26) [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

Survival and long-term surgical outcomes after colorectal surgery: are there any gender-related differences?

et al. 2022

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Colorectal cancer (CRC) incidence and mortality seems to be lower in women than in men. The present study aims to evaluate the impact of gender on CRC diagnosis, treatment, and survival. This is a retrospective cohort study based on a single-center dataset of CRC patients from the University Hospital of Trieste (Italy). Data of 1796 consecutive CRC patients referred to our center from November 11th, 2004, to December 31st, 2017, were analyzed. Right-sided carcinomas are more frequent in women than in men; furthermore, women had a lower surgical complication rate. Men showed a higher 5- and 10-year mortality. This survival benefit for women was observed independently of the tumor localization. The 5-year hazard ratio (HR) for women vs men was 0.776 (p 0.003), and after 10-year 0.816 (p 0.017). Regarding the disease-free survival (DFS), 5 and 10-year HR was 0.759 (p 0.034) and 0.788 (p 0.07), respectively. On multivariable analysis, respecting tumor localization, the odds of female gender were higher than man with right colon disease. Male gender was more independently associated with age at the surgery time. Women survival advantage was higher than men, except for patients older than 80. Surgical outcome and survival after CRC surgical treatment seem to be gender related. For this reason, gender could play an important role in CRC diagnosis and therapy, allowing an earlier diagnosis in women.

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Comparison between male and female breast cancer survival using propensity score matching analysis

Cited by 12 publications

References 28 publications

Prevalence of Cancer in Patients with Venous Thromboembolism: A Retrospective Nationwide Case-Control Study in Sweden

Prevalence of Cancer in Patients with Venous Thromboembolism: A Retrospective Nationwide Case-Control Study in Sweden

Outcomes of Rural Men with Breast Cancer: A Multicenter Population Based Retrospective Cohort Study

Survival and long-term surgical outcomes after colorectal surgery: are there any gender-related differences?

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