Comparison between frail and non-frail older adults’ gut microbiota: A systematic review and meta-analysis

Almeida, Helena Maia; Sardeli, Amanda Veiga; Conway, Jessica M.; Duggal, Niharika Arora; Cavaglieri, Cláudia Regina

doi:10.1016/j.arr.2022.101773

Cited by 15 publications

(10 citation statements)

References 84 publications

(119 reference statements)

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“…in the gut microbiota [ 158 ]. Conversely, as discussed in Section 3.1 , Lactobacillus is considered as one of the most promising probiotics against sarcopenia with its supplementation being associated with improvements in muscle mass and physical function in both mouse models and human beings [ 68 , 159 , 160 ]. In particular, the administration of Lactobacillus paracasei , leucine and omega-3 fatty acids was particularly effective in improving muscle mass and function in a group of older frail individuals with an average age of 79.7 years old [ 161 ].…”

Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

et al. 2023

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Sarcopenia, the age-related loss of muscle mass and function increasing the risk of disability and adverse outcomes in older people, is substantially influenced by dietary habits. Several studies from animal models of aging and muscle wasting indicate that the intake of specific polyphenol compounds can be associated with myoprotective effects, and improvements in muscle strength and performance. Such findings have also been confirmed in a smaller number of human studies. However, in the gut lumen, dietary polyphenols undergo extensive biotransformation by gut microbiota into a wide range of bioactive compounds, which substantially contribute to bioactivity on skeletal muscle. Thus, the beneficial effects of polyphenols may consistently vary across individuals, depending on the composition and metabolic functionality of gut bacterial communities. The understanding of such variability has recently been improved. For example, resveratrol and urolithin interaction with the microbiota can produce different biological effects according to the microbiota metabotype. In older individuals, the gut microbiota is frequently characterized by dysbiosis, overrepresentation of opportunistic pathogens, and increased inter-individual variability, which may contribute to increasing the variability of biological actions of phenolic compounds at the skeletal muscle level. These interactions should be taken into great consideration for designing effective nutritional strategies to counteract sarcopenia.

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Section: Interaction Between Phenolic Compounds and Microbiota: Possi...mentioning

confidence: 99%

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

et al. 2023

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“… Clinical Frailty Scale Shotgun Bacteroides dorei , Flavonifractor plautii ↑ Bacteroides vulgatus , Anaerostipes hadrus , Faecalibacterium prausnitzii ↓ Haran, 2021 30 US Skilled nursing facility dwellers (SNFD) (22, 65–97) Community dwellers (CD) (25, 65–91) Young adult (YA) (95, 18–55) Rockwood’s Frailty Index Fried’s Frailty Phenotype Physical Activity Scale for the Elderly Shotgun Clostridium species ↑ in SNFD no Prevotella -rich enterotype in SNFD Larson, 2022 31 Multiple (meta-analysis) Community dwellers, nursing homes, hospitalized (340, 63–83) Fried’s Frailty Phenotype Clinical Frailty Scale Groningen Frailty Indicator etc. Shotgun, 16S Eggerthella lenta , Eubacterium cylindroides , Eubacterium dolichum ↑ Alistipes shahii , Faecalibacterium prausnitzii , Roseburia inulinivorans ↓ Almeida, 2022 32 …”

Section: The Gut Microbiome and Frailtymentioning

confidence: 99%

“…A recent meta-analysis of previous studies on gut microbiome composition in frail and non-frail older adults, including community dwellers, hospitalized individuals/nursing home residents, and chronic kidney patients, showed a lower relative abundance of F. prausnitzii , Alistipes shahii , and Roseburia inulinivorans species and a higher relative abundance of E. lenta , Eubacterium cylindroides , and E. dolichum in frail older adults than in non-frail older adults. 32 …”

