Comparison between Benign and Malignant Primary Bone Tumors-A Histopathological Study of 119 Cases

Hasan, Farah; Mohammed, Haider Lateef

doi:10.23851/mjs.v29i2.182

Cited by 2 publications

(2 citation statements)

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“…12 In present study we evaluate 68 cases of neoplastic lesions of bone, we observed that these lesions are more common in younger persons between 20 -40 years of age, as observed by other studies 13 and the male (60.3%) were found affected more than the females, this was also the observation of other researchers mentioned in the literature. 1,7,10,14 We detect majority of benign (63.2%) cases in our study, which was in consistent with the findings of other studies 10,13,15 some studies showed a very high (84%) frequency of benign tumors 16 , these differences may be due to differences in sample size and selection criteria. Among 43 benign tumors, we diagnose majority (25.6%) of cases as osteochondroma followed by 21 % cases of Benign Giant Cell Tumor.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of neoplastic bone lesions: A morphological study at a tertiary care centre.

Shah

Naqvi²,

Shah

et al. 2019

TPMJ

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Objectives: To determine the pattern and frequency of various bone tumors at a tertiary care centre in rural area. Study Design: Retrospective study. Setting: Orthopaedic Peoples University of Medical and Health Sciences (PUMHS), Nawabshah. Period: June to December 2018. Material and Methods: The 5 years record from July 2015 to June 2018, of all the patients who were admitted and operated for any bone tumor was retrieved. A total of 68 cases were included in the study having complete file record, regardless of their age and sex, the histopathological report of their bone biopsy was mandatory for inclusion in the study. The patients of incomplete file record, without histopathological report and the cases of other bone non-neoplastic conditions were not included in the study. All the collected data was recorded on a proforma, analysed statistically and results were tabulated. Results: In present study 68 cases of bone tumors were evaluated. The patients were aged between 7.5 to 73 years with a mean of 26.4 + 12.7 years. Among these 68 cases 41 (60.3%) were male. The malignant tumors were diagnosed in 25 (36.8%) cases among these 14 (20.6%) cases in male patients and 11 (16.2%) cases in female. The overall benign tumors were observed in 43 (63.2%) cases, and among these 27 (39.7%) cases were male and 16 (23.5%) cases were female. Osteosarcoma was the most common malignant tumor diagnosed in 14/25 (56%) cases followed by chondrosarcoa in 4/25 (16%) cases. In benign tumors the osteochondroma was the commonest tumor detected in 11/43 (25.6%) cases followed by benign giant cell tumor which was diagnosed in 9/43 (21%) cases. Most of the malignant tumors (24%) were diagnosed in 11 - 20 years age group, and most of benign tumors were detected in 21-30 and 31- 40 age groups each comprising of 23.3% cases. Three cases of metastatic tumors were also diagnosed and all were present in older 61 – 70 years age group. Conclusion: The bone tumors are more common in males, occurred predominantly in the second decade of life. osteochondroma and osteosarcoma was the most common benign and malignant bone tumors. Metastatic lesions were observed in older age group.

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Section: Discussionsupporting

confidence: 91%

Evaluation of neoplastic bone lesions: A morphological study at a tertiary care centre.

Shah

Naqvi²,

Shah

et al. 2019

TPMJ

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“…Based on these findings, these cases in our study were re-diagnosed as high grade RMS. (23,24,25). It was evident that Desmin diffuse positive staining in four cases (8%) that could be due to the fact that Desmin is more specific for myogenic differentiation but it is less specific than Actin.…”

Section: Resultsmentioning

confidence: 98%

Soft tissue sarcomas: Evaluation by immunohistochemistry

Obaidi¹

2020

JFacMedBagdad

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Background: Soft tissue sarcomas (STS) are relatively rare tumors, representing less than 1% of adult malignancies based on report from American Cancer Society. The crude incidence rate in Iraq for soft tissue sarcomas was 219/ 100,000 populations during 2014 with a male: female ratio of 1.2:1, and the highest age peak falling between 30-34 years .The histological subtype and microscopic criteria are two parameters that influence the tumor grade which is the best predictor for aggressiveness. Objectives: A retrospective evaluation of soft tissue sarcomas, using immunohistochemical (IHC) study of Myosin, Desmin, Smooth muscle Actin (SMA) and Vimentin, aiming to review the primary diagnosis and whether IHC assessment in soft tissue sarcoma is mandatory to reach a final interpretation. Patients and methods: A total of 50 cases of soft tissue sarcomas were reviewed retrospectively from case archives of histopathology department/ Central Public Health Laboratory and Ghazi Al Hariri Hospital for Specialized Surgeries for the period (2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018). Hematoxylin and Eosin (H&E) stain and IHC staining of unstained sections from formalin-fixed, paraffin-embedded tissue were performed using SMA, Vimentin, Desmin and Myosin. The staining intensity was assessed based on the percentage of positive cell expression of the four IHC monoclonal antibodies. Results: The staining interpretation of the four monoclonal antibodies were confirmatory for the original diagnosis in 40% of cases, while 60% of the final diagnoses were re-evaluated and a different interpretation was given supported by the IHC findings for Desmin, Myosin, SMA and vimentin, under the clinical and radiological context. Conclusions: The co-expression of SMA and Desmin helped in the diagnosis of leiomyosarcoma (LMS). Myosin expression was helpful in the diagnosis of rhabdomyosarcoma (RMS) and alveolar soft part sarcoma (ASPS). SMA and Vimentin were not specific for the diagnosis of malignant fibrous histiocytoma (MFH). By applying IHC markers, 60% of soft tissue sarcomas were found to be different from the preliminary diagnosis while 40% of cases were supportive of the original H&E diagnosis.

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Comparison between Benign and Malignant Primary Bone Tumors-A Histopathological Study of 119 Cases

Cited by 2 publications

References 15 publications

Evaluation of neoplastic bone lesions: A morphological study at a tertiary care centre.

Evaluation of neoplastic bone lesions: A morphological study at a tertiary care centre.

Soft tissue sarcomas: Evaluation by immunohistochemistry

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