Comparison and evaluation of lupus nephritis response criteria in lupus activity indices and clinical trials

Corapi, Kristin M.; Dooley, Mary Anne; Pendergraft, William F.

doi:10.1186/s13075-015-0621-6

Cited by 37 publications

(31 citation statements)

References 50 publications

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“…Even though some authors suggest using the PCR, Houssiau et al, highlighted the importance of a 24H-P for proteinuria measurement as part of a complete initial evaluation of the patient with SLE and possible LN [21]. Moreover, Corapi et al, emphasized that PCR may lack accuracy for the quantification of proteinuria in LN compared to other glomerulopathies [22], thus the evidence favors 24H-P.…”

Section: Proteinuria In Lupus As a Marker Of Kidney Involvementmentioning

confidence: 99%

“…A recent meta-analysis highlighted the methodological flaws of studies on the validity of PCR as a quantitative test for proteinuria and recommended the use of 24H-P for accurate proteinuria measurement [81]. In addition, Corapi et al, also recommended the use of 24H-P instead of PCR in clinical research and drug trials [22].…”

Section: How To Accurately Measure Proteinuria In Lupusmentioning

confidence: 99%

“…Proteinuria is routinely assessed in clinical practice and abnormal results develop earlier than the deterioration in estimated Glomerular Filtration Rate (GFR), making it more suitable for evaluating kidney function and activity in SLE [22]. Proteinuria has a better diagnostic accuracy than other classical biomarkers such as the urinary sediments (pyuria, hematuria and casts).…”

Section: Proteinuria In Lupus As a Marker Of Disease Activitymentioning

confidence: 99%

“…These findings confirm the validity of PCR as a screening test for proteinuria in LN, but there is still a lack of agreement on the best test to accurately quantify proteinuria (24H-P vs PCR). Recently, the evidence favoured 24H-P over PCR because of the accuracy of the results [22,80,81]. A recent meta-analysis highlighted the methodological flaws of studies on the validity of PCR as a quantitative test for proteinuria and recommended the use of 24H-P for accurate proteinuria measurement [81].…”

Section: How To Accurately Measure Proteinuria In Lupusmentioning

confidence: 99%

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A Brief Comment On The Treatment Of Internal Hemorrhoids By Rubber Band Ligation Combined With Sclerotherapy

Zhixian¹

2019

AVS

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Section: Proteinuria In Lupus As a Marker Of Kidney Involvementmentioning

confidence: 99%

Section: How To Accurately Measure Proteinuria In Lupusmentioning

confidence: 99%

Section: Proteinuria In Lupus As a Marker Of Disease Activitymentioning

confidence: 99%

Section: How To Accurately Measure Proteinuria In Lupusmentioning

confidence: 99%

See 2 more Smart Citations

A Brief Comment On The Treatment Of Internal Hemorrhoids By Rubber Band Ligation Combined With Sclerotherapy

Zhixian¹

2019

AVS

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“…Lupus nephritis (LN) is one of the most serious complications of SLE since it is associated with significant morbidity and mortality. In the United States, approximately 35% of adults with SLE have clinical evidence of nephritis at the time of diagnosis; with an estimated total of 50 to 60% developing nephritis during the first 10 years of disease (Lee et al, 2010;Hahn et al, 2012;Corapi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Renal arterial resistive index in Egyptian patients with lupus nephritis: Correlation with disease activity and biopsy parameters

El-Wakil¹,

Khalil²,

Maharem³

et al. 2018

Int Res J Med Med Sci

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Lupus nephritis (LN) affects up to 60% of patients with systemic lupus erythematosus (SLE), either as the initial manifestation or during the disease course. Moreover, LN has a negative impact on survival of SLE patients. Accordingly, it is mandatory to identify specific and feasible markers able to guide clinicians towards the adequate therapeutic option in LN patients. The aim of this work was to evaluate the predictive value of renal resistance index (RRI), measured by Doppler Sonography in comparison with disease activity score, serologic and biopsy parameters in patients with LN. This study was carried out on forty three SLE patients, they were categorized into two groups: Group I included thirty three patients with LN and Group II included ten patients without LN and Group III included ten healthy subjects of matched age and sex as control group. All were subjected to history taking, clinical examination, assessment of disease activity by SLEDAI, laboratory investigations including FBG, blood urea, serum creatinine, serum albumin, CBC, ESR, CRP, complete urine analysis, 24 hour urine protein, eGFR, serum ANA, anti ds-DNA titre, C3, C4 and renal Doppler with measurement of RRI. Renal biopsy was done for those with LN. The mean value of RRI was statistically significantly higher in group I than that of group II and group III. Out of 33 cases of LN cases, 6 patients had RRI of 0.7 and above giving a percentage of 18.18%. LN patients with RRI higher than 0.7 had statistically significant higher age, mean serum creatinine and blood urea levels and a lower eGFR, higher chronicity index of renal biopsy. RRI is of clinical significance in predicting the chronicity index of renal biopsy which is a major determinant of renal outcome so it is useful as non invasive technique to evaluate chronicity in patients with LN, therefore justifying aggressive immune suppression but further follow-up studies are needed to evaluate its role in predicting response to treatment.

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Urine biomarker score captures response to induction therapy with lupus nephritis

et al. 2023

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Background The Renal Activity Index for Lupus (RAIL) consists of urine protein assessment of neutrophil gelatinase–associated lipocalin, kidney injury molecule-1, monocyte chemotactic protein 1, adiponectin, hemopexin, and ceruloplasmin, which non-invasively identifies lupus nephritis (LN). We aimed to delineate RAIL scores with inactive versus active LN and changes over time with response to LN induction therapy. Methods There were 128 pediatric patients with systemic lupus erythematosus (SLE) and age-matched healthy controls recruited in a prospective case control study, with kidney biopsy confirmation of LN. Laboratory and clinical information was recorded and urine collected at diagnosis and end of induction and during maintenance therapy. Response to therapy was assessed by repeat kidney biopsy or laboratory parameters. Urine was assayed for RAIL biomarkers and the RAIL score calculated. Results Pediatric RAIL (pRAIL) scores from 128 children and young adults with SLE (with/without LN: 70/38) including 25 during LN induction therapy, differentiated clinically active LN from inactive LN or without LN, and controls (all p < 0.0017). pRAIL scores significantly decreased with complete LN remission by 1.07 ± 1.7 (p = 0.03). Conclusions The RAIL biomarkers differentiate LN patients based on activity of kidney disease, with decreases of ≥ 1 in pRAIL scores indicating complete response to induction therapy. Significantly lower RAIL scores in healthy controls and in SLE patients without known LN raise the possibility of subclinical kidney disease. Graphical abstract

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Comparison and evaluation of lupus nephritis response criteria in lupus activity indices and clinical trials

Cited by 37 publications

References 50 publications

A Brief Comment On The Treatment Of Internal Hemorrhoids By Rubber Band Ligation Combined With Sclerotherapy

A Brief Comment On The Treatment Of Internal Hemorrhoids By Rubber Band Ligation Combined With Sclerotherapy

Renal arterial resistive index in Egyptian patients with lupus nephritis: Correlation with disease activity and biopsy parameters

Urine biomarker score captures response to induction therapy with lupus nephritis

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