Comparison among different presentations of venous thromboembolism because of lung cancer

Guo, Ji-Ming; Deng, Qinfang; Xiong, Wei; Pudasaini, Bigyan; Yuan, Ping; Zhou, Caicun

doi:10.1111/crj.13060

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…A recent cohort study has shown that 9.23% of patients with lung cancer had a diagnosis of VTE ( 11 ). The incidence of thrombosis is as high as 13.6% throughout non-small cell lung cancer cases ( 11 ) and the lung adenocarcinoma accounts three-fold higher than squamous cell carcinoma, which may be attributed to increased mucin ( 12 ). The pathogenesis of cancer-associated thrombosis is multifactorial and involves all aspects of Virchow’s triad.…”

Section: Discussionmentioning

confidence: 99%

Case Report: A Mysterious Giant Thrombus in the Right Atrium in a Patient With Dilated Cardiomyopathy

Lian

Xia

Zhu

et al. 2022

Front. Cardiovasc. Med.

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An isolated right atrial thrombus is a life-threatening entity that is extremely rare in patients with dilated cardiomyopathy (DCM), which is characterized by a reduced left ventricular function and consequent left ventricular thrombosis. Here, we present the case of a mysterious isolated giant right atrial thrombus in a male patient with DCM. The presence of deep vein thrombosis prompted us to investigate for other underlying diseases for his right atrial thrombus. Interestingly, the elevation of two tumor markers indicated the likelihood of cancer-associated thrombosis. Further, the computed tomography demonstrated a spiculated mass in the lower right lung that was confirmed by an endobronchial biopsy as lung squamous cell carcinoma. Consequently, the giant thrombus in the right atrium should be attributed principally to lung squamous cell carcinoma on the background of DCM. After 3 weeks of enoxaparin, the echocardiogram indicated partial resolution of the thrombus. However, the patient suffered sudden death due to pulmonary embolism.

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Section: Discussionmentioning

confidence: 99%

Case Report: A Mysterious Giant Thrombus in the Right Atrium in a Patient With Dilated Cardiomyopathy

Lian

Xia

Zhu

et al. 2022

Front. Cardiovasc. Med.

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“…The Khorana score is the most classic, authoritative, and long-tested VTE risk assessment score, in which a total score > 2 represents a high risk of VTE [ 11 ]. Lung cancer patients with metastatic disease status are nearly 3 times likely to develop VTE, in contrast to those with non-metastatic status [ 23 , 24 ]. In a study with respect to venous thrombosis in resected specimens for non-small cell lung cancer (NSCLC), 53.6% of cases with thrombosis were accompanied by tumor vascular infiltrating [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer

Xiong

Zhao

et al. 2021

Thrombosis J

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Background Cancer-associated venous thromboembolism (VTE) is common in patients with primary lung cancer. It has been understudied which authoritative risk assessment score of cancer-associated VTE is optimal for the assessment of VTE development in hospitalized medical patients with lung cancer. Methods Patients with lung cancer who had undergone computed tomography pulmonary angiography (CTPA), compression ultrasonography (CUS) of lower and upper extremities, and/or planar ventilation/perfusion (V/Q) scan to confirm the presence or absence of VTE during a medical hospitalization were retrospectively reviewed. Based on the actual prevalence of VTE among all patients, the possibility of VTE were reassessed with the Khorana score, the PROTECHT score, the CONKO score, the ONKOTEV score, the COMPASS-CAT score, and the CATS/MICA score, to compare their assessment accuracy for VTE development. Results A total of 1263 patients with lung cancer were incorporated into the final analysis. With respect to assessment efficiency for VTE occurrence, the scores with adjusted agreement from highest to lowest were the ONKOTEV score (78.6%), the PROTECHT score (73.4%), the CONKO score (72.1%), the COMPASS-CAT score (71.7%), the Khorana score (70.9%), and the CATS/MICA score (60.3%). The ONKOTEV score had the highest Youden index which was 0.68, followed by the PROTECHT score (0.58), the COMPASS-CAT score (0.56), the CONKO score (0.55), the Khorana score (0.53), and the CATS/MICA score (0.23). Conclusions Among the Khorana score, the PROTECHT score, the CONKO score, the ONKOTEV score, the COMPASS-CAT score, and the CATS/MICA score which are approved by authoritative guidelines, the ONKOTEV score is optimal for the assessment of VTE development in hospitalized medical patients with lung cancer.

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“…17 Interestingly, elevated CEA levels has been associated with an increased risk for the development of PE. 16,18 Of the histologic variants, lung adenocarcinoma is the lung cancer histopathology most associated with the later development of VTE. 16 Other important risk factors that were associated with increased prevalence of VTE in patients with lung cancer were the presence of distant metastasis, leukocytosis, and younger age.…”

Section: Lung Cancer and Vtementioning

confidence: 99%

Lung Adenocarcinoma Presenting as Multiple Thromboembolic Events: A Case Report and Review of the Literature

Fortuna

Singh

Jacobs

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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Patients with malignancy may present with significant thromboembolic complications including deep vein thrombosis (DVT), pulmonary embolism, arterial thrombosis, nonbacterial thrombotic endocarditis, and stroke due to abnormal coagulation cascades. Although these events are typically recognized later in the disease process, complications of a hypercoagulable state can rarely present as the first manifestation of an occult malignancy. We report a case of a young male who was ultimately found to have an aggressive form of lung adenocarcinoma after the initial presentation of multiple thromboembolic events. DVT and stroke as an initial presentation of an active lung adenocarcinoma in a young patient is extremely rare as patients presenting in a hypercoagulable state usually are older. Though testing for a hypercoagulable state is not recommended for the first unprovoked DVT, clinicians should be prompted to screen for malignancy in the setting of cryptogenic strokes, especially in younger patients with no prior risk factors.

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Comparison among different presentations of venous thromboembolism because of lung cancer

Cited by 7 publications

References 20 publications

Case Report: A Mysterious Giant Thrombus in the Right Atrium in a Patient With Dilated Cardiomyopathy

Case Report: A Mysterious Giant Thrombus in the Right Atrium in a Patient With Dilated Cardiomyopathy

Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer

Lung Adenocarcinoma Presenting as Multiple Thromboembolic Events: A Case Report and Review of the Literature

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