Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial

Maghsoudi, Robab; Farhadiniaki, Saeed; Etemadian, Masoud; Kashi, Amir Hossein; Shadpour, Pejman; Shirani, Asemaneh; Samadinezhad-Khoshbaf-Sorkhabi, Rana; Tabatabaei, M.

doi:10.1089/end.2017.0563

Cited by 15 publications

(16 citation statements)

References 20 publications

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“…A lot of studies have evaluated the adverse effects of cystoscopy in the literature. However, most of them have investigated the management of pain and discomfort in the patients who underwent cystoscopy (10)(11)(12) . A few studies have compared between rigid and flexible cystoscopies but the diameters of the cystoscopes in these studies were not equal (5,6) .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Pain, Quality of Life, Lower Urinary Tract Symptoms and Sexual Function Between Flexible and Rigid Cystoscopy in Follow-Up Male Patients With Non Muscle Invasive Bladder Cancer: A Randomized Controlled Cross Section Single Blind Study

Üçer

Temeltaş

Gümüş

et al. 2020

Preprint

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Objectives: To compare pain, quality of life(QoL), sexual function and lower urinary tract symptoms(LUTS) between rigid(RC) and flexible cystoscopy(FC). Methods: Forty-one patients who were planned control cystoscopies were enrolled the study. At the first cystoscopy, 20 patients(Group 1) and other 21 patients(Group 2) were performed by using flexible(15,5Fr) and rigid cystoscope(15,5Fr), respectively. At the second cystoscopies, the patients in group 1 and group 2 were performed by using rigid and flexible cystosacope, respectively. In all the patients, pain was measured with visual pain scale(VPS) shortly after cystoscopy. Also SF, QoL and LUTS were assessed by using IIEF, SF-36 and MLUTS forms, respectively. Results: While 22 of the patients preferred FC, the other 19 preferred RC(p>0,05). There were no statistically differences between VPS, IIEF, SF-36 and MLUTS scores of the two groups. In multivariate analysis regarding quality of life, although sexual function, pain and cystoscopy type did not affect QoL, voiding symptoms affected independently QoL. After the both cystoscopy type, IIEF, SF-36 and MLUTS scores did not change statistically. Conclusion: The results showed that the effects on pain, sexual function, QoL and LUTS of RC and FC were similar. In general, cystoscopy did not affect negatively on QoL, sexual function and LUTS of the patients.

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Section: Discussionmentioning

confidence: 99%

Comparison of Pain, Quality of Life, Lower Urinary Tract Symptoms and Sexual Function Between Flexible and Rigid Cystoscopy in Follow-Up Male Patients With Non Muscle Invasive Bladder Cancer: A Randomized Controlled Cross Section Single Blind Study

Üçer

Temeltaş

Gümüş

et al. 2020

Preprint

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show abstract

“…However, most of them have investigated the management of pain and discomfort in the patients who underwent cystoscopy. [10][11][12] A few studies have compared between rigid and flexible cystoscopies but the diameters of the cystoscopes in these studies were not equal. 5,6 Cicione et al also reported the lack of studies regarding the comparison of these cystoscopies in the literature.…”

Section: Discussionmentioning

confidence: 99%

Comparison of pain, quality of life, lower urinary tract symptoms and sexual function between flexible and rigid cystoscopy in follow‐up male patients with non muscle invasive bladder cancer: A randomized controlled cross section single blind study

et al. 2020

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Objectives To compare pain, quality of life (QoL), sexual function and lower urinary tract symptoms (LUTS) between rigid (RC) and flexible cystoscopy (FC). Methods Forty‐one patients who were planned control cystoscopies were enrolled the study. At the first cystoscopy, 20 patients (Group 1) and other 21 patients (Group 2) were performed by flexible (15.5 Fr) and rigid cystoscope (15.5 Fr), respectively. At the second cystoscopies, the patients in group 1 and group 2 were performed by rigid and flexible cystosacope, respectively. In all the patients, pain was measured with visual pain scale (VPS) shortly after cystoscopy. Also, SF, QoL and LUTS were assessed by IIEF, SF‐36 and MLUTS forms, respectively. Results While 22 of the patients preferred FC, the other 19 preferred RC (P > 0.05). There were no statistical differences between VPS, IIEF, SF‐36 and MLUTS scores of the two groups. In multivariate analysis regarding the quality of life, although sexual function, pain and cystoscopy type did not affect QoL, voiding symptoms affected independently QoL. After both cystoscopy type, IIEF, SF‐36 and MLUTS scores did not change statistically. Conclusion The results showed that the effects on pain, sexual function, QoL and LUTS of RC and FC were similar. In general, cystoscopy did not affect negatively on QoL, sexual function and LUTS of the patients.

