Comparison between liver resection and liver transplantation on outcomes in patients with solitary hepatocellular carcinoma meeting UNOS criteria: a population-based study of the SEER database

Yang, Anli; Wang, Ju; Yuan, Xiaopeng; Han, Ming; Wang, Xiaoping; Guo, Zhiyong; Wei, Xiaoli; Wang, Dongping; Zhu, Xiao-feng; Wu, Linwei; He, Xiaoshun

doi:10.18632/oncotarget.22134

Cited by 24 publications

(15 citation statements)

References 34 publications

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“…Hepatocellular carcinoma (HCC) is one of the most commonly occurring cancers and is the second leading cause of cancer-related deaths from malignancy worldwide.1 Despite advances in surgery and chemotherapy, HCC is associated with a poor 5-year survival rate due to its uncontrolled invasion and metastasis under the presently available treatments, including surgery and chemotherapy. Recurrence and metastasis are the major obstacles to improve survival for HCC patients.2 Thus, there is a critical need for improving HCC therapies, which can be developed from the identification of new and effective chemotherapeutic agents and a better understanding of the molecular mechanisms involved.…”

Section: Introductionmentioning

confidence: 99%

<p>Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT</p>

Wei¹,

Lv²,

Xie³

et al. 2019

DDDT

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Background/aims Plumbagin (PL) has been shown to effectively inhibit tumor growth and migration of hepatocellular carcinoma cells in previous studies, but the specific mechanism for this remains unclear. The purpose of this study was to investigate the effects of PL-induced apoptosis in epithelial–mesenchymal transition (EMT) of human hepatocellular carcinoma (HCC) in vivo and in vitro. Methods SMMC-7721 cells were cultured, an EMT model was induced in vitro by TGF-β1, cell proliferation was detected by the MTT assay, cell invasion was analyzed by the Transwell invasion assay, and the apoptosis rate was measured by flow cytometry. RT-PCR was used to detect vimentin, E-cadherin, N-cadherin and snail mRNA, and Western blotting was used to detect the vimentin, caspase-3, PARP-1, E-cadherin, N-cadherin and snail protein expression levels. HE staining and TUNEL staining, immunohistochemistry and immunofluorescence were used to detect the expression levels of bax and bcl-2 in hepatocarcinoma xenografts and to evaluate their apoptosis in vivo. Results The in vitro results showed that PL inhibited the proliferation of EMT model cells, increased the apoptosis rate of the EMT model, and significantly decreased the vimentin, PARP-1, N-cadherin and snail protein levels, but significantly increased E-cadherin and caspase-3 protein expression. In addition, the in vivo results indicated that PL can affect the expression of bax/bcl-2 apoptotic marker proteins. Conclusion PL may induce apoptosis of human hepatocellular carcinoma cells undergoing epithelial–mesenchymal transition by increasing the caspase-3 protein level and cleaving vimentin.

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Section: Introductionmentioning

confidence: 99%

<p>Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT</p>

Wei¹,

Lv²,

Xie³

et al. 2019

DDDT

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“…A total of 18,095 patients with tumours within the Milan criteria were included in our analysis, with 8,204 and 9,891 patients undergoing LT and LR respectively. The majority of articles were retrospective studies (n=34), except for 1 prospective study; 11 articles provided survival data for uninodular HCC (26,(30)(31)(32)34,43,45,46,53,56,60); 2 0 a r t i c l e s h a d a s t u d y e n d -d a t e b e f o r e 2 0 1 0 (33,(35)(36)(37)40,42,43,45,47,(49)(50)(51)(52)(53)(54)(55)(56)(60)(61)(62). Additionally, 14 studies used enhanced surveillance strategies for HCC surveillance after surgery (26,28,30,(33)(34)(35)40,43,44,(56)(57)(58)61,62).…”

Section: Study Selection and Study Characteristicsmentioning

confidence: 99%

Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria: a meta-analysis of 18,421 patients

