Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor

Decker, Brennan; Davis, Brian W.; Rimbault, Maud; Long, Adrienne H.; Karlins, Eric; Jagannathan, Vidhya; Reiman, Rebecca; Parker, Heidi G.; Drögemüller, Cord; Corneveaux, Jason J.; Chapman, Erica S.; Trent, Jeffery M.; Leeb, Tosso; Huentelman, Matthew J.; Wayne, Robert K.; Karyadi, Danielle M.; Ostrander, Elaine A.

doi:10.1101/gr.190314.115

Cited by 65 publications

(92 citation statements)

References 45 publications

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“…Given that DFTD is likely infectious due to immune system evasion via improper expression of its own MHC, as well as downregulation of MHC expression in the devil host10, the functions of these genes suggest that the devil immune system may be adapting to be able to recognize tumour cells. Five of the candidate genes are consistent with those that manipulate host immunity by CTVT21. Thus, although the Tasmanian devil and dog tumours are independently evolved, features that circumvent the host immune system in both tumours appear necessary for evolution of cancer transmissibility.…”

Section: Discussionmentioning

confidence: 69%

Rapid evolutionary response to a transmissible cancer in Tasmanian devils

et al. 2016

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Although cancer rarely acts as an infectious disease, a recently emerged transmissible cancer in Tasmanian devils (Sarcophilus harrisii) is virtually 100% fatal. Devil facial tumour disease (DFTD) has swept across nearly the entire species' range, resulting in localized declines exceeding 90% and an overall species decline of more than 80% in less than 20 years. Despite epidemiological models that predict extinction, populations in long-diseased sites persist. Here we report rare genomic evidence of a rapid, parallel evolutionary response to strong selection imposed by a wildlife disease. We identify two genomic regions that contain genes related to immune function or cancer risk in humans that exhibit concordant signatures of selection across three populations. DFTD spreads between hosts by suppressing and evading the immune system, and our results suggest that hosts are evolving immune-modulated resistance that could aid in species persistence in the face of this devastating disease.

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Section: Discussionmentioning

confidence: 69%

Rapid evolutionary response to a transmissible cancer in Tasmanian devils

et al. 2016

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“…We next sequenced the entire genome of a single hairless AHT using protocols we described previously [47]. The vcftools command vcf-contrast [48] was used to identify genotypes found in the AHT that were not found in 89 other dogs with whole genome sequence data.…”

Section: Hairless Dogsmentioning

confidence: 99%

The bald and the beautiful: hairlessness in domestic dog breeds

Parker¹,

Harris²,

Dreger³

et al. 2017

Phil. Trans. R. Soc. B

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An extraordinary amount of genomic variation is contained within the chromosomes of domestic dogs, manifesting as dramatic differences in morphology, behaviour and disease susceptibility. Morphology, in particular, has been a topic of enormous interest as biologists struggle to understand the small window of dog domestication from wolves, and the division of dogs into pure breeding, closed populations termed breeds. Many traits related to morphology, including body size, leg length and skull shape, have been under selection as part of the standard descriptions for the nearly 400 breeds recognized worldwide. Just as important, however, are the minor traits that have undergone selection by fanciers and breeders to define dogs of a particular appearance, such as tail length, ear position, back arch and variation in fur (pelage) growth patterns. In this paper, we both review and present new data for traits associated with pelage including fur length, curl, growth, shedding and even the presence or absence of fur. Finally, we report the discovery of a new gene associated with the absence of coat in the American Hairless Terrier breed.This article is part of the themed issue ‘Evo-devo in the genomics era, and the origins of morphological diversity’.

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“…Decker et al (2015) criaram o maior catálogo existente de variação genética canina e compararam este, a amostras tumorais de TVTC, isolando as mudanças somáticas dos tumores da variação genética presente no genoma do câncer fundador, o qual foi previamente reconstituído. O estudo revelou mutações somáticas críticas e precoces que provavelmente contribuíram para o aumento da transmissibilidade clonal.…”

Section: Transmissibilidade Do Tumor Venéreo Transmissível Canino (Tvtc)unclassified

Canine transmissible venereal tumor. The oldest clonal lineage known in nature

Regiani¹,

Vasconcellos²

2018

Pubvet

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RESUMO A técnica de sequenciamento gênico, utilizada no estudo da origem clonal do tumor venéreo transmissível canino (TVTC), abriu novas possibilidades de sondar vulnerabilidades genéticas do câncer, e relações hospedeiro-tumor. De modo análogo, à evolução darwiniana, as células tumorais com maior potencial adaptativo apresentam uma vantagem seletiva em relação às células menos aptas. Desse modo, o câncer transmissível de ocorrência natural, representa um modelo ideal para a investigação evolutiva entre as células cancerosas em seu microambiente tumoral, e o macroambiente circundante. Com objetivo de discutir o impacto das recentes descobertas neste campo, realizou-se uma análise das publicações indexadas na base de dados PubMed ® (Instituto Nacional de Saúde Americano, National Institutes of Health), utilizando os descritores na língua inglesa: canine transmissible venereal tumor, canine transmissible venereal, canine transmissible. Estudos genômicos demonstraram que a linhagem clonal do TVTC é a mais antiga linhagem tumoral conhecida (cerca de 11.000 anos), sendo transmissível por transferência alogênica. Aspectos singulares como evasão ao sistema imune do hospedeiro, também foram revisados. Palavras chave: cães, câncer, epidemiologia Canine transmissible venereal tumor. The oldest clonal lineage known in natureABSTRACT The gene sequencing technique, used in the study of the clonal origin of canine venereal transmissible tumor (CTVT), opened up new possibilities of probing genetic vulnerabilities of cancer, and host-tumor relations. Analogous to Darwinian evolution, tumor cells with higher adaptive potential present a selective advantage over less apt cells, and thus, naturally occurring transmissible cancer, represents an ideal model for the evolutionary investigation between cancer cells in their Microenvironment, and the surrounding macroenvironment. In order to discuss the impact of the recent findings in this field, an analysis of publications indexed in the PubMed ® database (National Institutes of Health) using the English descriptors: venereal canine transmissible Tumor, transmissible venereal canine, transmissible canine. Genomic studies have shown that the clonal lineage of the CTVT is the oldest known tumor line (about 11,000 years old), and can be transmitted by allogeneic transfer. Unique aspects such as evasion to the host immune system were also reviewed.

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Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor

Cited by 65 publications

References 45 publications

Rapid evolutionary response to a transmissible cancer in Tasmanian devils

Rapid evolutionary response to a transmissible cancer in Tasmanian devils

The bald and the beautiful: hairlessness in domestic dog breeds

Canine transmissible venereal tumor. The oldest clonal lineage known in nature

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