Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study

Hino, Hideki; Matsuura, Tadashi; Kihara, Yuki; Tsujikawa, Shogo; Mori, Takashi; Nishikawa, Kiyonobu

doi:10.1007/s00540-019-02657-x

Cited by 18 publications

(16 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This present study TIVA group (P) compared to Inhalational group(S) showed; significantly decreased systemic hemodynamics (HR, MAP, and PETCO2) which can be attributed to one of two or both explanation; The 1 st is the negative inotropic& chronotropic effects of Propofol itself. In line with our result explanation, Hino etal.,2019 [21] who advised superiority of Thiopental over Propofol for avoiding hypotension during GA induction. Contrary to our hemodynamic results, Lauta E etal 2010 [22] reported no significant hemodynamic differences with either propofol or sevoflurane.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Oxygenation and Metabolism in Patients Undergoing Clipping of Cerebral Aneurysm: A Comparative Study between Propofol-based total intravenous anesthesia and Sevoflurane-based inhalational anesthesia.

Ghanem

Elemam

Mousa

et al. 2021

Egyptian Journal of Anaesthesia

View full text Add to dashboard Cite

Background: Sevoflurane unfortunately increases the cranial blood flow, blood volume, and pressure changes cope with cerebral aneurysmal neuroanesthesia goals. Propofol decreases the brain metabolism, blood flow, preserve cerebral reactivity to carbon dioxide, creates neuroprotective effect during cerebral ischemia. Hypothesis: Propofol-based total intravenous anesthesia would be more appropriate than sevoflurane-based inhalational technique during surgical clipping of cerebral aneurysm. Methods: A prospective, randomized, comparative study on 50 patients subjected for elective clipping of cerebral aneurysm, randomly allocated into two equal groups of 25 patients each: propofol-dormicum total intravenous only group and sevoflurane based inhalational group. Results: Jugular oxygen saturation (primary outcome), cerebral blood flow equivalent, heart rate, mean arterial blood pressure, and end tidal carbon dioxide tension were statistically significantly decreased in propofol group compared to sevoflurane group at basal, just after dura opening, at 1,2,3 hours later, and after scalp closure. Arterio-Jugular oxygen content difference, cerebral extraction ratio of O 2 , estimated cerebral metabolic rate for O 2 , serum lactate (mg/dl) showed significant increase in propofol group compared to sevoflurane group at basal, 1, 2, 3 h, and after scalp closure. Duration of surgery, time of recovery, blood loss, blood transfusion, intraoperative complications, urine output, total midazolam consumption, surgeon satisfaction, intensive care unit stay time, and Ramsay sedation scale difference was not significant in between both studied groups during the early postoperative period. Conclusion: Propofol based total intravenous anesthesia has better cerebral oxygenation and neuro anesthesia profile compared to sevoflurane-based inhalational anesthesia during cerebral aneurysm clipping surgery with systemic hemodynamic stability.

show abstract

Section: Discussionmentioning

confidence: 99%

Cerebral Oxygenation and Metabolism in Patients Undergoing Clipping of Cerebral Aneurysm: A Comparative Study between Propofol-based total intravenous anesthesia and Sevoflurane-based inhalational anesthesia.

Ghanem

Elemam

Mousa

et al. 2021

Egyptian Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…It can inhibit cell death by reducing the expression of tumor necrosis factor alpha (TNF-α) and TNFR1 proteins, which is conducive to perioperative cerebral protection without affecting cerebrovascular hemodynamics. 17,18 Sufentanil has a strong affinity for opioid receptors, resulting in a more vigorous analgesic intensity and a longer duration of action than remifentanil. However, the metabolism of sufentanil is mainly dependent on liver blood flow.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of analgesic and sedative effects of remifentanil‐based fast‐track anesthesia in children undergoing transthoracic device closure of ventricular septal defects

Kim

Huang

et al. 2021

J Card Surg

View full text Add to dashboard Cite

Background: This study aimed to evaluate the analgesic and sedative effects of remifentanil-based fast-track cardiac anesthesia in children undergoing transthoracic device closure of ventricular septal defects (VSDs). Methods: A retrospective analysis was conducted on 62 children who underwent transthoracic device closure of VSDs from May 2019 to August 2019. The patients were divided into two groups based on the anesthesia methods: group F was given remifentanil-based fast-track cardiac anesthesia, and Group C was given conventional anesthesia. Patient-related clinical data, postoperative analgesia scores, and sedation scores were collected and analyzed. Results: There was no significant difference in intraoperative hemodynamic changes, bispectral index values, postoperative analgesia scores, sedation scores, or the incidence of adverse events between the two groups. Compared with Group C, the duration of mechanical ventilation and the length of intensive care unit (ICU) and hospital stay in group F were significantly lower. Conclusion: Remifentanil-based fast-track anesthesia can be safely applied in children undergoing transthoracic device closure of VSDs, with acceptable postoperative analgesia and sedation effects and shorter mechanical ventilation times and ICU and hospital stays compared with conventional anesthesia. K E Y W O R D S analgesic, fast-track anesthesia, remifentanil, sedative, VSD 1 | BACKGROUND A ventricular septal defect (VSD) is one of the most common cardiac malformations, accounting for 40% of all cardiac malformations. 1 Surgical repair and percutaneous device closure of VSDs are the two most commonly used methods in clinical practice. 2 In recent years, transthoracic device closure of VSDs without extracorporeal circulation, which is another possible treatment, has been widely used and reported in China. Transthoracic device closure of VSDs has the advantages of a small incision, rapid recovery, fewer complications,

show abstract

“…Hypotension is frequently observed as a side effect during induction of anesthesia using propofol [20][21][22]. A phase I clinical trial for remimazolam revealed that a 1-min bolus infusion of remimazolam 0.01-0.30 mg/kg did not cause hypotension, which was defined as systolic blood pressure lower than 80 mmHg, except one occurrence of hypotension 8 h after the dose of remimazolam [2].…”

Section: Hypotension: Side Effect Of Induction Agentmentioning

confidence: 99%

Remimazolam besilate, a benzodiazepine, has been approved for general anesthesia!!

Masui

2020

J Anesth

View full text Add to dashboard Cite

Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study

Cited by 18 publications

References 23 publications

Cerebral Oxygenation and Metabolism in Patients Undergoing Clipping of Cerebral Aneurysm: A Comparative Study between Propofol-based total intravenous anesthesia and Sevoflurane-based inhalational anesthesia.

Cerebral Oxygenation and Metabolism in Patients Undergoing Clipping of Cerebral Aneurysm: A Comparative Study between Propofol-based total intravenous anesthesia and Sevoflurane-based inhalational anesthesia.

Evaluation of analgesic and sedative effects of remifentanil‐based fast‐track anesthesia in children undergoing transthoracic device closure of ventricular septal defects

Remimazolam besilate, a benzodiazepine, has been approved for general anesthesia!!

Contact Info

Product

Resources

About