Koh¹,

Tan²,

Ong³

et al. 2022

Hepatobiliary Surg Nutr

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Background: Outcomes after liver resection (LR) and liver transplantation (LT) for hepatocellular carcinoma (HCC) are heterogenous and may vary by region, over time periods and disease burden. We aimed to compare overall survival (OS) and disease-free survival (DFS) between LT versus LR for HCC within the Milan criteria.Methods: Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan criteria. Meta-analyses and metaregression were conducted using random-effects models.Results: We screened 2,278 studies and included 35 studies with 18,421 patients. LR was associated with poorer OS [hazard ratio (HR) =1.44; 95% confidence interval (CI): 1.14-1.81; P<0.01] and DFS (HR =2.71; 95% CI: 2.23-3.28; P<0.01) compared to LT, with similar findings among intention-to-treat (ITT) studies. In uninodular disease, OS in LR was comparable to LT (P=0.13) but DFS remained poorer (HR =2.95; 95% CI: 2.30-3.79; P<0.01). By region, LR had poorer OS versus LT in North America and Europe (P≤0.01), but not Asia (P=0.25). LR had inferior survival versus LT in studies completed before 2010 (P=0.01), but not after 2010 (P=0.12). Cohorts that underwent enhanced surveillance had comparable OS after LT and LR (P=0.33), but cohorts undergoing usual surveillance had worse OS after LR (HR =1.95; 95% CI: 1.24-3.07; P<0.01).Conclusions: Mortality after LR for HCC is nearly 50% higher compared to LT. Survival between LR and LT were similar in uninodular disease. The risk of recurrence after LR is threefold that of LT.

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“…Vervielfältigung nur mit Zustimmung des Verlages. Die Lebertransplantation für Patienten mit einem auf die Leber begrenzten Tumor ist langfristig mit den geringsten Rezidivraten und dem besten Gesamtüberleben (> 5 Jahre) verbunden [125,126]. Durch Fortschritte in der chirurgischen, interventionellen und medikamentösen Therapie können heute bei resektablen Befunden immer bessere Überlebensraten erreicht werden, allerdings finden sich bei allen anderen Therapieformen auch in frühen Tumorstadien (▶ Tab.…”

Section: Leitlinieunclassified

S3-Leitlinie: Diagnostik und Therapie des hepatozellulären Karzinoms

et al. 2022

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nom-hcc/. Besonderer HinweisDie Medizin unterliegt einem fortwährenden Entwicklungsprozess, sodass alle Angaben, insbesondere zu diagnostischen und therapeutischen Verfahren, immer nur dem Wissensstand zur Zeit der Drucklegung der Leitlinie entsprechen können. Hinsichtlich der angegebenen Empfehlungen zur Therapie und der Auswahl sowie Dosierung von Medikamenten wurde die größtmögliche Sorgfalt beachtet. Gleichwohl werden die Benutzer aufgefordert, die Beipackzettel und Fachinformationen der Hersteller zur Kontrolle heranzuziehen und im Zweifelsfall einen Spezialisten zu konsultieren. Fragliche Unstimmigkeiten sollen bitte im allgemeinen Interesse der OL-Redaktion mitgeteilt werden. Der Benutzer selbst bleibt verantwortlich für jede diagnostische und therapeutische Applikation, Medikation und Dosierung.In dieser Leitlinie sind eingetragene Warenzeichen (geschützte Warennamen) nicht besonders kenntlich gemacht. Es kann also aus dem Fehlen eines entsprechenden Hinweises nicht geschlossen werden, dass es sich um einen freien Warennamen handelt.Das Werk ist in allen seinen Teilen urheberrechtlich geschützt. Jede Verwertung außerhalb der Bestimmung des Urhebergesetzes ist ohne schriftliche Zustimmung der OL-Redaktion unzulässig und strafbar. Kein Teil des Werkes darf in irgendeiner Form ohne schriftliche Genehmigung der OL-Redaktion reproduziert werden. Dies gilt insbesondere für Vervielfältigungen, Übersetzungen, Mikroverfilmungen und die Einspeicherung, Nutzung und Verwertung in elektronischen Systemen, Intranets und dem Internet.In dieser Leitlinie wird aus Gründen der Lesbarkeit die männliche Form verwendet, nichtsdestotrotz beziehen sich die Angaben auf Angehörige aller Geschlechter.

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Comparison between liver resection and liver transplantation on outcomes in patients with solitary hepatocellular carcinoma meeting UNOS criteria: a population-based study of the SEER database

Cited by 24 publications

References 34 publications

<p>Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT</p>

<p>Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT</p>

Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria: a meta-analysis of 18,421 patients

S3-Leitlinie: Diagnostik und Therapie des hepatozellulären Karzinoms

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