Comparing the Multifocal Electroretinogram Topography before and after Cataract Surgery

Abstract

Nuclear cataract could affect the topography of mfERG, so clinicians should be aware of the effects of cataract when interpreting mfERG responses in cataract patients.

Temporal interactive response is resistant to cloudy ocular media in the slow double-stimulation multifocal electroretinogram

“…However, the late portion of the slow double-stimulation paradigm consists of less overlap of the response associated with subsequent flashes, owing to the presence of three dark frames at the end of each cycle. Previous studies using conventional mfERG stimulation showed that the central mfERG response amplitude was affected by cataract20 21 and light scattering 8. Our findings for the M 1 response are consistent with previous studies showing that the central mfERG response amplitude is influenced by light scatter, including that produced by cataract.…”

Multifocal Electroretinography

“…Reduction of the amplitudes of the waves N1 and P1 seems to be in proportion to the severity of the opacity of the lens. 7 Others have considered that loss of photoreceptors and ganglion cells over time may be primarily responsible for changes in the mf ERG in older individuals. [8][9][10][11] Incomplete degradation of the outer segments of the photoreceptors and loss of function of ABCA4 gene (found in Stargardt's patients) may provoke the accumulation of lipofucsin in the retinal pigment epithelium and may also be a factor.…”

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

“…Tam et al and Palmowski et al also demonstrated increases in mfERG responses in eyes which had undergone cataract surgery. 228,297 In another study conducted by Wördehoff et al, it was shown that there were significant increases in P1 response amplitudes in the central macula after cataract surgery, while no significant changes in N1 and P1 implicit times were observed. 315 Besides assessing the mfERG changes in cataract patients, studies using artificial light scattering have also been performed to mimic the effects of cataract on mfERG.…”

“…228,297,299,315,326 Tam et al studied the effects of different cataract severity on mfERG recordings. 299 It was shown that N1 and P1 response amplitudes from the central macula were significantly reduced in subjects with mild or moderate cataract compared with subjects with very mild cataract.…”