Comparing the Surgical Response of Bisphosphonate-Related Versus Denosumab-Related Osteonecrosis of the Jaws

Palla, Benjamin; Burian, Egon; Deek, Andrew; Scott, Christopher D.; Anderson, John A. E.; Callahan, Nicholas; Carlson, Eric R.

doi:10.1016/j.joms.2020.11.017

Cited by 7 publications

(13 citation statements)

References 43 publications

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“…Thus, although the MRONJ treatment options are under debate, and some authors still recommend surgical treatment only for the most severe, symptomatic stages of the disease or in case of failure of a conservative therapy (Ruggiero et al, 2022;Sacco et al, 2021), studies have shown that surgery seems to be effective for the treatment of MRONJ at any stage of the disease (Hauer et al, 2020). Palla et al (2021) reported in their study a surgical success rate for stage I MRONJ of 100%, 71.4% in stage 2 and 60.0% in stage 3. For Nisi et al (2020) their data indicated 100% disease resolution for all stage 2 lesions and 83.3% disease resolution for stage 3.…”

Section: Discussionmentioning

confidence: 99%

“…In 2003 this pathology was described by Marx, who reported cases of painful bone exposure in patients undergoing intravenous bisphosphonate therapy (Palla et al, 2021). Since then, the number of case reports of osteonecrosis of the jaw associated with other antiresorptive and antiangiogenic drugs has increased in the literature (Nisi et al, 2018).…”

Section: Soft Tissue Flapsmentioning

confidence: 99%

“…Therefore, surgical success is defined as maintaining mucosal closure without bone exposure and infection (Palla et al, 2021) and depends on the possibility of removing necrosis by limiting surgical trauma, smoothing the bone edges, controlling the progress of infection, promoting blood supply at the affected site, and achieving primary wound closure without soft tissue tension (El-Rabbany et al, 2019;Giudice et al, 2020).…”

Section: )mentioning

confidence: 99%

“…It was first described in 2003 by Robert Marx, who reviewed 36 cases of painful bone exposure in patients with a history of zoledronate and pamidronate usage, resorptive drugs used at the time, in the treatment of metastatic breast cancer and multiple myeloma (Palla et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The American Association of Oral and Maxillofacial Surgeons (AAOMS) published its first position paper on this form of osteonecrosis of the jaws in 2007, using the nomenclature bisphosphonate-related osteonecrosis of the jaws (Palla et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Surgical treatments for medication-related osteonecrosis of the jaws: advantages and limitations

Silva

Santiago

Campos

et al. 2023

RSD

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Objective: The purpose of this paper is to discuss the surgical methods available for the treatment of MRONJ, pointing out their advantages and limitations. Methodology: An integrative review of the literature was performed by searching the PubMed virtual database using the MeSH term "bisphosphonate associated osteonecrosis of the jaw/surgery" and including 26 publications. Results: Surgical intervention is presented as a treatment option in an attempt to reduce disease progression with the recognition that this early intervention may predict beneficial outcomes for the patient. Surgical approaches confer superior treatment outcomes over conservative treatments, with success rates of 80-90% and 10-62%, respectively. To establish treatment, consideration should be given to therapy for removing nonhealing exposed bone, which can be accomplished through curettage, sequestrectomy, and surgical resection. When approaching soft tissue, different flaps can be performed, according to their indications. Conclusion: Surgical treatment has shown maintenance of mucosal coverage, improved quality of life, and quick resumption of antiresorptive therapy for all stages of the disease, with high rates of therapeutic success. However, continued efforts should be encouraged to investigate the best treatment for this pathology.

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