Comparision of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response – A randomized controlled trial

Kakkar, Aanchal; Tyagi, Asha; Nabi, Nazish; Sethi, Ankur; Verma, Uttam

doi:10.1016/j.jclinane.2016.04.026

Cited by 20 publications

(12 citation statements)

References 24 publications

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“…Pregabalin binds to α 2 δ subunit of voltage sensitive calcium channels and enhance the release of neurotransmitters at the synapses of primary afferent fibers and second-order sensory neurons (7) . It is cost effective and can be administered orally with peak plasma levels reached within an average interval of 54 minutes (8) . Hence, we compared the benefits of pregabalin with another proven drug, the dexmedetomidine which is also effective in suppressing the sympathoadrenal response during intubation.…”

Section: Discussionmentioning

confidence: 99%

“…Kakkar et al (8) compared 1 µg kg -1 clonidine, 1 µg kg -1 , and 0.5 µg kg -1 dexmedetomidine for attenuation of hemodynamic response to endotracheal intubation and found that all groups were effective in attenuating hemodynamic response. It was found that 1 µg kg -1 dexmedetomidine group had higher incidence of hypotension than other two groups but in our study administration of 1 µg kg -1 dexmedetomidine did not produce any significant hypotension.…”

Section: Discussionmentioning

confidence: 99%

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Attenuation of Hemodynamic Response to Tracheal Intubation with Pregabalin and Dexmedetomidine - A Prospective Randomized Double Blinded Study

Sambandam¹,

Chandrasekran²,

Dhanasekaran³

et al. 2020

jarss

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Objective: Airway manipulation during endotracheal intubation is a potential stimulus and it is associated with untoward hemodynamic changes. The aim of this study was to compare the efficacy of intravenous dexmedetomidine and oral pregabalin premedication for attenuation of hemodynamic pressor response to laryngoscopy and intubation. Methods: A total of 60 patients of age group of 18-60 years scheduled for elective surgeries under general anesthesia with ASA physical status I were randomized into two groups. Group D received intravenous dexmedetomidine at a dose of 1 µg kg-1 over 10 minutes before induction and group P received oral pregabalin 150 mg one hour prior to intubation. The primary outcomes, heart rate and mean arterial pressure noted at serial intervals during intubation were compared between the groups. Sedation score was assessed as secondary outcome using Richmond Agitation Sedation Scale Scores (RAAS). Results: Group D and P were comparable with distribution of age, sex and duration of laryngoscopy. The mean heart rates and mean arterial pressures assessed at serial measurements at 0, 1, 3, 5, 10 minutes post-intubation were statistically significant (p=0.005) in dexmedetomidine group when compared to pregabalin group. The RASS scores assessed at 15, 30 and 60 minutes post-extubation were statistically significant (p<0.05) in pregabalin group when compared to dexmedetomidine group. Conclusion: Intravenous dexmedetomidine at a dose of 1 µg kg-1 is more effective than oral pregabalin 150 mg in attenuating hemodynamic response to laryngoscopy and orotracheal intubation. Post-procedural sedation was better achieved with oral pregabalin compared to intravenous dexmedetomidine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Attenuation of Hemodynamic Response to Tracheal Intubation with Pregabalin and Dexmedetomidine - A Prospective Randomized Double Blinded Study

Sambandam¹,

Chandrasekran²,

Dhanasekaran³

et al. 2020

jarss

View full text Add to dashboard Cite

show abstract

“…demonstrated that both clonidine and dexmedetomidine were effective for preventing hemodynamic response to intubation, but dexmedetomidine was associated with more side effects such as hypotension and bradycardia. [ 25 ] In our study, two patients also developed bradycardia which were excluded. The HR was also lower from baseline after drug administration in dexmedetomidine group than clonidine.…”

Section: Discussionmentioning

confidence: 99%

Evaluation and comparison of clonidine and dexmedetomidine for attenuation of hemodynamic response to laryngoscopy and intubation: A randomized controlled study

Hussain

Karmarkar²,

Jain

2018

Anesth Essays Res

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“…A variety of sedatives, such as propofol combined with midazolam, are commonly used in induction of anesthesia. Dexmedetomidine (DEX) is now commonly used in anesthesia induction because of its sympatholytic effect and it can attenuate the cardiovascular response during intubation [1,2]. However, there is still a lack of clinical experience in the combined use of these two drugs in the induction of anesthesia, and sedative overdose may occur during induction of anesthesia.…”

Section: Introductionmentioning

confidence: 99%

The effects of different doses of dexmedetomidine on the requirements for propofol for loss of consciousness in patients monitored via the bispectral index: a double-blind, placebo-controlled trial

Yang

Zheng

et al. 2020

BMC Anesthesiol

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Background: The α 2-adrenergic agonist dexmedetomidine (DEX) is a sedative and can be used as an adjunct to hypnotics. The study sought to evaluate the effects of different doses of DEX on the requirements for propofol for loss of consciousness (LOC) in patients monitored via the bispectral index (BIS). Methods: In this randomized, double-blind, three arm parallel group design and placebo-controlled trial, 73 patients aged between 18 and~65 years with a BMI range of 18.0-24.5 kg•m − 2 and an American Society of Anesthesiologists (ASA) grade I or II who were scheduled for general anesthesia at the General Hospital of Ningxia Medical University were included in this study. Anesthesiologists and patients were blinded to the syringe contents. All patients were randomly assigned in a 1:1:1 ratio to receive a 0.5 μg•kg − 1 DEX infusion (0.5 μg•kg − 1 DEX group; n = 24), a 1.0 μg•kg − 1 DEX infusion (1.0 μg•kg − 1 DEX group; n = 25) or a saline infusion (control group; n = 24) for 10 min. Propofol at a concentration of 20 mg•kg − 1 •h − 1 was then infused at the end of the DEX or saline infusion. The propofol infusion was stopped when the patient being infused lost consciousness. The primary endpoint were propofol requirements for LOC and BIS value at LOC.

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Comparision of clonidine and dexmedetomidine for attenuation of laryngoscopy and intubation response – A randomized controlled trial

Cited by 20 publications

References 24 publications

Attenuation of Hemodynamic Response to Tracheal Intubation with Pregabalin and Dexmedetomidine - A Prospective Randomized Double Blinded Study

Attenuation of Hemodynamic Response to Tracheal Intubation with Pregabalin and Dexmedetomidine - A Prospective Randomized Double Blinded Study

Evaluation and comparison of clonidine and dexmedetomidine for attenuation of hemodynamic response to laryngoscopy and intubation: A randomized controlled study

The effects of different doses of dexmedetomidine on the requirements for propofol for loss of consciousness in patients monitored via the bispectral index: a double-blind, placebo-controlled trial

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