“…Numerous evaluations have considered the relationship between the capability of chemicals to induce tumors in rodents and to induce mutation or other types of genetic toxicity [eg, Bartsch and Tomatis, 1983;Bridges, 1976;McCann et al, 1975;Hollstein et al, 1979;Rinkus and Legator, 1979;Butterworth, 1979;Purchase et al, 1978;Reitz et al, 19821. It is clear that this relationship is complex, and at this time there are a number of discordant results that preclude the use of in vitro genetic toxicity results to predict all potential in vivo carcinogens in a reliable manner.…”