Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area

Kotani, Tomoya; Nishimura, Motoki; Tamaki, Nagara; Matsushima, Shigenori; Akiyama, Shimpei; Kanayama, Taisei; Bamba, Chisa; Tanada, Yasutomo; Nii, Takeshi; Yamada, Kazuo

doi:10.1007/s12149-021-01671-y

Cited by 8 publications

(10 citation statements)

References 25 publications

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“…[ 7 , 19 , 20 ] In addition, there were also significant difference in early imaging time of some studies, and the early imaging time and delayed time of different studies might overlap. [ 21 , 22 ] The difference of imaging time might be the main reasons for the inconsistent results.…”

Section: Discussionmentioning

confidence: 99%

Comparison of 18F-FDG PET/CT imaging with different dual time 18F-FDG PET/CT with forced diuresis in clinical diagnosis of prostate cancer

Huang

et al. 2023

Medicine

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The aim of this study was to compare the capability of different dual time (interval 1, 2, 3, or 4 hours) 18F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) with forced diuresis to diagnose prostate cancer (PCa). A retrospective review of 273 male patients from March 2009 to June 2019, with any focal 18 F-FDG uptake in the prostate gland during PET/CT imaging. Early PET/CT imaging was performed 60 minutes after FDG injection. Delayed imaging was performed 1 to 4 hours after diuretic injection. For prostate lesions with increased 18 F-FDG uptake, a spheroid-shaped volume of interest was drawn, including the entire lesion, and the maximum standard uptake value (SUVmax) of the lesion was measured. The SUVmax > 2.5 after delayed imaging and the retention index > 15% were used as the diagnostic criteria for PET/CT in the diagnosis of PCa. Otherwise, it was diagnosed as the benign prostate disease. The final diagnosis was based on histological examination, associated imaging studies, or/and clinical follow-up. The results of inter-group comparison showed that the SUVmax of 1-, 2-, 3-, and 4-hour delayed imaging after diuresis in PCa group was significantly higher than that in control group ( P < .05), but there was no statistical difference in SUVmax of early imaging between PCa and control group ( P > .05). And the retention index of PCa group that delayed 1, 2, 3, and 4 hours after diuresis were significantly higher than those of control group, respectively ( P < .05). The diagnostic sensitivity of imaging delayed 1, 2, 3, and 4 hours after diuresis was 68.8%, 81.2%, 85.7 %, and 71.4%, the specificity was 52.5%, 74.5%, 70.6%, and 65.0%, and the accuracy was respectively 58.2%, 77.4%, 76.4%, and 67.6%, the positive predictive values were 44.0%, 68.9%, 64.3%, and 58.8%, and the negative predictive value were 75.6%, 85.4%, 88.9%, and 76.5%, respectively. 18 F-FDG PET/CT imaging as an imaging tool lacks certain specificity in the diagnosis of PCa, regardless of whether the imaging is delayed. The main advantage of delayed diuretic imaging in PCa is that it can significantly improve the sensitivity, especially the diagnostic effect delayed 2 hours after diuresis is better.

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Section: Discussionmentioning

confidence: 99%

Comparison of 18F-FDG PET/CT imaging with different dual time 18F-FDG PET/CT with forced diuresis in clinical diagnosis of prostate cancer

Huang

et al. 2023

Medicine

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“…The use of dynamic imaging to assess temporal changes in FDG uptake has several clinical advantages over static imaging. Continuous assessment of changes in FDG uptake, even over short periods of time, can help distinguish pathological uptake, particularly in the abdominal region [27].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Patlak parametric imaging in the diagnosis of liver cancer

Wang

Shi

Yan

et al. 2023

Preprint

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Conclusion Whole-body dynamic 18F-FDG PET/CT parameters are of great value in the differential diagnosis of benign and malignant liver lesions. Whole-body dynamic 18F-FDG PET/CT is more sensitive than whole-body static 18F-FDG PET/CT in the differential diagnosis of liver malignancy.Using reliable Patlak graphical analysis, whole-body dynamic PET/CT parametric imaging can achieve comparable or potentially better lesion detection capabilities than static SUV imaging. Background To investigate the value of whole-body dynamic 18F-FDG PET/CT parametric imaging in the differential diagnosis of liver-occupying lesions. Methods Eighty-one patients with hepatic occupancies were selected for whole-body dynamic PET/CT examinations. The imaging characteristics of Patlak parameter images of patients in the benign and malignant liver groups and patients with different pathological types of hepatic malignancies were analysed and compared, and the results were statistically analysed. Results Among 81 patients, SUVmax,Kimax,TBRSUV and TBRKi showed statistically significant differences in the benign liver groups and the malignant liver groups. (SUVmax: t =-13.020, P<0.001; Kimax: t =-12.984, P<0.001; TBRSUV: t =-10.541, P<0.001; TBRKi: t=-7.536, P<0.001). Among 67 cases in liver malignancy, the TBRKi values were higher than TBRSUV according to the results of the box plot analysis. Pearson correlation analysis showed that SUVmax was positively correlated with Kimax (r=0.882, P<0.01) and TBRSUV was positively correlated with TBRKi (r=0.848, P<0.01),respectively.The sensitivity and specificity of SUVmax, Kimax, TBRSUV and TBRKi in the diagnosis of primary liver cancer and liver metastases were 84.0% 65.7%, 68.0% 88.6%, 64.0% 85.1% ,92.0% and 68.6%, respectively.

