Comparison between High-Sensitivity Cardiac Troponin T and Cardiac Troponin I in a Large General Population Cohort

Abstract

BACKGROUND:Few data compare cardiac troponin T (cTnT) and cardiac troponin I (cTnI) in a general population. We sought to evaluate the distribution and association between cTnT, cTnI, and cardiovascular risk factors in a large general population cohort.

Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study

“…25 Recruiting more than 4300 patients is a significant strength of this prospective work, which comprises a 20-fold larger study size compared with preceding work examining the link between troponin and noncardiac morbidity after noncardiac surgery. In contrast to the myocardial infarction literature, where age-related thresholds for troponin appear to be important, 26,27 our data are in keeping with perioperative findings suggesting that even small increments from baseline (preoperative) troponin are prognostically relevant 1 and associated with excess all-cause perioperative morbidity. 2 The study captured several features of contemporary practice, including enhanced recovery based analgesic regimens and fluid therapy, which indicate broadly similar perioperative management and enhanced recovery practices across centres.…”

Measurement of High-Sensitivity Cardiac Troponin in Pulmonary Embolism: Useful Test or a Clinical Distraction

“…61,62 Moreover, there have been publications indicating an age-related increase in hs-cTn concentrations, with debate as to whether these increases are pathological versus physiological. [63][64][65][66] However, in the case of hs-cTnT measurement for risk stratification after PE, a publication has reported improved risk discrimination when utilizing age-adjusted thresholds, 36 with additional studies on hs-cTnT and hs-cTnI needed to fully assess this effect. These additional studies on hs-cTn assessing sex-and agerelated cutoffs might be useful for improving risk stratification and for identifying subsets of patients with acute PE at lower or higher risk of developing unfavorable consequences such as right ventricular dysfunction, CTEPH, impaired cardiac output, progressive end-organ damage, and ultimately death (►Table 2).…”

Carotid Intima-Media Thickness is a Predictor of Subclinical Myocardial Damage in Men with Type 2 Diabetes Mellitus

“…Roche hs-cTnT assay (Roche Diagnostics, Mannheim, Germany) and Abbott hs-cTnI assay (Abbott, Chicago, United States) have been used for several years. Numerous studies focused on diagnostic performance and clinical utility of hs-cTn determination in patients with ACS and in the general population [13][14][15][16][17][18]. Recently, a novel hs-cTnI assay by Siemens (Siemens Healthineers, Eschborn, Germany), following referred to as ADVIA Centaur hs-cTnI, has become available.…”

“…Methods In this cross-sectional study we analyzed clinical and laboratory parameters of 234 patients (43 % women) with T2DM and a median age of 65 years (interquartile range: 57-71). The median duration of diabetes mellitus was 10 years (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Anthropometric data, blood pressure, glycemic parameters and lipid profiles were determined.…”