Comparison Between Effect of Intravenous Lignocaine and Ketamine in Alleviating Propofol Injection Pain in Patients Undergoing Surgeries Under General Anaesthesia

Abstract

Background: Propofol is the most commonly used intravenous inducing agent. Sharp, burning or aching pain on injection is a major problem. The cardiovascular response to the pain can aggravate adverse events in patients with history of coronary artery disease Small boluses of ketamine, magnesium, dexmedetomidine, ondansetron, dexamethasone, lignocaine hydrochloride, ketorolac, metoclopramide and opioids have been tried. To compare analgesic effe Aim: cts of using intravenous ketamine and lignocaine in alleviating pain following propofol injection. A prospective randomized double blinded st Methods And Material: udy was conducted in Chettinad Hospital and Research Institute, Kelambakkam among 50 participants undergoing surgeries under general anesthesia. Tourniquet was applied midarm ,Group L was given 21.3mg of 2% lignocaine and Group K was given 15mg of ketamine. Tourniquet was removed after 30seconds and then 1/3rd dose of total dose of 2mg/kg propofol was given. Degree of injection pain was evaluated using Mccririck Hunter scale. Results: Pain score on propofol injection was similar in both groups. Among the patients, 54% reported no pain,in that 76% patients were in Group L and 52% patients in Group K. McCRIRICK AND HUNTER PAIN SCALE rating between two groups are similar with the p value of more than 0.05. The pre-treatment of 15mg ketamine is as effective as 21.3mg 2% l Conclusions: ignocaine in reducing the severity of propofol injection pain.