Comparing the Wada Test and Functional MRI for the Presurgical Evaluation of Memory in Temporal Lobe Epilepsy

Massot‐Tarrús, Andreu; White, Kevin P.; Mirsattari, Seyed M.

doi:10.1007/s11910-019-0945-8

Cited by 23 publications

(11 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, a meta-analysis reported that 44% of left TLE (LTLE) patients faced verbal memory and 34% naming decline ( Sherman et al, 2011 ). Hence, the main goal of preoperative assessment is to perform a cost-benefit analysis and evaluate the risks of cognitive decline versus the potential seizure freedom ( Massot-Tarrús et al, 2019 ). In addition to clinical and neuropsychological characteristics of patients that are essential in the presurgical assessment ( Baxendale et al, 2013 ; Jarčušková et al, 2020 ), functional MRI (fMRI) can predict postoperative cognitive performance and decline, and it is frequently used for preoperative assessment ( Binder et al, 2010 ; Bonelli et al, 2010 ; Sidhu et al, 2015 ; Strandberg et al, 2017 ; You et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Banjac

Roger

Cousin

et al. 2022

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Preoperative mapping of language and declarative memory functions in temporal lobe epilepsy (TLE) patients is essential since they frequently encounter deterioration of these functions and show variable degrees of cerebral reorganization. Due to growing evidence on language and declarative memory interdependence at a neural and neuropsychological level, we propose the GE2REC protocol for interactive language-and-memory network (LMN) mapping. GE2REC consists of three inter-related tasks, sentence generation with implicit encoding (GE) and two recollection (2REC) memory tasks: recognition and recall. This protocol has previously been validated in healthy participants, and in this study, we showed that it also maps the LMN in the left TLE (N = 18). Compared to healthy controls (N = 19), left TLE (LTLE) showed widespread inter- and intra-hemispheric reorganization of the LMN through reduced activity of regions engaged in the integration and the coordination of this meta-network. We also illustrated how this protocol could be implemented in clinical practice individually by presenting two case studies of LTLE patients who underwent efficient surgery and became seizure-free but showed different cognitive outcomes. This protocol can be advantageous for clinical practice because it (a) is short and easy to perform; (b) allows brain mapping of essential cognitive functions, even at an individual level; (c) engages language-and-memory interaction allowing to evaluate the integrative processes within the LMN; (d) provides a more comprehensive assessment by including both verbal and visual modalities, as well as various language and memory processes. Based on the available postsurgical data, we presented preliminary results obtained with this protocol in LTLE patients that could potentially inform the clinical practice. This implies the necessity to further validate the potential of GE2REC for neurosurgical planning, along with two directions, guiding resection and describing LMN neuroplasticity at an individual level.

show abstract

Section: Introductionmentioning

confidence: 99%

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Banjac

Roger

Cousin

et al. 2022

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…TLE patients are often refractory to drugs and surgical removal of the EZ is the only curative option (Schoenberg et al 2011;Téllez-Zenteno et al 2005). Since surgery affects the temporal regions which are crucial for language and memory, the intervention is preceded by detailed preoperative mapping (Baxendale et al 2006;Drane and Pedersen 2019;Hamberger 2015;Helmstaedter et al 2003;Sherman et al 2011) which can be effective in predicting the postoperative decline (Bonelli et al 2010;Massot-Tarrús et al 2019;Rosazza et al 2013). Importantly, it was shown that language fMRI activation can predict verbal memory postoperative outcomes (Binder et al 2008(Binder et al , 2010Labudda et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Interactive mapping of language and memory with the GE2REC protocol

Banjac

Roger

Cousin

et al. 2020

Brain Imaging and Behavior

View full text Add to dashboard Cite

Previous studies have highlighted the importance of considering cognitive functions from a dynamic and interactive perspective and multiple evidence was brought for a language and memory interaction. In this study performed with healthy participants, we present a new protocol entitled GE2REC that interactively accesses the neural representation of language-and-memory network. This protocol consists of three runs related to each other, providing a link between tasks, in order to assure an interactive measure of linguistic and episodic memory processes. GE2REC consists of a sentence generation (GE) in the auditory modality and two recollecting (2REC) memory tasks, one recognition performed in the visual modality, and another one recall performed in the auditory modality. Its efficiency was evaluated in 20 healthy volunteers using a 3T MR imager. Our results corroborate the ability of GE2REC to robustly activate fronto-temporo-parietal language network as well as temporal mesial, prefrontal and parietal cortices in encoding during sentence generation and recognition. GE2REC is useful because it: (a) requires simultaneous and interactive language-and-memory processes and jointly maps their neural basis; (b) explores encoding and retrieval, managing to elicit activation of mesial temporal structures; (c) is easy to perform, hence being suitable for more restrictive settings, and (d) has an ecological dimension of tasks and stimuli. GE2REC may be useful for studying neuroplasticity of cognitive functions, especially in patients with temporal lobe epilepsy who show reorganization of both language and memory networks. Overall, GE2REC can provide valuable information in terms of the practical foundation of exploration language and memory interconnection.

show abstract

“…Some centers also use functional transcranial Doppler sonography (fTCD), transcranial magnetic stimulation (TMS), or magnetoencephalography (MEG) to assess HLL. HML is typically assessed through elaborate neuropsychological assessments, though a number of studies have investigated the use of verbal memory paradigms in fMRI for this purpose, as summarized by Massot-Tarrús et al 36 .…”

Section: Introductionmentioning

confidence: 99%

Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Conradi

Rosenberg

Knake

et al. 2021

Sci Rep

View full text Add to dashboard Cite

In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients’ verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R2 = 0.233, p = .032) and verbal memory function (∆R2 = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications.

show abstract

Comparing the Wada Test and Functional MRI for the Presurgical Evaluation of Memory in Temporal Lobe Epilepsy

Cited by 23 publications

References 114 publications

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Mapping of Language-and-Memory Networks in Patients With Temporal Lobe Epilepsy by Using the GE2REC Protocol

Interactive mapping of language and memory with the GE2REC protocol

Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Contact Info

Product

Resources

About