Comparison between excessive grooming induced by bombesin or by ACTH: The differential elements of grooming and development of tolerance

Animal Models of Obsessive-Compulsive Behavior: A Neurobiological and Ethological Perspective

“…An overview explanation for the pathogenesis of OCD is that genetic susceptibility, in the face of anxiety or stress, promotes the release of opioid precursors and ACTH, activating a cascade of neurophysiological events that prime dopaminergic, noradrenergic, and/or glutamatergic excitatory pathways (Van Wimersma Greidanus, et al, 1985). The compulsion ultimately arising will be governed by the brain region and neurotransmitter system activated.…”