Comparison between immunofixation and crossed immunoelectrophoresis for the detection of C3 activation products

Vecchi, A. De; Montagnino, Giuseppe; Massaro, Laura; Constantino, Antonina; Bencini, Pier Luca; Tarantino, A

doi:10.1016/0009-8981(79)90021-4

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…Serum immunoglobulins and complement components (Clq, C4, C3, B, CllN H) were within normal range. No breakdown products of C3 and of factor B were observed after incubation of the patient's serum with normal serum, EDTA, or MgCL EGTA normal plasma [12], thus excluding any anticomplcmentary activity either through the classic or the alternative complement pathway. Plasma lipid and lipoprotein analysis showed; total cholesterol 243 mg/dl (normal 176 ± 27), triglycerides 530 mg/dl (normal 87 ± 37), esterified choles terol 15 mg/dl (normal 128 ± 19), high-density lipoproteins 8 mg/dl (normal 46 ± II), low-density lipoproteins 198 mg/dl (normal 113 ± 27), very low density lipoproteins 37 mg/dl (normal 17 ± 14), LCAT activity undetectable (normal 19.8 ± 8.5 nmol/ml/h).…”

Section: Laboratory Datamentioning

confidence: 99%

Renal Lesions in Familial Lecithin-Cholesterol Acyltransferase Deficiency

et al. 1986

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Renal lesions of a new case of lecithin-cholesterol acyltransferase deficiency in an 18-year-old male are described. Large mesangial deposits and a sieve-like transformation of the peripheral basement membrane were the main glomerular lesions. Immunofluorescence identified C3 deposits in the mesangium. A heterogeneous pattern of ultrastructural findings was observed by electron microscopy. Thread-like structures with faint cross-striation and irregular tubular structures embedded in an amorphous material were found in mesangial and subepithelial sites. Mesangial areas and peripheral basement membranes showed irregular holes sometimes containing highly osmiophilic lamellar bodies. It is suggested that many mechanisms may be involved in the production of renal lesions induced by the lipoprotein abnormalities characteristic of the disease.

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Section: Laboratory Datamentioning

confidence: 99%