Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars

Abstract

Among wound-healing modalities, platelet-rich plasma (PRP) has been used for wound healing, through the release of multiple growth factors. The platelets mediate wound healing by initiating the clotting pathway and the subsequent matrix remodelisation. The aim of the work was to study the role of injection of platelet-rich plasma in the treatment of scars. This study was conducted on thirty patients who were divided into two groups (A and B). Each group included fifteen patients. The two groups were randomly distributed by using individual sealed envelopes. Group A was subjected to subcision of their acne scars using Nokor needle, followed by suction. Group B patients were subjected to the same treatment but followed by an injection of platelet-rich plasma once per month over three months. In Group A, 6 patients (40%) showed moderate improvement, 5 patients (33.3%) showed slight improvement and 4 patients (26.7%) showed significant improvement. In Group B, 7 patients (46.7%) showed moderate improvement, 5 patients (33.3%) showed marked improvement and 3 patients (20%) showed significant improvement. There was a statistically significant difference on the independent observer's after-treatment assessment between the groups (P = 0.014). In conclusion, subcision suction leads to a persistent improvement of acne scars in a short time, and the coupling with injection of PRP is the most effective in the treatment of depressed facial scars.Keywords: Platelet-rich plasma; scars; subcision; suction Citation: Abou Khedr NAE, Hussein TM, Abd El-Fatah AME. Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars. J Surg Dermatol 2017; 2(2): 88-97; http://dx

Morphological Characteristics and Causes of Atrophic Scar Treat With Subcision and Platelet-Rich Plasma at the Can Tho Dermato-Venereology Hospital in 2021-2023

“…In our survey of the etiologies of scars, most patients had a history of acne leading to atrophic scars, accounting for 90%; only 6.7% of patients had post-varicella scars; and 3.3% had traumatic scars. According to Nouran Abd El, Aziz Abou Khedr, et al (2017), the cause of atrophic scars is mainly acne, accounting for 80%, and chicken pox, accounting for 10%, 6% due to trauma, and 4% due to surgery [1]. Thus, the results of the above study are similar to ours.…”

“…Scars result from a natural healing process that leads to the formation of fibrous tissue that replaces normal tissue destroyed by injury or disease [1]. Scar formation can result in keloid scarring due to increased fibrous tissue formation, but more commonly, atrophic scars are formed due to tissue loss or reduction at the site of injury [2].…”

Platelet-rich plasma in skin rejuvenation

“…Another study showed that combining PRP therapy with fractional resurfacing resulted in a rise in dermal elasticity and collagen thickness as well as a decrease in erythema [11] . Combining PRP with fractional lasers or subcision suction to treat atrophic acne scars has been shown to shorten the healing time, as well as to diminish erythema and edema, while encouraging keratinocyte, fibroblast, and collagen proliferation [12][13][14] . There might be some side effects when using PRP that the patient must be aware of before the procedure.…”