Comparison between a New Ultrasound Densitometer and Single-Photon Absorptiometry

Murgia, Cinzia; Cagnacci, Angelo; Paoletti, Anna Maria; Pilia, lsa; Meloni, Alessandro; Melis, Gian Benedetto

doi:10.1097/00042192-199603030-00006

Cited by 11 publications

(11 citation statements)

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“…Comparison of our AD-SoS values with those given by other authors provides further interesting information. For example, in 55-year-old women Murgia et al [17] observed an AD-SoS value of 2007 ± 74 m/s, while in our study it was 1942 ± 72 m/s. In 60-year-old women Sili Scavalli et al [19] reported 1962 ± 71 m/s, Aguado et al [18] 2006 ± 68 m/s, and in our study it was only 1903 ± 84 m/s.…”

Section: Discussioncontrasting

confidence: 72%

“…2). No such findings have been reported by other authors [15][16][17]. The correlation coefficient between AD-SoS and age in Polish postmenopausal women was -0.58 (p <0.0001), similar to that given by Sili Scavalli et al [19] r = -0.63 and higher than the value obtained by Duboeuf et al [16] r = -0.39.…”

Section: Discussionsupporting

confidence: 70%

“…In the study by Ventura et al [15], YSM caused a smaller decrease in AD-SoS (simple linear regression analysis equation: AD-SoS = -0.5 6 YSM + 2050.5, r = -0.42, p <0.0001) in comparison with our results (Table 4). Murgia et al [17] reported the correlation coefficient between ADSoS and YSM to be r = -0.52, and Sili Scavalli et al [19] found it to be r = -0.58.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the device automatically takes into account the amplitude (2 mV) of the signal present at the receiving probe, and hence an amplitude-dependent speed of sound (AD-SoS; in m/s) is calculated. Acoustic coupling was achieved using a standard ultrasound gel [15][16][17]. All measurements were done by the same technician.…”

Section: Methodsmentioning

confidence: 99%

“…The only commercially available ultrasound device that can be used for measurements of the proximal phalanges is the DBM Sonic 1200 (Igea, Italy). Several recent studies have shown that such measurements are able to detect bone changes due to aging and the menopause [15][16][17][18][19]. In these studies correlations, ranging from 0.43 to 0.69, between amplitude-dependent speed of sound (AD-SoS) and BMD measurement of spine, distal and ultradistal radius, metacarpals and total body were reported.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound Measurement of Proximal Phalanges in a Normal Polish Female Population

Pluskiewicz¹,

Drozdzowska²

1998

Osteoporosis International

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In this cross-sectional study 954 Polish healthy women aged 30-80 years were evaluated (mean age 50.8 +/- 8.9 years). Among them were 460 premenopausal (mean age 44.4 +/- 5.5 years) and 494 postmenopausal women (mean age 56.8 +/- 7.2 years). Women suffering from diseases known to affect bone metabolism and/or treated with drugs that affect bone tissue were excluded. All women were volunteers from six towns in the south of Poland, who underwent bone measurements for screening purposes. Bone status was assessed using an ultrasound device (DBM Sonic 1200, Igea, Italy) that measures amplitude-dependent speed of sound (AD-SoS) in metres per second. Phalanges (II-V) of the non-dominant hand were measured and an average value was computed. In vivo short-term precision was 0.49% for intraobserver, and 0.42% for interobserver measurements. Mean AD-SoS values were: in the whole group, 1974.6 +/- 90.7 m/s; in premenopausal women, 2032.1 +/- 50.0 m/s; and in postmenopausal women, 1921.0 +/- 87.3 m/s (p < 0.0001). The mean decrease in AD-SoS value in the studied population was 6.1 m/s per year. Simple linear regression analysis showed significant, negative correlations between age and AD-SoS: in the whole group r = -0.70 (p < 0.0001); in pre- and postmenopausal women, r = -0.29 (p < 0.0001) and r = -0.58 (p < 0.0001), respectively. Years since menopause (YSM) showed a significant influence on AD-SoS: linear correlation in the whole group resulted in a value of r = -0.59 (p < 0.0001) and in the group of postmenopausal women in a value of r = -0.57 (p < 0.0001). AD-SoS decreased in the first 8 YSM by 5.1% (0.63%/year) and in the next 15 YSM by 5.44% (0.36%/year). In postmenopausal women mean AD-SoS was regressed simultaneously on age and YSM, resulting in AD-SoS = 2181.0 - 4.031 x Age - 3.911 x YSM. In conclusion, ultrasound measurements of proximal phalanges were found to enable detection of age- and YSM-related skeletal changes in a Polish healthy female population. Results obtained in this study showed a premenopausal decrease in the ultrasound parameter (not observed by other authors) and an AD-SoS value lower than those in French, Italian and Spanish populations. The premenopausal decline in AD-SoS, the most important observation, requires further longitudinal investigations to determine factors affecting the skeleton before menopause.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrasound Measurement of Proximal Phalanges in a Normal Polish Female Population