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“…CRBD leads to restlessness, delirium, decreased satisfaction, and a rise in postoperative complications, such as incision rupture, bleeding, hemodynamic instability, the severity of coronary heart disease. [1] Thus, how to relieve postoperative CRBD, reduce the incidence of related complications, improve patient satisfaction, and shorten the time of anesthesia recovery observation has become needs to be resolved urgently in clinical practice [6][7][8][9]. Dexmedetomidine (Dex) is a type of high selective adrenergic α-2 receptor agonist, which has the effects of sedation, analgesia, and anti-anxiety.…”

Section: Clinical Trial Registration: Chinese Clinical Trial Registrymentioning

confidence: 99%

Dexmedetomidine intravesical instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study

Chen

Wang

et al. 2020

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Background The catheter-related bladder discomfort (CRBD) of male patients is a common clinical problem, albeit lacking effective solutions. The present study aimed to investigate whether dexmedetomidine intravesical instillation alleviates the postoperative urinary discomfort in male patients with catheter under general anesthesia.Methods This single-blinded, prospective, randomized study included a total of 167 male patients American Society of Anesthesiologists (ASA) physical status I-II scheduled for surgery under general anesthesia were allocated to two groups: 84 in the dexmedetomidine (Dex) group and 83 in the control group. Dex group patients received intravesical instillation of the drug 0.5 µg/kg and normal saline 20 mL, while the control group received intravesical instillation of 20 mL normal saline. The catheter was clamped for 30 min after intravesical instillation for all patients. Bladder stimulation scales and urethra pain numerical rating scale (NRS) scores were measured at admittance to post-anesthesia care unit (PACU) (T0), intravesical instillation (T1), 30 min (T2), 60 min (T3), 2 h (T4) after intravesical instillation, discharged from PACU (T5), and 6 h (T6) and 24 h (T7) after the operation. Patient satisfaction at discharge from PACU and 24 h post-operation were compared between the two groups.Results Bladder stimulation scales and urethra pain NRS scores after 30 min of dexmedetomidine intravesical instillation to 24 h post-operation were significantly lower than the control group (p < 0.001), and patient satisfaction was higher at discharge from PACU and 24 h post-operation (p < 0.001). No differences were detected in Steward score out of PACU (p = 0.213) and from the time of the end of operation to fully awake (p = 0.417).Conclusion Dex intravesical instillation reduces postoperative urinary discomfort and urethra pain and improves satisfaction in male patients under general anesthesia.Clinical Trial Registration: Chinese Clinical Trial Registry (No. ChiCTR1800016429), date of registration 1st June 2018

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Comparing the Efficacy of Tolterodine and Gabapentin Versus Placebo in Catheter Related Bladder Discomfort After Percutaneous Nephrolithotomy: A Randomized Clinical Trial

Abstract: Preoperative administration of oral tolterodine or gabapentin reduces postoperative CRBD and the need for rescue analgesics as much as 24 hours after surgery. Patients with history of Double-J insertion experience less CRBD.

Cited by 15 publications

References 20 publications

Comparison of Pain, Quality of Life, Lower Urinary Tract Symptoms and Sexual Function Between Flexible and Rigid Cystoscopy in Follow-Up Male Patients With Non Muscle Invasive Bladder Cancer: A Randomized Controlled Cross Section Single Blind Study

Comparison of Pain, Quality of Life, Lower Urinary Tract Symptoms and Sexual Function Between Flexible and Rigid Cystoscopy in Follow-Up Male Patients With Non Muscle Invasive Bladder Cancer: A Randomized Controlled Cross Section Single Blind Study

Comparison of pain, quality of life, lower urinary tract symptoms and sexual function between flexible and rigid cystoscopy in follow‐up male patients with non muscle invasive bladder cancer: A randomized controlled cross section single blind study

Dexmedetomidine intravesical instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study

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