Comparison Between Different Manufacturers’ 2-D and Point Shear Wave Elastography Techniques in Staging Liver Fibrosis in Chronic Liver Disease Using Liver Biopsy as the Reference Standard: A Prospective Study

Fang, Cheng; Rafailidis, Vasileios; Konstantatou, Eleni; Yusuf, Gibran Timothy; Barrow, Ian; Pagkalidou, Eirini; Romanos, Odyssefs; Agarwal, Kosh; Quaglia, Alberto; Sidhu, Paul S.

doi:10.1016/j.ultrasmedbio.2022.06.009

Cited by 3 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study found that 2D-SWE had fewer unreliable measurements than p-SWE, which is consistent with the findings of previous studies [25,28]. This may be due to the larger elastographic box with color coding in 2D-SWE, which allows for more appropriate placement of ROIs away from the artifact areas.…”

Section: Discussionsupporting

confidence: 91%

“…Several studies have shown that LS values obtained using supersonic shear imaging are strongly correlated with the fibrosis stage based on histology. Furthermore, it has demonstrated comparable or better diagnostic accuracy than p-SWE and TE in discriminating between significant fibrosis and cirrhosis, using liver biopsy as the reference standard [22,23,26,28,29]. However, ElastQ imaging, the latest 2D-SWE technique used in our study, has not yet been extensively validated.…”

Section: Discussionmentioning

confidence: 86%

“…However, limited available data suggest that 2D-SWE, a relatively newer technique, may have superior diagnostic accuracy compared with p-SWE [25][26][27]. Additionally, few published studies have validated the diagnostic performance of 2D-SWE for staging liver fibrosis using histology as the reference standard [28].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison between Two-Dimensional and Point Shear Wave Elastography Techniques in Evaluating Liver Fibrosis Using Histological Staging as the Reference Standard: A Prospective Pilot Study

Lee

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Evaluation of hepatic fibrosis is essential to prevent liver-related morbidity and mortality. Although various types of ultrasound shear wave elastography (SWE) have been used and validated, there are limited studies on the relatively newer technique, two-dimensional SWE (2D-SWE). Therefore, this study aimed to compare the diagnostic performances of 2D-SWE and point SWE (p-SWE) for evaluating liver fibrosis using histology as the reference standard. To measure liver stiffness (LS) values, 87 patients underwent 2D-SWE and p-SWE using the same machine. Technical failures and unreliable measurements were also evaluated. The diagnostic performances of 2D-SWE and p-SWE were compared using area under the receiver operating characteristic (AUROC) curve analysis. No technical failures were observed in either method; however, unreliable measurements were less frequent in 2D-SWE (1/87 [1.1%]) than in p-SWE (8/87 [9.2%]) (p < 0.001). The AUROC of the LS values of 2D-SWE were significantly higher than those of p-SWE for diagnosing significant fibrosis (0.965 vs. 0.872, p = 0.022) and cirrhosis (0.994 vs. 0.886, p = 0.042). In conclusion, 2D-SWE is more reliable and accurate than p-SWE for diagnosing hepatic fibrosis.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Comparison between Two-Dimensional and Point Shear Wave Elastography Techniques in Evaluating Liver Fibrosis Using Histological Staging as the Reference Standard: A Prospective Pilot Study

Lee

et al. 2023

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Comparable findings for 2D SWE were reported in similar populations. 24 The different elastography techniques are safe to perform, with no added risk for the patients, and are cost-efficient. Importantly, pSWE and 2D SWE have the potential to save costs as compared with VCTE as they are integrated with the ultrasound imaging system routinely used for standard of care in liver units.…”

Section: Discussionmentioning

confidence: 99%

The deep abdominal ultrasound transducer (DAX) increases the success rate and diagnostic accuracy of shear wave elastography for liver fibrosis assessment in patients with obesity—A prospective biopsy‐controlled study

