Comparison and validation of point of care lactate meters as a replacement for fetal pH measurement

Ridenour, Robert V.; Gada, R.; Brost, Brian C.; Karon, Brad S.

doi:10.1016/j.clinbiochem.2008.08.088

Cited by 29 publications

(36 citation statements)

References 10 publications

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“…64 Lactate can be easily measured on a handheld device and this correlates in multiple studies with that measured with a laboratory-based analyser, making the process cheaper. 30,[76][77][78][79][80] Moreover, a system that reduces the amount of blood required to measure acidosis so significantly has the potential to decrease the amount of nonassessed cases secondary to inadequate sampling. 30 Not all neonates with acidosis at birth have adverse neurological outcomes, but the likelihood of poor outcome increases with progressive acidosis.…”

Section: Discussionmentioning

confidence: 99%

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

Allanson

Waqar

White

et al. 2016

BJOG

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Background Umbilical cord lactate is one approach to measuring acidosis and intrapartum hypoxia, knowledge of which may be helpful for clinicians involved in the care of women and newborns.Objective To synthesise the evidence on accuracy of umbilical cord lactate in measuring acidosis and predicting poor neonatal outcome.Search strategy Studies published and unpublished between 1990 and 2014 from PubMed/Medline, EMBASE, Cochrane Central Register of Controlled Trials, and clinicaltrials.gov were assessed.Selection criteria Cross-sectional and randomised studies that assessed fetal acidosis (using lactate as the index test) with or without an assessment of neonatal outcome.Data collection and analysis Correlations between index and reference test(s) were recorded, as were the raw data to classify the predictive ability of umbilical lactate for neonatal outcomes. Metaanalysis of correlation was performed. We plotted estimates of the studies' observed sensitivities and specificities on Forest plots with 95% confidence intervals (CI). Where possible, we combined data using meta-analysis, applying the hierarchical summary receiver operating characteristics model and a bivariate model.Main results Twelve studies were included. Umbilical lactate correlated with pH [pooled effect size (ES) À0.650; 95% CI À0.663 to À0.637, P < 0.001], base excess (ES À0.710; 95% CI À0.721 to À0.699, P < 0.001), and Apgar scores at 5 minutes (ES 0.300; 95% 0.193-0.407, P < 0.001). Umbilical lactate had pooled sensitivity and specificity for predicting neonatal neurological outcome including hypoxic ischaemic encephalopathy of 69.7% (95% CI 23.8-94.4%) and 93% (95% CI 86.8-96.3%).Authors' conclusion Umbilical cord lactate is a clinically applicable, inexpensive and effective way to measure acidosis and is a tool that may be used in the assessment of neonatal outcome.

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Section: Discussionmentioning

confidence: 99%

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

Allanson

Waqar

White

et al. 2016

BJOG

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“…Previous studies [23][24][25][26] have shown promising results. However, some of the previous studies were undertaken in circumstances that did not adequately represent real labor ward conditions for analyzing fetal scalp blood samples.…”

Section: Discussionmentioning

confidence: 90%

Validation of a point-of-care (POC) lactate testing device for fetal scalp blood sampling during labor: clinical considerations, practicalities and realities

Reif

Lakovschek

Tappauf

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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A POC device which allows for a calibration adjustment to be made following preclinical testing can provide results that will correlate closely to an incumbent lactate method such as a blood gas analyzer. The use of a POC lactate device can address the impracticality and reality of pH sample collection and testing failures experienced in day to day clinical practice. For the StatStrip Lactate meter we suggest using a lactate cut-off of 5.1 mmol/L for predicting fetal acidosis (pH<7.20).

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“…The monitor results have been shown to correlate well with standard laboratory measurements in humans and animals using enzymatic colorimetric and blood gas analyzers as the gold standard. The Lactate Pro has also been tested at altitudes up to 6,000 meters and À21 C and was found to produce reliable results (19)(20)(21)(22).…”

Section: Operational Definitions Of Variables and Protocolmentioning

confidence: 98%

Early Detection and Treatment of Patients with Severe Sepsis by Prehospital Personnel

Guerra

Mayfield

Meyers

et al. 2013

The Journal of Emergency Medicine

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Comparison and validation of point of care lactate meters as a replacement for fetal pH measurement

Cited by 29 publications

References 10 publications

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

Validation of a point-of-care (POC) lactate testing device for fetal scalp blood sampling during labor: clinical considerations, practicalities and realities

Early Detection and Treatment of Patients with Severe Sepsis by Prehospital Personnel

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