Comparing treatment effects of oral THC on simulated and on-the-road driving performance: testing the validity of driving simulator drug research

Veldstra, Janet; Bosker, Wendy M.; Waard, Dick de; Ramaekers, Johannes G.; Brookhuis, Karel

doi:10.1007/s00213-015-3927-9

Cited by 45 publications

(45 citation statements)

References 30 publications

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“…Results show that driving stability is impaired after THC intake, both in simulated and real driving conditions. Globally, these results are coherent with the results of previous studies involving simulation or real driving conditions . In Lenné et al.…”

Section: Discussionsupporting

confidence: 90%

“…We selected ILC as our main outcome criterion to quantify driving impairment after THC intake, as several studies showed that accidents related to a diminution of awareness frequently occur after an ILC with a single car driving off the road without reaction from the driver . Other studies evaluating the effects sleepiness, alcohol or benzodiazepine intake on driving performance in simulated and real conditions reported similar results . For example, Philip et al.…”

Section: Discussionmentioning

confidence: 99%

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Cannabis smoking impairs driving performance on the simulator and real driving: a randomized, double‐blind, placebo‐controlled, crossover trial

Micallef

Dupouey

Jouve

et al. 2018

Fundamemntal Clinical Pharma

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Driving experiments in real conditions are considered as a 'gold standard' to evaluate the effects of drugs on driving performance. Several constraints are difficult to manage in these conditions, so driving simulation appears as the best alternative. A preliminary comparison is crucial before being able to use driving simulation as a valid evaluation method. The aim of this study was to design a driving simulation method for assessing drug effects on driving. We used cannabis (THC) as a positive control and assessed whether THC affects driving performance in simulation conditions and whether these effects are consistent with performance in real driving conditions. A double-blind, placebo-controlled, two successive two-way crossover design was performed using cigarettes containing 20 mg of THC. Healthy occasional users of THC, aged 25-35 years, who had a consistent driving experience were included. The first two sessions were realized in simulation conditions, and the last two sessions were in real driving conditions. Driving performance was estimated through inappropriate line crossings (ILC) and the standard deviation of the vehicle's lateral position. Participants felt significantly drowsier and more tired after THC, whatever the driving condition. Driving stability was significantly impaired after THC, both in simulated and real driving conditions. We also found that ILC were significantly more numerous in driving simulation conditions, as compared to real driving. In conclusion, the driving simulator was proven to be more sensitive for demonstrating THC-induced effects on driving performances. Driving simulation appears to be a good qualitative predictor of driving safety after drug intake.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Cannabis smoking impairs driving performance on the simulator and real driving: a randomized, double‐blind, placebo‐controlled, crossover trial

Micallef

Dupouey

Jouve

et al. 2018

Fundamemntal Clinical Pharma

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“…The lane-keeping performance obtained in this study is slightly better than found in real cars, with a standard deviation of lateral position [SDLP] of about 0.10 m, whereas values of 0.15-0.20 m are typically observed in on-road experiments (see Veldstra et al, 2015;Verster and Roth, 2011). This difference may be caused by the narrow road and real-time feedback on performance.…”

Section: Driving Simulator Versus On-road Testscontrasting

confidence: 51%

Does haptic steering guidance instigate speeding? A driving simulator study into causes and remedies

Melman

Winter

Abbink

2017

Accident Analysis & Prevention

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C o v e r i ma g e a d o p t e d f r o m: F o t o k e r e n ( 2 0 1 5 , No v e mb e r ) . Ni g h t h i g h s p e e d c a r f u n [ Di g i t a l i ma g e ] . Re t r i e v e dMa y 2 3 , 2 0 1 6 , f r o m h t t p : / / f o t o k e r e n . n e t / n i g h t -h i g h -s p e e d -c a r -f u n / Driving a car has become a major part of our life. To assist drivers during this task new Advanced Driver Assistance Systems (ADAS) are developed to increase safety and comfort. In reality, however, these safety benefits are often diminished because of adaptations by the driver, such as adopting a higher speed or driving closer to the vehicle in front. In current literature, I found many theories trying to explain why people adapt, but few studies investigating ways to prevent these negative adaptations from occurring (entire literature study is available at http://repository.tudelft.nl/ for more detail). In this MSc. thesis I took the first step from explaining towards preventing behavioral adaptation, with the aim to make novel ADAS more effective in terms of safety.This thesis report is part of the fulfillment for the Master degree of Biomechanical Design at the Delft University of Technology. The driving simulator code, Matlab code used for the data analysis, and statistical analyses have been submitted to the BioMechanical Engineering depository on a USB stick, which is available on request. T. Melman Delft, May 2016iii Acknowledgments First, I would like to thank both my supervisors David Abbink and Joost de Winter for their enthusiasm and support during my MSc. thesis. David always knew how to motivate me, and was there to oversee the bigger picture, whereas Joost, with his keen eye for details, assisted me with tremendous devotion, especially during the last couple of weeks in order to send my thesis to a journal before my graduation. Although we had many memorable discussions, one moment in particular deserves to be mentioned in this acknowledgment; at Sunday evening prior to my experiment, I had some serious concerns. That very same evening, both helped me out, and took these concerns away. Despite the late hour, both were available to help me when I needed them the most. Abstract-An important issue in road traffic safety is that drivers show adverse behavioral adaptation (BA) to driver assistance systems. Haptic steering guidance is an upcoming assistance system which facilitates lane-keeping performance while keeping drivers in the loop, and which may be particularly prone to BA. Thus far, most experiments on haptic steering guidance have measured driver performance while the vehicle speed was kept constant, and so the degree of BA could not be established. The aim of the present driving simulator study was to examine whether haptic steering guidance causes BA in the form of speeding, and to evaluate two types of haptic steering guidance designed not to suffer from BA. Twenty-four participants drove a 1.8 m wide car for 13.9 km on a curved road, with cones demarcating a single 2.2 m narrow lane. Participants comple...

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“…This may also be reflected in reduced motivation to perform the test. Driving simulators also showed to be less sensitive in detecting relative modest drug effects when directly compared to on-road driving [13]. Further, sleepiness scores are usually higher in simulator settings when compared to on-road driving tests [14].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Having a 15-min Break With and Without Consuming an Energy Drink on Prolonged Simulated Highway Driving

et al. 2017

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Comparing treatment effects of oral THC on simulated and on-the-road driving performance: testing the validity of driving simulator drug research

Cited by 45 publications

References 30 publications

Cannabis smoking impairs driving performance on the simulator and real driving: a randomized, double‐blind, placebo‐controlled, crossover trial

Cannabis smoking impairs driving performance on the simulator and real driving: a randomized, double‐blind, placebo‐controlled, crossover trial

Does haptic steering guidance instigate speeding? A driving simulator study into causes and remedies

The Impact of Having a 15-min Break With and Without Consuming an Energy Drink on Prolonged Simulated Highway Driving

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