Comparing the neuropsychological profiles of mild dementia with Lewy bodies and mild Alzheimer’s disease

Abstract

Background: The present study was conducted to detect neuropsychological differences and to identify discriminators between mild dementia with Lewy bodies (DLB) and mild Alzheimer's disease (AD). Methods: The present study included 37 mild DLB patients, 48 mild AD patients, and 80 healthy elderly individuals. A comprehensive battery of neuropsychological tests was administrated to assess their cognitive function. Linear stepwise discriminant analysis was used to identify the neuropsychological measures with values that could differentiate between mild DLB and mild AD. Results: The mild DLB group had greater impairments in attention, executive function, and visuospatial ability, while mild AD patients performed significantly worse on memory tests. Linear stepwise discriminant analysis indicated that the Memory and Executive Screening's 5-min delayed recall test was the best neuropsychological discriminator between mild DLB and mild AD. Conclusions: Different patterns of cognitive impairment facilitate the differentiation of mild DLB from mild AD. For patients with mild dementia, better performance on the Memory and Executive Screening's 5-min delayed recall test suggests that the diagnosis is more likely DLB than AD.

Perfiles cognitivos-lingüísticos en personas mayores con Deterioro Cognitivo Leve, Demencia Vascular, Demencia con Cuerpos de Lewy y Enfermedad de Parkinson.

“…Comparing the neuropsychological profiles of mild dementia with Lewy bodies and mild Alzheimer's disease 31 Neuropsychological profile of dementia with Lewy bodies 21 Cognitive profile in prodromal dementia with Lewy bodies 32 Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease 33 Sentence processing in Lewy body spectrum disorder: the role of working memory 24 Cognitive fluctuations in connection to dysgraphia: a comparison of Alzheimer's disease with dementia Lewy bodies 34 A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia 19 Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies 35 Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology 36 Prodromal Dementia with Lewy Bodies: Clinical Characterization and Predictors of Progression…”

“…Comparing the neuropsychological profiles of mild dementia with Lewy bodies and mild Alzheimer's disease 31 Neuropsychological profile of dementia with Lewy bodies 21 Cognitive profile in prodromal dementia with Lewy bodies 32 Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease 33 Sentence processing in Lewy body spectrum disorder: the role of working memory 24 Cognitive fluctuations in connection to dysgraphia: a comparison of Alzheimer's disease with dementia Lewy bodies 34 A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia 19 Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies 35 Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology 36 Prodromal Dementia with Lewy Bodies: Clinical Characterization and Predictors of Progression Semantic Function in Mild Cognitive Impairment 53 Mild cognitive impairment and its management in older people 54 Petrova M, Mehrabian-Spasova S, Aarsland D, Raycheva M, Traykov L. Comparing the neuropsychological profiles of mild dementia with Lewy bodies and mild Alzheimer's disease 31 Neuropsychological profile of dementia with Lewy bodies 21 Cognitive profile in prodromal dementia with Lewy bodies 32 Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease 33 Sentence processing in Lewy body spectrum disorder: the role of working memory 24 Cognitive fluctuations in connection to dysgraphia: a comparison of Alzheimer's disease with dementia Lewy bodies 34 A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia 19 Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies 35 Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology 36 Prodromal Dementia with Lewy Bodies: Clinical Characterization and Predictors of Progression…”

“…Impairment 53 Mild cognitive impairment and its management in older people 54 Connected speech and language in mild cognitive impairment and Alzheimer's disease: A review of picture description tasks 55 Vocabulary Size in Speech May Be an Early Indicator of Cognitive Impairment 56 Deterioration of semantic associative relationships in mild cognitive impairment and Alzheimer Disease 57 Patterns of semantic memory impairment in Mild Cognitive Impairment 58 Episodic, but not semantic, autobiographical memory is reduced in amnestic mild cognitive impairment 59 The cognitive and neural expression of semantic memory impairment in mild cognitive impairment and early Alzheimer's disease 60 Working memory binding and episodic memory formation in aging, mild cognitive impairment, and Alzheimer's dementia 61 Multiple cognitive deficits in amnestic mild cognitive impairment 62 Detecting subtle changes in visuospatial executive function and learning in the amnestic variant of mild cognitive impairment 63 Selectivity of executive function deficits in mild cognitive impairment 64 Taler V, Monetta L, Sheppard C, Ohman A. Comparing the neuropsychological profiles of mild dementia with Lewy bodies and mild Alzheimer's disease 31 Neuropsychological profile of dementia with Lewy bodies 21 Cognitive profile in prodromal dementia with Lewy bodies 32 Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease 33 Sentence processing in Lewy body spectrum disorder: the role of working memory 24 Cognitive fluctuations in connection to dysgraphia: a comparison of Alzheimer's disease with dementia Lewy bodies 34 A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia 19 Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies 35 Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology 36 Prodromal Dementia with Lewy Bodies: Clinical Characterization and Predictors of Progression 37 The The overall impairment of core executive function components in patients with amnestic mild cognitive impairment: a cross-sectional study 65 Pattern of cognitive deficits in vascular dementia 27 Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vas...…”

“…Sengupta P, Ganguly J, Pal S, Ghosal M. Comparing the neuropsychological profiles of mild dementia with Lewy bodies and mild Alzheimer's disease 31 Neuropsychological profile of dementia with Lewy bodies 21 Cognitive profile in prodromal dementia with Lewy bodies 32 Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease 33 Sentence processing in Lewy body spectrum disorder: the role of working memory 24 Cognitive fluctuations in connection to dysgraphia: a comparison of Alzheimer's disease with dementia Lewy bodies 34 A review of cognitive impairments in dementia with Lewy bodies relative to Alzheimer's disease and Parkinson's disease with dementia 19 Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies 35 Narrative Organization Deficit in Lewy Body Disorders Is Related to Alzheimer Pathology 36 Prodromal Dementia with Lewy Bodies: Clinical Characterization and Predictors of Progression 37 The Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests 71 The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia 72 The Dementia Rating Scale (DRS) in the diagnosis of vascular dementia 73 Matioli MN, Caramelli P. Por otra parte, para DV, DPCL y EP se reporta mayor frecuencia en la utilización de pruebas como Clock Drawing Test, WAIS Logical Memory: Delayed Recall, Verbal Fluency, Magnetic Imaging Resonance y Clinical Dementia Rating Scale.…”

Comparing the Clinical and Neuropsychological Characteristics of Parkinson’s Disease With and Without Freezing of Gait

“…All participants underwent a comprehensive battery of neuropsychological tests, evaluating global cognition, memory function, executive function, language function, attention and working memory, visuospatial ability, and emotion recognition ability (Xu et al, 2018). These tests were conducted by a trained neurology MD.…”