Abstract:ObjectiveTo evaluate the perioperative complications of Single‐Port Robotic Radical Prostatectomy.Materials & MethodsA retrospective review was performed on the prospectively‐maintained, IRB‐approved, multi‐institutional Single‐Port Advanced Research Consortium (SPARC) database. A total of 1103 patients were identified who underwent three different approaches of SP‐RARP between 2019 and 2022 using the purpose‐built SP robotic. In addition to baseline clinical, perioperative outcomes, this study comprehensively analyzed for any evidence of intraoperative complication as well as postoperative complication and readmission within 90 days of the respective surgery.ResultsOf the 244, 712, and 147 patients who underwent transperitoneal, extraperitoneal, and transvesical SP‐RARP, respectively, intraoperative complications were noted in 5 patients (0.4%), all of which occurred during the transperitoneal approach. Two patients had bowel serosal tears, two had posterior button‐holing of the bladder necessitating repair, and one patient had an obturator nerve injury. Postoperative complications were noted in 143 patients (13%) with major complications (Clavien Grade ≥3) only identified in 3.7% of the total cohort. The most common complications were lymphocele (3.9%), acute urinary retention (2%), and urinary tract infection (1.9%). The 90‐day readmission rate was 3.9%.ConclusionSP‐RARP is a safe and effective procedure with low complication and readmission rates regardless of the approach. These results are comparable to current multi‐port robotic radical prostatectomy literature.