Comparison among different available surgical approaches in T1 glottic cancer

Karatzanis, Alexander D.; Psychogios, Georgios; Zenk, Johannes; Waldfahrer, Frank; Hornung, Joachim; Velegrakis, George A.; Iro, Heinrich

doi:10.1002/lary.20537

Cited by 55 publications

(45 citation statements)

References 29 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although this resection type is not considered ideal and presents difficulties for histological assessment, studies have demonstrated no sacrifice of oncological control when block-wise resection of the tumour in discrete segments is performed. [9][10][11] It has also been suggested that for a bulky tumour, removing it in sections has the advantage of defining the depth of tumour penetration and delineating the deep margin under high magnification. 12 More than half of our specimens were mounted and orientated for pathological examination and most followed the ENT UK recommendation of using the Glasgow technique of mounting the orientated specimen on dehydrated cucumber.…”

Section: Discussionmentioning

confidence: 99%

Audit of transoral laser-assisted microsurgical resection of early laryngeal cancer

Amir

Vernham

2015

J. Laryngol. Otol.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Audit of transoral laser-assisted microsurgical resection of early laryngeal cancer

Amir

Vernham

2015

J. Laryngol. Otol.

View full text Add to dashboard Cite

show abstract

“…Though radiotherapy is considered the treatment of choice in many European countries, there are a number of recent studies emphasizing the importance of surgery in treatment of early glottic carcinoma [2–4, 11]. Both surgery and radiotherapy provide good locoregional control and satisfactory functional results, so other factors come into consideration when choosing the adequate treatment.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, recurrent malignancy was noted in 7.7% patients in endoscopic laser cordectomy group and in 9.1% in open cordectomy group. Comparing different surgical approaches, Karatzanis et al had 5-year disease-specific survival of 96.5% for T1a cases and no statistically significant differences noted between different types of procedures: cordectomy and transoral laser microsurgery [11]. Motta et al published survival rate of 85% and adjusted survival rate of 97% in 432 T1aN0 M0 patients treated with transoral laser microsurgery.…”

Section: Discussionmentioning

confidence: 99%

Oncological and Functional Outcome after Surgical Treatment of Early Glottic Carcinoma without Anterior Commissure Involvement

Milovanović

Jotić

Djukić

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Introduction. Glottic carcinoma can be successfully diagnosed in its early stages and treated with high percentage of success. Organ preservation and optimal functional outcomes could be achieved with wide array of surgical techniques for early glottic cancer, including endoscopic approaches or open laryngeal preserving procedures, making surgery the preferred method of treatment of early glottic carcinoma in the last few years. Material and Methods. Prospective study was done on 59 patients treated for Tis and T1a glottic carcinoma over a one-year time period in a tertiary medical center. Patients were treated with endoscopic laser cordectomy (types II–IV cordectomies according to European Laryngological Society classification of endoscopic cordectomies) and open cordectomy through laryngofissure. Follow-up period was 60 months. Clinical and oncological results were followed postoperatively. Voice quality after the treatment was assessed using multidimensional voice analysis 12 months after the treatment. Results. There were no significant differences between oncological and functional results among two groups of patients, though complications were more frequent in patients treated with open cordectomy. Conclusion. Endoscopic laser surgery should be the first treatment of choice in treatment of early glottic carcinomas, though open approach through laryngofissure should be available for selected cases where anatomical factors present limiting adequate tumor removal.

show abstract

“…Despite advances in the development of conventional therapies such as surgery, radiotherapy and chemotherapy, the 5-year survival rate for patients with LSCC remains unsatisfactory (~50-70%) (2). Locoregional recurrences, lymph node and distant metastasis are major causes of death that significantly affect prognosis in LSCC patients (3).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Tiam1 promotes the progression of laryngeal squamous cell carcinoma

Wang

Tang

et al. 2015

Oncology Reports

View full text Add to dashboard Cite

Abstract. T-lymphoma invasion and metastasis-inducing factor 1 (Tiam1) has been reported in various types of human cancer, which play important roles in facilitating the metastasis of malignant tumor. However, the investigation of Tiam1 in laryngeal squamous-cell carcinoma is extremely rare. The aim of the present study was to assess Tiam1 expression and examine its function in tumorigenesis and the metastasis of laryngeal squamous cell carcinoma (LSCC) in vitro. Tiam1 expression in 98 primary LSCC tissue specimens was analyzed by immunohistochemistry and correlated with clinicopathological parameters and patients' survival. To investigate the effects of Tiam1 on the progression of LSCC, Tiam1/C1199 plasmid was transfected into LSCC, and proliferation, apoptosis, migration and invasion of transfected cells were examined using MTT, flow cytometry, wound-healing and Transwell assay, respectively. The results showed that, Tiam1 was detected in all primary LSCC samples. Additionally, Tiam1 overexpression was closely correlated with tumor progression and patient survival. Tiam1 overexpression was statistically significant, and served as an independent predictor of prognosis for patients with LSCC. The upregulation of Tiam1 by Tiam1/C1199 plasmid had no effect on the proliferation of transfected cells, but decreased the apoptotic rate of transfected cells, while the ability of migration and invasion was increased. These results suggested that Tiam1 overexpression in LSCC is possibly involved in the promotion of migration and invasion, and is a promising therapeutic target in the prevention of the progression of LSCC.

show abstract

Comparison among different available surgical approaches in T1 glottic cancer

Cited by 55 publications

References 29 publications

Audit of transoral laser-assisted microsurgical resection of early laryngeal cancer

Audit of transoral laser-assisted microsurgical resection of early laryngeal cancer

Oncological and Functional Outcome after Surgical Treatment of Early Glottic Carcinoma without Anterior Commissure Involvement

Overexpression of Tiam1 promotes the progression of laryngeal squamous cell carcinoma

Contact Info

Product

Resources

About