“…Rate of alignment efficiency was evaluated by 5 studies, 9,10,11,18,20 space closure was evaluated by 7 studies, 9,10,11,14,18,20,23 pain and discomfort were reported by 3 studies 9,10,20 and periodontal condition and oral hygiene were evaluated by 7 studies. 10,11,13,17,19,21,22 Transverse arch dimensional changes were evaluated by 4 studies 10,17,18,24 and 1 study reported external apical resorption. 15 Methodological quality of all studies was positive to the following questions: The protocol provided a priori, had an adequate selection of studies by 2 independent reviewers, had a comprehensive search strategy, and provided characteristics of included studies.…”