Comparision of Nebulised Salbutamol and L-epinephrine in First Time Wheezy Children

Abstract

Background: Salbutamol is the standard recommendation in bronchial asthma. However, the use of bronchodilators in wheeze associated respiratory infections including bronchiolitis continues to be controversial. The aim of this study was to compare the efficacy of nebulised salbutamol versus epinephrine in 'first time' wheezy children using clinical parameters and airway resistance. Methods: Sixty children between two months to 60 months were recruited, 30 in each treatment group. Children received periodic (0, 20, 40 minutes) doses of either salbutamol (0.15mg/kg with 3ml saline subject to a minimum of 2.5mg) or laevo-epinephrine (1:1000, 0.5ml/kg subject to a max of 2.5ml with 3ml saline) via nebuliser along with oxygen. Changes in heart rate (HR), oxygen saturation (SpO 2 ), respiratory rate (RR) and respiratory distress assessment instrument (RDAI) were assessed along with measurement of airway resistance using interrupter method (Hand held spirometer-Microloop with MicroRint module). Result: The respiratory status was better in the epinephrine group with significant improvement in RR, RDAI score, SpO 2 and fall of airway resistance. There were no significant side effects noted in either group. Conclusion: Nebulised epinephrine is a useful and safe drug for wheezy children and is superior to salbutamol. This needs validation by large multicentric randomized blinded studies. MJAFI 2010; 66 : 9-13

Development of oral dispersible tablets containing prednisolone nanoparticles for the management of pediatric asthma

“…Variables and their two levels are presented in Table 2 . The 2 3 full factorial design is used to optimize the formulation variables with basic requirement of understanding interaction of independent variables. Linear, cross-product contribution (2FI), quadratic, and cubic models were generated for the responses.…”

“… 1 Asthma may also be classified as atopic (extrinsic) or nonatopic (intrinsic), where atopy refers to a predisposition toward developing type 1 hypersensitivity reactions. 2 , 3 Asthma is the clinical condition that may occur in adult and pediatric patients. For some children with asthma, their first asthmatic experience can be frightening – heavy wheezing, a tight chest, and shortness of breath can quickly catch their active, young bodies off-guard.…”

Is Iron Deficiency Anaemia, a risk Factor For Wheeze Associated Respiratory Tract Infection in Children?

“…P opula on studies have shown that approximately one in three children has at least one episode of wheezing prior to their third birthday, and the cumula ve prevalence of wheeze is almost 50% at the age of six years 1 . Despite its high prevalence, there is a lack of evidence regarding the pathophysiology and treatment of fi rst episode of wheeze 1 .…”

“…Despite its high prevalence, there is a lack of evidence regarding the pathophysiology and treatment of fi rst episode of wheeze 1 . WHO es mates that in 2001, iron defi ciency anaemia (IDA) resulted in 273,000 deaths: 45% in Southeast Asia.…”