Comparing the Efficacy of Triamcinolone Acetonide Iontophoresis versus Topical Calcipotriol/Betamethasone Dipropionate in Treating Nail Psoriasis: A Bilateral Controlled Clinical Trial

Saki, Nasrin; Hosseinpoor, Shahla; Heiran, Alireza; Mohammadi, Ali; Zeraatpishe, Mehdi

doi:10.1155/2018/2637691

Cited by 20 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2018, a study conducted by Saki et al compared the therapeutic effects of triamcinolone acetonide iontophoresis (TI) and topical calcipotriol/betamethasone dipropionate. The results demonstrated that there was no difference between effects of TI versus topical therapy in terms of nail bed score ( p = 0.356), matrix score ( p = 0.137), and total NAPSI ( p = 0.098) [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Nail Psoriasis: A Review of Effective Therapies and Recommendations for Management

Hadeler

Mosca

Hong

et al. 2021

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

Nail psoriasis has a prevalence that ranges from 10 to 82% and can significantly impact the quality of life of patients. Nail psoriasis is one of the most challenging areas to treat, and multiple therapies have been explored. Topical and injectable therapies are recommended for fewnail disease. Systemic therapies, including biologics, can be considered for patients with multiple and resistant nail disease, impaired quality of life, and severe skin and joint involvement, due to their long-term efficacy. Although outcome data are difficult to compare, interleukin (IL)-17 inhibitors may have superior short-term efficacy when compared to IL-23 inhibitors and tumor necrosis factor (TNF)-alpha inhibitors, although long-term efficacy is similar to TNF-alpha inhibitors. IL-23 inhibitors and TNF-alpha inhibitors have a similar efficacy for nail psoriasis.

show abstract

Section: Resultsmentioning

confidence: 99%

Nail Psoriasis: A Review of Effective Therapies and Recommendations for Management

Hadeler

Mosca

Hong

et al. 2021

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

show abstract

“…The use of galvanic current in the treatment of pathologies with microvascular dysfunction such as hyperhidrosis 27 or nail psoriasis 28 has been widely reported; however, studies of its effectiveness in Raynaud's phenomenon are still scarce. Previous studies 11,29 that used galvanic current in combination with drugs in patients with Raynaud's phenomenon secondary to systemic sclerosis showed that digital skin perfusion increased after a single session.…”

Section: Discussionmentioning

confidence: 99%

The complementary effects of galvanic current electrical stimulation associated with conservative treatment to increase vasodilation in patients with Raynaud’s phenomenon: a randomized trial

et al. 2020

View full text Add to dashboard Cite

Objective: To analyze the effectiveness of an electrotherapy intervention with galvanic current on symptoms associated with Raynaud’s phenomenon. Design: Single-blind randomized controlled trial, parallel design (1:1 ratio) and intention-to-treat analysis. Setting: Virgen de las Nieves Hospital, Granada, Spain. Subjects: Thirty-four participants with Raynaud’s phenomenon, with a mean (SD) age of 43.43 (17.62) years. Interventions: The patients were randomly assigned to a control group with conservative treatment (anti-inflammatory, vasodilatory and analgesic drugs) or an intervention group that received conservative treatment and vasodilatory electrical stimulation during seven weeks, three times/week for a total of 20 sessions. Main measures: The primary outcome was the number of attacks. Secondary outcomes were pain, peripheral blow flow, oxygen saturation, upper limb disability, central sensitization, pain catastrophizing and temperature recovery. All outcomes were assessed at baseline, posttreatment and at two months of follow-up. Results: The galvanic current electrotherapy group showed significantly greater improvements in the number of attacks (mean difference = 26.3, 95% confidence interval (CI) = 14.4 to 38.3), pre-cold stress pain (95% CI = 0.6 to 2.4), radial artery blood flow (95% CI = −7.8 ⩾ x ⩽ 1.3), ulnar artery blood flow (95% CI = −8.63 to 0.60), oxygen saturation (95% CI = −1.7 ⩾ x ⩽ −0.29), upper limb disability (95% CI = 1.1 to 22.3), central sensitization (95% CI = 6.7 to 18.2) and temperature recovery (95% CI = −5.7 ⩾ x ⩽ −0.32) than the conservative treatment group. Conclusion: This study suggests that a complementary treatment with galvanic current in combination to conservative approach is superior to conservative applied as isolate, in reducing the clinical manifestations and disability in Raynaud’s phenomenon.

show abstract

“…An average improvement of 72% was observed in the nail psoriasis severity index (NAPSI). Saki et al [ 30 ] investigated 16 patients with nail psoriasis treated with an ointment formulation for 6 months and observed a mean improvement of 55.5% in the NAPSI.…”

Section: Special Locationsmentioning

confidence: 99%

“…ointment appears to be more effective compared to foam in nail psoriasis (no head-to-head data) [ 30 , 31 , 48 ]…”

Section: Figurementioning

confidence: 99%

Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment

Rudnicka

Olszewska

Goldust

et al. 2021

JCM

View full text Add to dashboard Cite

Preparations containing calcipotriol combined with betamethasone dipropionate (in the forms of ointment, gel, and foam) are available for the topical treatment of psoriasis. This review summarizes the differences in the efficacy and safety of these formulations, as well as the preferences of patients with various forms of psoriasis (plaque, scalp, and nail psoriasis). It has been documented that foams provide higher bioavailability, resulting in increased efficacy in plaque psoriasis compared to ointments and gels. Gels or foams are preferred by patients for their different practical qualities (e.g., gels for “easy application”, and foams for “immediate relief”). The available data indicate that ointments may be the most effective formulation in nail psoriasis, and gels are preferred by patients with scalp psoriasis because of their cosmetic features. Treatment with a foam formulation is associated with a lower number of medical appointments compared to treatment with an ointment and with a lower probability of developing indications for systemic treatment. The safety profiles of foams, ointments, and gels are comparable, with the most common adverse effect being pruritus at the application site (in 5.8% of the patients). A long-term proactive maintenance therapy markedly reduces the number of relapses and is likely to close the gap between topical and systemic treatment in psoriasis.

show abstract

Comparing the Efficacy of Triamcinolone Acetonide Iontophoresis versus Topical Calcipotriol/Betamethasone Dipropionate in Treating Nail Psoriasis: A Bilateral Controlled Clinical Trial

Cited by 20 publications

References 27 publications

Nail Psoriasis: A Review of Effective Therapies and Recommendations for Management

Nail Psoriasis: A Review of Effective Therapies and Recommendations for Management

The complementary effects of galvanic current electrical stimulation associated with conservative treatment to increase vasodilation in patients with Raynaud’s phenomenon: a randomized trial

Efficacy and Safety of Different Formulations of Calcipotriol/Betamethasone Dipropionate in Psoriasis: Gel, Foam, and Ointment

Contact Info

Product

Resources

About