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“…Recently, some studies have reported [16,17] that the visual evaluation of changes in the shape and distribution of 18 F-FDG uptake on 4-phase WBD-PET images enabled discrimination between pathological and physiological uptake in the abdominal region, and had higher diagnostic performance (sensitivity, 97%; speci city, 76%; and accuracy, 68%) than DTP-PET [17]. The diagnostic performance of WBD-PET images in this study was comparable to the sensitivity of previous studies that visually evaluate changes in the distribution and shape of 18 F-FDG uptake on WBD-PET images; however, the speci city and accuracy were higher.…”

Section: Discussionmentioning

confidence: 99%

“…WBD-PET imaging, a short-term Whole-body PET scan repeatedly, can detect dynamic PET images with multi-phase information in only one scanning and can obtain conventional early PET (early) images by summation of multiple phases of dynamic PET images. Using WBD-PET to visually evaluate changes in the distribution and shape of 18 F-FDG uptake, WBD-PET images were found to have higher diagnostic performance (sensitivity, 95% and 97%; speci city, 61% and 76%; and accuracy, 84% and 68%, respectively) than early images alone [16] or DTP-PET [17] in abdominal region. However, visual evaluation of distribution and shape changes in 18 F-FDG uptake is expected to cause discrepancies in judgment among evaluators and depend on the reading skills of the diagnostician, and therefore, more objective index should be used.…”

Section: Introductionmentioning

confidence: 99%

A noble objective method for discriminating pathological and physiological colorectal uptake in the lower abdominal region using whole-body dynamic 18F-FDG-PET

Kato

Ichikawa

Shibutani

et al. 2023

Preprint

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Objectives To investigate whether the center-of-mass shift distance (CMSD) analysis on whole-body dynamic positron emission tomography (WBD-PET) with continuous bed motion was an objective index for discriminating pathological and physiological colorectal uptake in the lower abdominal region. Methods We retrospectively analyzed the CMSD in 39 patients who underwent delayed imaging to detect focal uptake that were difficult to determine as pathological and physiological on an conventional early PET (early) image reconstructed by five-phase WBD-PET images. The CMSD between each phase of WBD-PET images and between early to delayed (early–delayed) images were classified into pathological and physiological uptake groups based on endoscopic histology or other imaging diagnostics. The diagnostic performance of CMSD analysis on WBD-PET images was evaluated by receiver operator characteristic (ROC) analysis and compared to that of early–delayed images. Results A total of 66 focal uptake detected early image were classified into 17 and 49 pathological and physiological uptake groups, respectively. The CMSD on WBD-PET and early–delayed images in the pathological uptake group was significantly lower than that in the physiological uptake group (p < 0.01), respectively. The sensitivity, specificity, and accuracy in CMSD analysis on WBD-PET images at the optimal cutoff of 5.2 mm estimated by the Youden index were 94.7%, 89.4%, and 89.4%, respectively, which were not significantly different (p = 0.74) from those of early–delayed images. Conclusions The CMSD analysis on WBD-PET was useful in discriminating pathological and physiologicalcolorectal uptake in the lower abdominal region, and its diagnostic performance is comparable to that of early–delayed images. We suggested that CMSD analysis on WBD-PET images would be a new objective method to omit unnecessary additional delay imaging.

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Comparison between dynamic whole-body FDG-PET and early-delayed imaging for the assessment of motion in focal uptake in colorectal area

Cited by 8 publications

References 25 publications

Comparison of 18F-FDG PET/CT imaging with different dual time 18F-FDG PET/CT with forced diuresis in clinical diagnosis of prostate cancer

Comparison of 18F-FDG PET/CT imaging with different dual time 18F-FDG PET/CT with forced diuresis in clinical diagnosis of prostate cancer

Feasibility of Patlak parametric imaging in the diagnosis of liver cancer

A noble objective method for discriminating pathological and physiological colorectal uptake in the lower abdominal region using whole-body dynamic 18F-FDG-PET

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