Comparison and correlation of in vitro, in vivo and in silico evaluations of alpha, beta and gamma cyclodextrin complexes of curcumin

A 1H NMR Study of Host/Guest Supramolecular Complexes of a Curcumin Analogue with β-Cyclodextrin and a β-Cyclodextrin-Conjugated Gemini Surfactant

“…βCD and its derivatives have been utilized in various studies as carriers for curcumin delivery. [9][10][11][12][13] Recently Jahed et al evaluated the structure of βCD/curcumin inclusion complex by NMR spectroscopy and molecular modeling. 11 They reported that the aromatic rings of curcumin interact with the internal cavity protons of βCD through hydrophobic forces.…”

Remote loading of curcumin-in-modified β-cyclodextrins into liposomes using a transmembrane pH gradient

“…These result are consistent with Jahed et al and Patro et al conclusions of 1 : 1 or 1 : 2 stoichiometry based on phase solubility diagram, NMR results and molecular modelling calculations. 40,41 In addition, 1 : 2 ratio of CRM with hydroxyl propyl derivatives of bCD (HP-bCD) also strongly reported based on NMR studies. 42 Moreover, CRM forms strong 2 : 1 host : guest inclusion complexes with bCD and HP-bCD, according to Baglole et al, without eliminating the occurrence of 1 : 1 stoichiometry as conrmed by the uorescence enhancement titration study of CRM upon complexation with increasing ratios of CDs.…”

Sustaining guest molecules on bio-surfaces by grafting the surfaces with cyclodextrins

“…We, therefore, evaluated the success of grafting through an ability of the ␤-CD-grafted hair to retain curcumin. Since curcumin possesses the autofluorescence property and ability to form an inclusion complex with ␤-CD (Patro et al, 2013), the compound was chosen as a model guest molecule to demonstrate the drug retaining property of the ␤-CD-grafted hair.…”