Pluskiewicz¹,

Drozdzowska²

1998

Osteoporosis International

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Ultrasound transmission velocity of the proximal phalanxes of the non-dominant hand in the study of osteoporosis

et al. 1997

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The aim of our study was to evaluate a quantitative ultrasound technique for measuring bone tissue at the proximal phalanxes of the non-dominant hand. We correlated the mean value of the amplitude-dependent speed of sound (AD-SoS) measured at the distal metaphysis of the last four proximal phalanxes with age, months since menopause and bone mineral density (BMD) of the lumbar spine in 264 women. We further assessed the ability of the AD-SoS to discriminate between normal and osteoporotic subjects with documented vertebral fractures. We found a positive correlation between the AD-SoS and the lumbar spine BMD, whereas the AD-SoS negatively correlated with age and months since menopause. The AD-SoS showed a higher correlation with age changes and months since menopause than BMD. The AD-SoS was significantly higher in healthy females than in osteoporotic ones (p < 0.001). Multiple logistic regression analysis showed for age-adjusted values that AD-SoS decrease is significantly associated to the presence of fracture. Our results suggest that AD-SoS is valuable in assessing age and menopause related bone loss and is useful for diagnosing osteoporosis.

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Ultrasound Measurements of Proximal Phalanges in Polish Early Postmenopausal Women

Pluskiewicz

Drozdzowska²

1998

Osteoporosis International

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The aim of this cross-sectional study was to evaluate skeletal status in Polish early postmenopausal women using ultrasound measurement at the proximal phalanges of the hand. We assessed the ability of the method to discriminate between healthy and osteoporotic individuals, the influence of age and menopause on ultrasound values, the impact of hormone replacement therapy and the relationships between ultrasound measurement and type of fracture. Five hundred and three early postmenopausal women were divided into three groups: (1) healthy (n = 398, mean age 53.4 years), (2) fractured (n = 43, mean age 53.9 years), (3) treated with estrogens (n = 62, mean age 53.5 years). Groups were matched for age and years since menopause (YSM). Group 2 was subdivided into those with and without wrist fracture. No drugs except estrogens were used by the subjects studied and no diseases known to affect bone metabolism were observed. Bone status was assessed by a DBM Sonic 1200 (Igea, Italy), a device that measures amplitude-dependent speed of sound (AD-SoS) at the proximal phalanges II-V of the hand. AD-SoS had the highest value in estrogen-treated women (1996.5 +/- 66.5 m/s), the lowest in fractured persons (1883.6 +/- 77.1 m/s) and a medium value in healthy women (1949.2 +/- 78.0 m/s). All values were significantly different from each other (p < 0.0001). AD-SoS values for the subgroups of group 2 were 1873.0 +/- 80.6 m/s for those with wrist fracture and 1914.0 +/- 73.0 m/s for those without; they were not statistically different. The hypothesis that AD-SoS at the proximal phalanges might be more sensitive to wrist fracture was not confirmed by Fisher's exact test for frequencies. Linear regression showed age-related changes, with r values -0.4 (p < 0.00001), -0.47 (p < 0.005), -0.37 (p < 0.005), and YSM-related changes, with r values of -0.44 (p < 0.00001), -0.32 (p < 0.005), and -0.18 (NS) in groups 1, 2 and 3, respectively. It is concluded that: (1) ultrasound measurements of the proximal phalanges were able to discriminate between healthy and osteoporotic individuals; (2) the method is useful in detecting age and postmenopause-related changes within the skeleton; and (3) hormone replacement therapy significantly reduced the impact of the menopause on bone loss as detected by ultrasound.

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Comparison between a New Ultrasound Densitometer and Single-Photon Absorptiometry

Cited by 11 publications

References 0 publications

Ultrasound Measurement of Proximal Phalanges in a Normal Polish Female Population

Ultrasound Measurement of Proximal Phalanges in a Normal Polish Female Population

Ultrasound transmission velocity of the proximal phalanxes of the non-dominant hand in the study of osteoporosis

Ultrasound Measurements of Proximal Phalanges in Polish Early Postmenopausal Women

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