Comparison Between Child-Turcotte-Pugh and Albumin-Bilirubin Scores in Assessing the Prognosis of Hepatocellular Carcinoma After Stereotactic Ablative Radiation Therapy

Lo, Cheng‐Hsiang; Liu, Ming-Yueh; Lee, Meei-Shyuan; Yang, Juxiang; Jen, Yee‐Min; Lin, Chun–Shu; Chao, Hsing‐Lung; Shen, Po-Chien; Huang, Wen‐Yen

doi:10.1016/j.ijrobp.2017.04.036

Cited by 33 publications

(43 citation statements)

References 24 publications

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“…Most patients of ALBI grade 1 had CTP score A. The majority (27 of 33) of CTP class B patients were ALBI grade 2 and all ALBI grade 3 patients were also CTP class B [24]. While correlating ALBI grade 1 and 2 with CTP class A and B, our result nearly similar with this study.…”

Section: Discussionsupporting

confidence: 88%

"Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis "

Shafiq¹,

Khan²,

Majumder³

et al. 2019

AJLM

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Cirrhosis of liver is characterized by the replacement of normal liver tissue by scar tissue. The Child-Turcotte-Pugh (CTP) score is used to assess the prognosis of cirrhosis and included five factors: total bilirubin level, serum albumin, prothrombin time, ascites and hepatic encephalopathy. CTP score depends on clinical assessment which may result variation in scoring. Recently a new score is introduced, Albumin-Bilirubin (ALBI) score which may be done instead of CTP scoring in cirrhotic patient. This cross sectional study was conducted at the Department of Laboratory Medicine in collaboration with the Department of Hepatology, BSMMU, Dhaka, from March 2018 to February 2019. Blood samples were assayed from eighty one diagnosed cirrhotic patients. For all statistical analysis SPSS version 22 was used. The mean age of the study group was 46.1±16.0 years. 64.2% were male and 35.8% were female. Kappa (k) value was 0.759 between ALBI and CTP score. Pearson's correlation coefficient (r) test showed significant strong positive correlation between CTP score and ALBI score (r=+0.853, p<0.001). This study concluded that the ALBI score may be done alternative to the CTP score in cirrhotic patient because it's simple, two parameters only, more evidence based and more objective.

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Section: Discussionsupporting

confidence: 88%

"Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis "

Shafiq¹,

Khan²,

Majumder³

et al. 2019

AJLM

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“…This study showed for the first time that ALBI grade can better stratify these patients. Their results have also been confirmed by Oh Is et al 41 and CH Lo et al 42 Also, our meta-analysis confirms that ALBI grade is currently one of the best indexes for predicting survival in this patient subset. As shown by other works at different disease stages, 43 – 45 ALBI grade is better predictive index than Child–Pugh, as the latter is composed of 5 arbitrary parameters, whereas the former is formed by only 2 non-arbitrary parameters (albumin and bilirubin).…”

Section: Discussionsupporting

confidence: 87%

“…Figure 1 reports the search strategy used in this meta-analysis. Thirty-four 9 – 42 studies published between 2003 and 2017 were analyzed. They included 11,216 HCC patients treated with RFA.…”

Section: Resultsmentioning

confidence: 99%

Radiofrequency Ablation of hepatocellular carcinoma: a meta-analysis of overall survival and recurrence-free survival

Casadei-Gardini¹,

Marisi²,

Canale³

et al. 2018

OTT

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Background and aimsSo far, no randomized trial or meta-analysis has been conducted on overall survival (OS) and recurrence-free survival (RFS) factors in patients treated with radiofrequency ablation (RFA) alone. The purpose of this meta-analysis was to evaluate prognostic factors of OS and RFS in patients treated with RFA.MethodsA primary analysis was planned to evaluate the clinical prognostic factor of OS. RFS was the secondary aim. Thirty-four studies published from 2003 to 2017 were analyzed. They included 11,216 hepatocellular carcinoma patients.ResultsThe results showed that Child–Pugh B vs Child–Pugh A (HR =2.32; 95% CI: 2.201–2.69; P<0.0001) and albumin–bilirubin score 1 vs 0 (HR =2.69; 95% CI: 2.10–3.44; P<0.0001) were predictive of poor OS. Tumor size as a continuous variable was not predictive of OS, although it was predictive of OS when we considered the size as a cutoff value (.2 cm vs <2 cm: HR =1.41; 95% CI: 1.23–1.61; P<0.0001; >3 cm vs <3 cm: HR =1.43; 95% CI: 1.17–1.74; P<0.0001) and in presence of >1 nodule (HR =1.59; 95% CI: 1.46–1.74; P<0.0001). Alpha-fetoprotein >20 ng/mL (HR =1.46; 95% CI: 1.25–1.70; P<0.0001) was the only predictive factor of poor prognosis.ConclusionOur meta-analysis highlighted that the maximum benefit of RFA in terms of OS and RFS is reached in the presence of Child–Pugh A, albumin–bilirubin score 1, single-nodule tumor sized <2 cm, and alpha-fetoprotein <20 ng/mL.

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“…In keeping with this current study, however, baseline CP was also not found to be a significant predictor of OS 20 . A recent retrospective analysis of Taiwanese HCC patients treated with SBRT found ALBI grade 2 vs. 1 to be a significant predictor of OS on univariate (but not multivariable) analysis and both ALBI and CP were found effective in predicting radiation-induced liver disease 21 . The retrospective nature, shorter median follow-up and smaller proportion (38%) of patients with macrovascular invasion in the above analysis make this a different population to the prospective series presented here.…”

Section: Discussionmentioning

confidence: 98%

Baseline Albumin-Bilirubin (ALBI) Score in Western Patients With Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy (SBRT)

Murray

Sykes

Brierley

et al. 2018

International Journal of Radiation Oncology*Biology*Physics

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Comparison Between Child-Turcotte-Pugh and Albumin-Bilirubin Scores in Assessing the Prognosis of Hepatocellular Carcinoma After Stereotactic Ablative Radiation Therapy

Cited by 33 publications

References 24 publications

"Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis "

"Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis "

Radiofrequency Ablation of hepatocellular carcinoma: a meta-analysis of overall survival and recurrence-free survival

Baseline Albumin-Bilirubin (ALBI) Score in Western Patients With Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy (SBRT)

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Comparison Between Child-Turcotte-Pugh and Albumin-Bilirubin Scores in Assessing the Prognosis of Hepatocellular Carcinoma After Stereotactic Ablative Radiation Therapy

Cited by 33 publications

References 24 publications

&quot;Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis &quot;

&quot;Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis &quot;

Radiofrequency Ablation of hepatocellular carcinoma: a meta-analysis of overall survival and recurrence-free survival

Baseline Albumin-Bilirubin (ALBI) Score in Western Patients With Hepatocellular Carcinoma Treated With Stereotactic Body Radiation Therapy (SBRT)

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"Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis "

"Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis "