Comparing the Gleason Prostate Biopsy and Gleason Prostatectomy Grading System: The Lahey Clinic Medical Center Experience and an International Meta-Analysis

The role of PSA density to predict a pathological tumour upgrade between needle biopsy and radical prostatectomy for low risk clinical prostate cancer in the modified Gleason system era

“…In a recent meta-analysis of 14 839 patients, the authors reported a concordance between biopsy and prostatectomy grade in 63%, while an upgrade was found in 30% of patients. 13 Other higher rates have been published. [4][5][6][7][8] This observation has important pathological and prognostic aspects.…”

Multi-institutional Validation of the CAPRA-S Score to Predict Disease Recurrence and Mortality After Radical Prostatectomy

“…Pretreatment variables such as clinical T stage, biopsy Gleason grade, and percentage of positive biopsy cores provide only an approximation of cancer severity and may overestimate or underestimate cancer grade or extent [14,15]. An advantage of radical prostatectomy (RP) is that it provides a more accurate assessment of grade and stage that may improve prognostic accuracy.…”

Evaluation of Prostate Cancer with PET/MRI

“…This approach has been criticized because it often yields an overdiagnosis of indolent disease and an underdiagnosis of clinically significant cancer (3,4). mpMRI can be used to assist prostate biopsies through image guidance.…”