Comparision of vital surgical parameters, after administration of midazolam and dexmedetomidine for conscious sedation in minor oral surgery

Abstract

Aim:The aim of this study is to compare the efficacy between midazolam and dexmedetomidine in relation to vital parameters, sedation score, pain score, cognitive judgment, and postoperative amnesia to the event in conscious sedation for minor oral surgical procedure.Materials and Methods:A sample size of 30 patients were selected in each group: Group M (midazolam) and Group D (dexmedetomidine).Results:The mean heart rate (HR) and systolic and diastolic blood pressure measurements were significantly higher in Group M after the 20th min when compared to Group D. The visual analog scale (VAS) scores of pain were not statistically significant between the two groups during the procedure, but at the time of discharge, statistically significant VAS scores were found between the two groups. Nine (30%) patients in Group D and 21 (70%) patients in Group M showed cognitive judgment impairment with the Stroop Color and Word Test at the 30th min.Conclusion:The dexmedetomidine group of patients had reduced blood pressure and HR. No significant differences were noted in oxygen saturation or in respiratory rate between the two drugs. Patients had better sedation, analgesia, lesser cognitive impairment, and amnesia in the dexmedetomidine group.

The influence of drugs used for sedation during mechanical ventilation on respiratory pattern during unassisted breathing and assisted mechanical ventilation: a physiological systematic review and meta-analysis

“…Opioids were associated with a statistically significant mean reduction in respiratory rate of 18% (95% CI 12–24%, p < 0.0001, 24 arms), 15 , 20 , 21 , 33 , 35 , 39 , 46 , 51 , 55 , 56 , 61 , 62 , 65 whereas inhaled sevoflurane was associated with an increase in respiratory rate of 83% (95% CI 49–118%, p < 0.0001, 1 arm). 28 Mean percent changes in respiratory rate were close to zero and not statistically significant with exposure to benzodiazepines (2% decrease, 95% CI 9% decrease-6% increase, 16 arms), 19 , 26 , 27 , 29 , 37 , 42 , 43 , 47 , 50 , 59 , 63 , 64 other hypnotic agents (2% decrease, 95% CI 9% decrease-5% increase, 17 arms), 17 , 23 , 26 , 29 , 30 , 31 , 32 , 34 , 36 , 41 , 44 , 48 , 49 , 59 and propofol (4% increase, 6% decrease-14% increase, 9 arms) 16 , 17 , 30 , 41 , 52 , 54 , 60 , 61 , 63 ( Fig. 2 ).…”

Prophecy with Dexmetomitidine will Decrease the Incidence of Pre-Operative Shivering and Enhance Anti-Shivering-Effect of Tramadol during Cesarean Section

“…However, data in this trial showed that the anti-shivering effect Tramadol was enhanced by Dexmetedomidine. Data in this trial showed a significantly lower ANS in the patient who treated with Dexmetedomidine, which implied that the advantage of Dexmedetomidine preoperative administering [18,19]. Intraoperative shivering in the cesarean section under spinal anesthesia is one of the most frequent surgical procedures in current clinical practices [9,20,21].…”

Analgesia-based Sedation for Oral Surgery in Patients With Chronic Respiratory Obstructive Disease

“…14 In addition, relatively invasive oral surgery can be performed safely in conscious sedation. 15 We considered that these cases should be managed under conscious sedation with sufficient analgesia although oral surgeons requested general anesthesia management in both cases.…”

“…During conscious sedation, the reduction or abolition of physiological and psychological responses of the patient to surgery are obtained without a loss of consciousness, collaboration, and protective reflexes 14. In addition, relatively invasive oral surgery can be performed safely in conscious sedation 15. We considered that these cases should be managed under conscious sedation with sufficient analgesia although oral surgeons requested general anesthesia management in both cases.…”