“…These included four cohort studies, 21,22,28,29 seven case series 17–20,30–32 and nine cross‐sectional studies 33–41 . Five studies were from the United States, 21,22,29,35,41 four from Canada, 19,20,28,36 four from Germany, 17,18,31,32 two from Italy 39,40 and one each from Australia, 33 Spain, 34 Poland, 30 South Korea 37 and Brazil 38 . Of these, 12 studies were in clinical populations with sample sizes between 100 and 400 in six studies, 19,28,31,32,34,41 500 and 1000 in three studies 17,38,39 and greater than 1000 in two studies 18,20 .…”