Comparing the qualitative performances of handheld NIR and Raman spectrophotometers for the detection of falsified pharmaceutical products

Ciza, P.H.; Sacré, Pierre-Yves; Waffo, Christelle; Coïc, Laureen; Avohou, Hermane T.; Mbinze, Jérémie Kindenge; Ngono, R.; Marini, R.D.; Hubert, Ph.; Ziémons, Eric

doi:10.1016/j.talanta.2019.04.049

Cited by 52 publications

(33 citation statements)

References 35 publications

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“…In this study, a data driven SIMCA (DD-SIMCA) has been employed. Similar to any SIMCA model, DD-SIMCA starts with the decomposition of the calibration spectra of the target class by PCA [10,35]. Then, the results of PCA decomposition is used to calculate a score distance (h i ) and an orthogonal distance (v i ) for each training sample.…”

Section: Dd-simcamentioning

confidence: 99%

“…Fortunately, some innovative handheld and low-cost NIR spectrophotometers (less than 1000 EUR) have recently appeared on the market. In addition to their low cost, these portable devices can offer a promising performance comparable to bench-top instruments [10,11]. The second group of analytical techniques concerns methods that require reagents and sample preparation, and for which different modifications must be applied to be conformed as much as possible to GAC concepts [12].…”

Section: Introductionmentioning

confidence: 99%

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Green Analytical Methods of Antimalarial Artemether-Lumefantrine Analysis for Falsification Detection Using a Low-Cost Handled NIR Spectrometer with DD-SIMCA and Drug Quantification by HPLC

Yabré

Ferey

Sakira³

et al. 2020

Molecules

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Two green analytical approaches have been developed for the analysis of antimalarial fixed dose tablets of artemether and lumefantrine for quality control. The first approach consisted of investigating the qualitative performance of a low-cost handheld near-infrared spectrometer in combination with the principal component analysis as an exploratory tool to identify trends, similarities, and differences between pharmaceutical samples, before applying the data driven soft independent modeling of class analogy (DD-SIMCA) as a one-class classifier for proper drug falsification detection with 100% of both sensitivity and specificity in the studied cases. Despite its limited spectral range and low resolution, the handheld device allowed detecting falsified drugs with no active pharmaceutical ingredient and identifying specifically a pharmaceutical tablet brand name. The second approach was the quantitative analysis based on the green and fast RP-HPLC technique using ethanol as a green organic solvent and acetic acid as a green pH modifier. The optimal separation was achieved in 7 min using a mobile phase composed of ethanol 96% and 10 mM of acetic acid pH 3.35 (63:37, v/v). The developed method was validated according to the total error approach based on an accuracy profile, was applied to the analysis of tablets, and allowed confirming falsified drugs detected by spectroscopy.

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Section: Dd-simcamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green Analytical Methods of Antimalarial Artemether-Lumefantrine Analysis for Falsification Detection Using a Low-Cost Handled NIR Spectrometer with DD-SIMCA and Drug Quantification by HPLC

Yabré

Ferey

Sakira³

et al. 2020

Molecules

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“…Notably, handheld NIR spectrometers face competition from Raman instruments in applications, in which cost‐effectiveness does not play a crucial role. The strengths and limitations of both techniques in the analysis of pharmaceutical products were directly compared, for example, in a recent study by Ciza et al [61] . The general conclusion was that miniaturized NIR spectroscopy was more reliable in specific product identification; however, the choice of a better technique might depend on the particular application.…”

Section: Miniaturized Nir Spectroscopy In Practical Applicationsmentioning

confidence: 99%

“…The general conclusion was that miniaturized NIR spectroscopy was more reliable in specific product identification; however, the choice of a better technique might depend on the particular application. It was suggested that the future appearance of cost‐effective instruments combining both NIR and Raman spectrometers would result in substantial progress [61] . A wider perspective of how portable NIR spectrometers compete with Raman instruments in the analysis of pharmaceuticals has been presented in a recent review article [62] …”

Section: Miniaturized Nir Spectroscopy In Practical Applicationsmentioning

confidence: 99%

Principles and Applications of Miniaturized Near‐Infrared (NIR) Spectrometers

Beć

Grabska

Huck

2020

Chemistry A European J

230

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This review article focuses on the principles and applications of miniaturized near‐infrared (NIR) spectrometers. This technology and its applicability has advanced considerably over the last few years and revolutionized several fields of application. What is particularly remarkable is that the applications have a distinctly diverse nature, ranging from agriculture and the food sector, through to materials science, industry and environmental studies. Unlike a rather uniform design of a mature benchtop FTNIR spectrometer, miniaturized instruments employ diverse technological solutions, which have an impact on their operational characteristics. Continuous progress leads to new instruments appearing on the market. The current focus in analytical NIR spectroscopy is on the evaluation of the devices and associated methods, and to systematic characterization of their performance profiles.

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“…Portable analyzers can be used in the field and reduce the number of samples that need to be tested in the laboratory [14,44,45]. Several handheld Raman scattering analyzers with different functions, sizes, and prices have been developed, and there are several reports that have evaluated their usefulness [7,8,14,[44][45][46][47][48][49][50][51]. The handheld Raman spectrometer is expected to be used in customs, warehouses, medical institutions, and pharmacies, and is cheaper than fixed Raman spectrometers installed in laboratories.…”

Section: Introductionmentioning

confidence: 99%

Discrimination of Falsified Erectile Dysfunction Medicines by Use of an Ultra-Compact Raman Scattering Spectrometer

et al. 2020

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Substandard and falsified medicines are often reported worldwide. An accurate and rapid detection method for falsified medicines is needed to prevent human health hazards. Raman scattering spectroscopy has emerged as a non-destructive analysis method for the detection of falsified medicines. In this laboratory study, Raman spectroscopy was performed to evaluate the applicability of the ultra-compact Raman scattering spectrometer (C13560). Principal component analysis (PCA) was also performed on the Raman spectra. This study analyzed tadalafil (Cialis), vardenafil (Levitra), and sildenafil (Viagra) tablets. We tested the standard product and products purchased from the internet (genuine or falsified). For Cialis and Levitra, all falsified tablets were identified by the Raman spectra and PCA score plot. For Viagra, the Raman spectra of some falsified tablets were almost comparable to the standard tablet. The PCA score plots of falsified tablets were dispersed, and some plots of falsified tablets were close to the standard tablet. In conclusion, C13560 was useful for the discrimination of falsified Cialis and Levitra tablets, whereas some falsified Viagra tablets had Raman spectra similar to that of the standard tablet. The development of detection methods that can be introduced in various settings may help prevent the spread of falsified products.

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Comparing the qualitative performances of handheld NIR and Raman spectrophotometers for the detection of falsified pharmaceutical products

Cited by 52 publications

References 35 publications

Green Analytical Methods of Antimalarial Artemether-Lumefantrine Analysis for Falsification Detection Using a Low-Cost Handled NIR Spectrometer with DD-SIMCA and Drug Quantification by HPLC

Green Analytical Methods of Antimalarial Artemether-Lumefantrine Analysis for Falsification Detection Using a Low-Cost Handled NIR Spectrometer with DD-SIMCA and Drug Quantification by HPLC

Principles and Applications of Miniaturized Near‐Infrared (NIR) Spectrometers

Discrimination of Falsified Erectile Dysfunction Medicines by Use of an Ultra-Compact Raman Scattering Spectrometer

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