Section: The Gut Microbiome and Frailtymentioning

confidence: 99%

Gut microbiome in healthy aging versus those associated with frailty

Lim,

Nam

2023

Gut Microbes

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As the proportion of older people in the world’s population steadily increases, there is an urgent need to identify ways to support healthy aging. The gut microbiome has been proposed to be involved in aging-related diseases and has become an attractive target for improving health in older people. Herein, we cover the relationship between the gut microbiome and chronological age in adults, and then, we discuss the gut microbiome features associated with frailty, as a hallmark of unhealthy aging in older people. Furthermore, we describe the effects of microbiome-targeted interventions, such as dietary patterns and consumption of probiotics, prebiotics, and synbiotics, on modulating the gut microbiome composition and further promoting healthy aging. Further studies are needed to explore the underlying mechanisms of gut microbiome-induced aging complications and to develop personalized microbiome-based strategies for reducing the severity of frailty or preventing the onset of frailty in older adults.

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“…In the later stages of life, elderly people experience another shift in their gut microbiota composition, which is characterized by a decrease in bacterial richness, particularly in beneficial species such as Bifidobacterium , Akkermansia , and members of Clostridium Clusters IV ( 31 , 32 ). These changes may affect immune function, nutrient absorption, and susceptibility to age-related conditions, such as frailty and chronic diseases ( 31 , 33 , 34 ).…”

Section: Introductionmentioning

confidence: 99%

Taxonomic and metabolic development of the human gut microbiome across life stages: a worldwide metagenomic investigation

Mancabelli,

Milani,

De Biase

et al. 2024

mSystems

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The human gut microbiota is a dynamic community of microorganisms that undergo variable changes over the entire life span. To thoroughly investigate the possible fluctuations of the microbiota throughout human life, we performed a pooled analysis of healthy fecal samples across different age groups covering the entire human life span. Our study integrated data from 79 publicly available studies and new stool samples from an Italian cohort, i.e., the Parma Microbiota project, resulting in 6,653 samples processed through the shotgun metagenomic approach. This approach has allowed species-level taxonomic reconstruction of the gut microbiota and investigation of its metabolic potential across the human life span. From a taxonomic point of view, our findings confirmed and detailed at species-level accuracy that the microbial richness of the gut microbiota gradually increases in the first stage of life, becoming relatively stable during adolescence. Moreover, the analysis identified the potential core microbiota representative of distinct age groups, revealing age-related bacterial patterns and the continuous rearrangement of the microbiota in terms of relative abundances across the life span rather than the acquisition and loss of taxa. Furthermore, the shotgun approach provided insights into the functional contribution of the human gut microbiome. The metagenomic analysis revealed functional age-related differences, particularly in carbohydrate and fiber metabolism, suggesting a co-evolution of the microbiome assembly with diet. Additionally, we identified correlations between vitamin synthesis, such as thiamine and niacin, and early life, suggesting a potential role of the microbiome in human physiology, in particular in the functions of the host’s nervous and immune systems. IMPORTANCE In this study, we provided comprehensive insights into the dynamic nature of the human gut microbiota across the human life span. In detail, we analyzed a large data set based on a shotgun metagenomic approach, combining public data sets and new samples from the Parma Microbiota project and obtaining a detailed overview of the possible relationship between gut microbiota development and aging. Our findings confirmed the main stages in microbial richness development and revealed specific core microbiota associated with different age stages. Moreover, the shotgun metagenomic approach allowed the disentangling of the functional changes in the microbiome across the human life span, particularly in diet-related metabolism, which is probably correlated to bacterial co-evolution with dietary habits. Notably, our study also uncovered positive correlations with vitamin synthesis in early life, suggesting a possible impact of the microbiota on human physiology.

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Comparison between frail and non-frail older adults’ gut microbiota: A systematic review and meta-analysis

Cited by 15 publications

References 84 publications

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

Gut microbiome in healthy aging versus those associated with frailty

Taxonomic and metabolic development of the human gut microbiome across life stages: a worldwide metagenomic investigation

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