Comparison between gold nanoparticles synthesized by radiolysis and by EGCG-driven gold reduction

Freitas, Lucas Freitas de; Cruz, Cassia P. C.; Cavalcante, A.K.; Batista, Jorge Gabriel dos Santos; Varca, Gustavo H.C.; Mathor, Mônica Beatriz; Lugão, Ademar B.

doi:10.1016/j.radphyschem.2020.108959

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…Gold appears purple, not golden, from a particle size of 100 nm or less, and gradually changes color from purple to red when the size is further reduced. In this study, it was confirmed that gold nanoparticles were synthesized as the color change of the reaction solution occurred, gold nanoparticles prepared by de Freitas et al, [69] as a reducing agent using green tea leaf extract. Wavelength range measured by UV-vis spectroscopy for UV formation monitoring nanoparticles showing a sharp 520 nm peak.…”

Section: Gold Nanoparticles (Au -Nps)supporting

confidence: 66%

Tea Plant Leaves for Green Synthesis of Metallic Nanoparticles

Ismael

Ahmed

Ibrahim

et al. 2023

Macromolecular Symposia

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Synthesis of metallic nanoparticles using tea plant leaves is a well-recognized and non-toxic method. During the last few decades, synthesis of metal nanoparticles using plant extract is useful not only because of its reduced environmental but also because it can be used to produce large quantities of nanoparticles. Plant extracts may act both as reducing agents and stabilizing agents in the synthesis of nanoparticles, this has motivated the researchers to synthesis the nanoparticles using this route that allows better control of shape and size for various applications. This paper reviews the methods of synthesizing by using metals (e.g., gold [Au], silver [Ag], Iron [Fe], Cadmium [Cd], Palladium [Pd], copper [Cu]), nanoparticles from tea plant leaves extracts as well as their characteristics and some applications. The aim of this review is to report the effect of tea extraction for synthesis metallic nanoparticles (NPs) and compare the nanoscale properties and its applications.

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Section: Gold Nanoparticles (Au -Nps)supporting

confidence: 66%

Tea Plant Leaves for Green Synthesis of Metallic Nanoparticles

Ismael

Ahmed

Ibrahim

et al. 2023

Macromolecular Symposia

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“…The reason why the AuNPs were stable in DI water is likely the absence of inorganic salts. It is known that the green-synthesized EGCG-AuNPs are stable in 0.11–14.4% NaCl solution . Therefore, NaCl in D-PBS, DMEM, and RMPI-1640 should not be the direct trigger to induce the aggregation of the EGCG-AuNPs.…”

Section: Resultsmentioning

confidence: 99%

“…It is known that the green-synthesized EGCG-AuNPs are stable in 0.11−14.4% NaCl solution. 22 Therefore, NaCl in D-PBS, DMEM, and RMPI-1640 should not be the direct trigger to induce the aggregation of the EGCG-AuNPs. However, Xu et al reported that citrate-AuNPs are aggregated in 50 mM NaCl aqueous solution.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…used EGCG-AuNPs as nanocarriers to deliver doxorubicin, Yuan et al designed fucose-grafted EGCG-AuNP composites, and Shukla et al synthesized radioactive 198 AuNP–EGCG for the effective treatment of prostate cancer with minimal damage to critical tissues as radiotherapy . Although AuNPs have been studied as radiosensitizers, − which can enhance the radiosensitization of tumor tissues, EGCG-AuNPs as radiosensitizers have not been reported so far, as far as we know. Furthermore, the effect of the size and shape of EGCG-AuNPs on stability in physiological environments, cytotoxicity, and cellular uptake remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Size Dependency of Selective Cellular Uptake of Epigallocatechin Gallate-modified Gold Nanoparticles for Effective Radiosensitization

Gan

Wakayama

Inubushi

et al. 2021

ACS Appl. Bio Mater.

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The high incidence and mortality of cancer make it a global health issue. However, conventional cancer therapies have several disadvantages, especially serious side effects due to low selective toxicity to cancer cells. Gold nanoparticles (AuNPs) are an excellent drug carrier, enhance drug delivery efficiency, and hold promise for photothermal and radiation therapies. (−)-Epigallocatechin-3-gallate (EGCG) is the major polyphenolic antioxidant constituent of green tea, has a potent antitumor effect, and binds specifically to the 67 kDa laminin receptor, which is overexpressed on the surface of several cancer cell lines such as HeLa and MDA-MB-231 cells. We synthesized EGCG-modified AuNPs (EGCG-AuNPs) using ratios (n EGCG/n gold) from 1:2 to 10:1 and evaluated their size, morphology, stability, antioxidant ability, cytotoxicity, cellular uptake, and uptake mechanisms in vitro in comparison with the conventional AuNPs prepared by using citrate as the reducing agent (citrate-AuNPs). In HeLa cells, EGCG-AuNPs (10:1) (135 nm diameter, sea-urchin-like shape) exhibited the highest cellular uptake. Conversely, EGCG-AuNPs (1:2) (39 nm diameter, spherical shape) were preferentially taken up by MDA-MB-231 cells. Cellular uptake of EGCG-AuNPs toward normal cells (NIH3T3 cells) was found to be in a nonspecific manner, and the amount of uptake was suppressed. X-ray irradiation after cellular uptake of EGCG-AuNPs (1:2) in MDA-MB-231 cells significantly enhanced irradiation-induced cell death. These findings suggest enhanced cellular uptake of EGCG-AuNPs with a 39 nm diameter and their potential use in combinatorial therapeutics of EGCG-AuNPs for breast cancer.

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