Bauer,

Nixdorf,

Dominik

et al. 2024

Aliment Pharmacol Ther

View full text Add to dashboard Cite

SummaryBackgroundObesity impacts the diagnostic accuracy of shear wave elastography (SWE). A deep abdominal ultrasound transducer (DAX) capable of point (pSWE) and two‐dimensional (2D)‐SWE has recently been introduced to address this issue.MethodsWe performed a prospective study in a cohort of mostly patients with obesity undergoing liver biopsy with a high prevalence of metabolic dysfunction‐associate steatotic liver disease (MASLD). Liver stiffness measurement (LSM) was measured using vibration‐controlled transient elastography (VCTE), as well as pSWE and 2D SWE on the standard (5C1) and the DAX transducers.ResultsWe included 129 patients with paired LSM and liver biopsy: median age 44.0 years, 82 (63.6%) women, median BMI: 43.2 kg/m2. Histologic fibrosis stages: F0: N = 55 (42.6%), F1: N = 14 (10.9%), F2: N = 50 (38.8%), F3: N = 2 (1.6%), F4: N = 8 (6.2%). VCTE‐LSM failed (N = 13) or were unreliable (IQR/median ≤30% in ≥7.1 kPa, N = 14) in 20.9% of patients. The Pearson correlation of reliable VCTE‐LSM with both pSWE and 2D SWE was strong (all >0.78). The diagnostic accuracy for all LSM techniques was poor for significant fibrosis (≥F2, AUC: 0.54–0.63); however, it was good to excellent for advanced fibrosis (≥F3, AUC: 0.87–0.99) and cirrhosis (F4, AUC: 0.86–1.00). In intention‐to‐diagnose analysis, pSWE on DAX was significantly superior to VCTE‐LSM.ConclusionspSWE‐ and 2D‐SWE enable the non‐invasive identification of advanced fibrosis and cirrhosis in patients with obese MASLD. The use of the DAX transducer for acoustic radiation force imaging (ARFI)‐LSM avoids technical failures in an obese population and subsequently offers advantages over VCTE‐LSM for the evaluation of fibrosis in an obese MASLD population at risk for fibrosis.

show abstract

“…Ultrasound elastography, especially quantitative shear wave elastography (SWE), plays an important role in hepatic imaging[ 15 - 17 ]. Compared with CEUS, contrast-enhanced computed tomography, or contrast-enhanced MRI, SWE has the advantage of the absence of contrast agent allergy and is generally less expensive and less time-consuming than other methods, making it a more practical option for many medical facilities.…”

Section: Introductionmentioning

confidence: 99%

Preoperative prediction of microvascular invasion in hepatocellular carcinoma using ultrasound features including elasticity

Jiang,

Qian,

Tan

et al. 2023

World J Gastrointest Surg

View full text Add to dashboard Cite

Indocyanine green (ICG) is a water-soluble fluorescent dye that is minimally toxic and widely used in gastrointestinal surgery. ICG facilitates anatomical identification of structures (e.g., ureters), assessment of lymph nodes, biliary mapping, organ perfusion and anastomosis assessment, and aids in determining the adequacy of oncological margins. In addition, ICG can be conjugated to artificially created antibodies for tumour markers, such as carcinoembryonic antigen for colorectal, breast, lung, and gastric cancer, prostate-specific antigen for prostate cancer, and cancer antigen 125 for ovarian cancer. Although ICG has shown promising results, the optimization of patient factors, dye factors, equipment, and the method of assessing fluorescence intensity could further enhance its utility. This review summarizes the clinical application of ICG in gastrointestinal surgery and discusses the emergence of novel dyes such as ZW-800 and VM678 that have demonstrated appropriate pharmacokinetic properties and improved target-to-background ratios in animal studies. With the emergence of robotic technology and the increasing reporting of ICG utility, a comprehensive review of clinical application of ICG in gastrointestinal surgery is timely and this review serves that aim.

show abstract

Comparison Between Different Manufacturers’ 2-D and Point Shear Wave Elastography Techniques in Staging Liver Fibrosis in Chronic Liver Disease Using Liver Biopsy as the Reference Standard: A Prospective Study

Cited by 3 publications

References 20 publications

Comparison between Two-Dimensional and Point Shear Wave Elastography Techniques in Evaluating Liver Fibrosis Using Histological Staging as the Reference Standard: A Prospective Pilot Study

Comparison between Two-Dimensional and Point Shear Wave Elastography Techniques in Evaluating Liver Fibrosis Using Histological Staging as the Reference Standard: A Prospective Pilot Study

The deep abdominal ultrasound transducer (DAX) increases the success rate and diagnostic accuracy of shear wave elastography for liver fibrosis assessment in patients with obesity—A prospective biopsy‐controlled study

Preoperative prediction of microvascular invasion in hepatocellular carcinoma using ultrasound features including elasticity

Contact Info

Product

Resources

About