Comparison between findings of saline infusion sonohysterography and office hysteroscopy in patients with recurrent implantation failure

Reda, Ahmed; Hamid, Ahmed Sherif Abdel; Mostafa, Rowaa A.; Refaei, Eman

doi:10.4103/0974-1208.197661

Cited by 10 publications

(20 citation statements)

References 26 publications

(28 reference statements)

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“…However, in the majority of cases, the cause of RIF remains unknown. 1,6,7 MicroRNAs (miRNAs) are a class of small (approximately 18*22 nucleotide) noncoding RNAs that are critical for the regulation of gene expression. These RNA species mediate posttranscriptional gene expression by binding to the 3 0 -untranslated regions (UTRs), of target mRNAs in a sequence dependent manner, leading to transcript degradation and translational repression.…”

Section: Introductionmentioning

confidence: 99%

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Association Between miR-605 A>G, miR-608 G>C, miR-631 I>D, miR-938 C>T, and miR-1302-3 C>T Polymorphisms and Risk of Recurrent Implantation Failure

et al. 2019

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Recurrent implantation failure (RIF) is diagnosed when pregnancy failure occurs after 2 consecutive in vitro fertilization-embryo transfers (IVF-ET) to the endometrium using at least 4 high-quality embryos. MicroRNAs (miRNAs) are a class of small noncoding RNA and reported to play an important role in cell proliferation as well as implantation process. Recently, it has been reported that miRNA can regulate RIF occurrence. So, we were to examine the association between the specific miRNA polymorphisms and RIF in Korean women. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay to determine the frequency of the following polymorphisms: miR-605A>G, miR-608G>C, miR-631I>D, miR-938C>T, and miR-1302-3C>T. Our results demonstrate a decreased incidence of RIF in patients with the miR-1302-3C>T polymorphism (adjusted odds ratio [AOR], 0.234; 95% confidence interval [CI], 0.089-0.618; P = .003). Based on our allele combination analysis, the C-T ( miR-938/ miR-1302-3: OR = 0.259; 95% CI, 0.100-0.674; P = .003) allele was also associated with decreased RIF risk. From our interaction analysis with miR-1302-3, the miR-1302-3CC genotype (AOR = 43.332; 95% CI, 5.576-336.745) showed an association with RIF prevalence in participants with an activated partial thromboplastin time (aPTT) ≤22.6. We found that the miR-1302-3C>T polymorphism is significantly associated with RIF development in Korean women. Specifically, our study suggests that the T allele of miR-1302-3 may decrease the risk of RIF in Korean women.

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Section: Introductionmentioning

confidence: 99%

“…However, in the majority of cases, the cause of RIF remains unknown. 1,6,7…”

Section: Introductionmentioning

confidence: 99%

Association Between miR-605 A>G, miR-608 G>C, miR-631 I>D, miR-938 C>T, and miR-1302-3 C>T Polymorphisms and Risk of Recurrent Implantation Failure

et al. 2019

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“…Separate trials are needed to establish/compare its efficacy with hysteroscopy. Studies comparing SIS with diagnostic hysteroscopy have confirmed that SIS is a reliable alternative (18,19) . We see no reason for which it should not detect residual polyps on scanning after ultrasound guided D &C.…”

Section: Discussionmentioning

confidence: 96%

Fertility outcome after saline sonography guided removal of intrauterine polyps in women with unexplained infertility

Izhar

Husain

Tahir³

et al. 2019

J Ultrason

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ObjectiveTo assess the effect of removal of unsuspected polyps as delineated on saline sonography on the clinical pregnancy rate in women with unexplained infertility.MethodologyA prospective case control study was being conducted from 1st October 2016 to 30th September 2018 at Aziz Medical Centre, Karachi. Women diagnosed with unexplained infertility and unsuspected polyps revealed on saline sonography were included as cases (Group A). They were offered removal of polyps under ultrasound guidance and general anesthesia. Saline sonography was repeated at the time to ensure complete removal (Izhar’s Modification). Those with unsuspected polyps on saline sonography, but who refused the intervention, were classified as controls (Group B). Both groups were followed for one year. The primary outcome measure was women who had clinical pregnancy i.e. fetal heartbeat present on transvaginal scan during the follow up period.ResultsDuring the study period, out of 92 cases, 37 (40.2%) conceived and out of 92 controls, 10 (10.9%) conceived, which proved that polypectomy increased the chances of conception four-fold (p <0.001). The mean time to conception was also significantly lower for cases than controls (9.26 ± 3.928 months vs. 11.33 ± 2.07 months, p <0.001). The cumulative pregnancy rate was significantly higher in the polypectomy group (log-rank test, p <0.001). The duration of infertility (p = 0.007), position of polyp (p = 0.049) and polypectomy (p <0.001) influenced pregnancy rate.ConclusionsOur study shows the beneficial effect of removal of polyps. Women are four times more likely to conceive spontaneously after polypectomy.

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“…Study comparing Saline Infusion Sonography (SIS) and hysteroscopy for detection of uterine abnormalities concluded that these abnormalities were significantly less likely to be identified with SIS compared to hysteroscopy (P = 0.002). 15 …”

Section: Discussionmentioning

confidence: 99%

Establishing patterns on hysteroscopy in abnormal uterine bleeding (AUB)

Pandey

Kunamneni

Inukollu

et al. 2017

Gynecology and Minimally Invasive Therapy

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Introduction:Pattern recognition of various phases of normal endometrium and endometrial pathologies during hysteroscopy has many advantages. It would help to triage women with AUB, so as to be selective with biopsies and curettages. Recognition of normal variant or benign lesion would reduce burden to the pathologist by decreasing the number of unnecessary sampling. It will also decreases anxiety of the patient as the report/prognostication can be instant in many cases.Material and methods:This prospective, double blind, correlation study was carried out in the teaching hospital with a sample population of 70 women presenting with AUB who underwent hysteroscopy and endometrial sampling. We identified patterns of endometrium which can used to predict six endometrial pathologies which were later correlated with the final histological diagnosis.Results:There was good correlation between hysteroscopic patterns and histopathology report, 33% of starry sky appearance correlated with atrophic endometrium, 87% of tongue shaped projections correlated with endometrial polyp, 44.4% of pebble stone appearance correlated with myomatous polyp, 50% of polypoidal pattern correlated with endometrial hyperplasia. 100% correlation was seen in strawberry appearance, pattern for secretory endometrium and cerebroid appearance which was pattern designated to endometrial carcinoma.Conclusion:Hysteroscopic pattern recognition is a useful concept to triage women who require sampling for histopathological diagnosis.

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Comparison between findings of saline infusion sonohysterography and office hysteroscopy in patients with recurrent implantation failure

Cited by 10 publications

References 26 publications

Association Between miR-605 A>G, miR-608 G>C, miR-631 I>D, miR-938 C>T, and miR-1302-3 C>T Polymorphisms and Risk of Recurrent Implantation Failure

Association Between miR-605 A>G, miR-608 G>C, miR-631 I>D, miR-938 C>T, and miR-1302-3 C>T Polymorphisms and Risk of Recurrent Implantation Failure

Fertility outcome after saline sonography guided removal of intrauterine polyps in women with unexplained infertility

Establishing patterns on hysteroscopy in abnormal uterine bleeding (AUB)

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