FPGA-specific primitive instantiation is an efficient approach for design optimization to effectively utilize the native hardware primitives as building blocks. Placement steps also need to be constrained and controlled to improve the circuit critical path delay. Here, the authors present optimized implementations of certain arithmetic circuits and pseudorandom sequence generator circuits to indicate the superior performance scalability achieved using the proposed design methodology in comparison to circuits of identical functionality realized using other existing FPGA CAD tools or design methodologies. The Hardware Description Language specifications as well as the placement constraints can be automatically generated. A GUI-based CAD tool has been developed that is integrated with the Xilinx Integrated Software Environment for design automation of circuits from user specifications.