Comparing the efficacy and safety of Q-switched and picosecond lasers in the treatment of nevus of Ota: a systematic review and meta-analysis

Williams, Natalie M.; Gurnani, Pooja; Long, Jun; Reynolds, John M.; Pan, Yue; Suzuki, Takahiro; Alhetheli, Ghadah; Nouri, Keyvan

doi:10.1007/s10103-020-03125-9

Cited by 12 publications

(18 citation statements)

References 43 publications

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“…Hypermelanosis are characterized by the accumulation of melanin at different levels of the skin. The mechanism of the Q-Switched laser primarily relies on the photomechanical effect to destroy the targeted tissue, accompanied by a diminished photothermal effect [ 10 , 11 , 12 ]. Hypermelanoses should be treated with lasers only when malignancy risk is excluded.…”

Section: Discussionmentioning

confidence: 99%

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study

Nisticò

Cannarozzo

Provenzano³

et al. 2021

Clinics and Practice

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(1) Benign hyperpigmentations are a common problem in cosmetic dermatology. Melasma, solar lentigo, and other acquired hyperpigmentations represent an aesthetic issue for an increasing number of patients. The gold standard in managing this condition is currently 1064/532 nanometers (nm) Q-Switched lasers. This study reports our experience on the use of a Q-switched laser with a nanosecond pulse to treat these conditions. (2) Methods: A total of 96 patients asking for benign hyperpigmentation removal were consecutively enrolled at the Magna Graecia University of Catanzaro and Tor Vergata University of Rome. Treating parameters were the following: 1064 nm with a pulse duration of 6 nanoseconds (ns) for dermic lesions and 532 nm with 6 ns for epidermal ones. Up to five treatments with a minimum interval between laser treatments of thirty days were performed. A follow-up visit three months after the last session assessed patient satisfaction with a Visual Analogue Scale (VAS). Two blinded dermatologists assessed the cosmetic result using a five-point scale comparing pictures before treatment and at follow-up. (3) Results: 96 patients were included; 47 participants were women (49.0%) and 49 men (51.0%). The mean reported age was 50.0 ± 17.3 years. All patients reached a good to complete hyperpigmentation removal at the dermatological evaluation with a mean VAS score of 8.91 ± 1.07. (4) Conclusions: Q Switched 1064/532 nm laser may be considered the gold standard treatment for benign hyperpigmentations. Our results confirm the literature findings on the effectiveness of these devices.

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Section: Discussionmentioning

confidence: 99%

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study

Nisticò

Cannarozzo

Provenzano³

et al. 2021

Clinics and Practice

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“…16 As melanin is the target chromophore for picosecond and Q-switched lasers, it absorbs shorter wavelengths more strongly compared with longer ones. 17 The absorption of 1064-nm photons by melanin is thus less optimal than 755 nm photons, 4 which might be translated into less damage to the dermal melanocytes upon laser irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…13 PIH was observed only in one (1/16, 6.25%) patient in our research, this incidence was similar to QSNL (pooled adverse event rate: 5%) and lower than other Q-switched lasers and PSAL. 4 The observed higher safety of PSNL is likely caused by its longer wavelength, which allows for decreased epidermal melanin light absorption and thus a lower risk of hyperpigmentation. 21 Besides, the longer treatment interval of some patients may also play a part.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of nevus of Ota with 1064 nm picosecond Nd:YAG laser: A retrospective study

Yang

Guo

Jia

et al. 2021

Dermatologic Therapy

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Nevus of Ota has been successfully treated by lasers. Currently, 1064 nm picosecond Nd:YAG lasers have become available for the treatment of pigmented disorders. However, there are few studies concerning the application of 1064 nm picosecond Nd:YAG laser in nevus of Ota. This study aimed to evaluate the efficacy and safety of a 1064 nm picosecond Nd:YAG laser for the treatment of nevus of Ota. We conducted a retrospective analysis of Chinese patients with nevus of Ota who had been treated with a 1064 nm picosecond Nd:YAG laser. Those who had any other laser treatment during the period of picosecond laser treatment were excluded. Via a visual analog scale for percentage of pigmentary clearance in standard photographs, the treatment efficacy was assessed by three blinded physician evaluators. A total of 16 subjects were included in this retrospective study. The average age at the beginning of treatment was 16.87 years old (range of 4 months to 59 years), and all patients were of Fitzpatrick skin type IV. Total treatment ranged from 1 to 5 sessions.A 1064 nm picosecond Nd:YAG laser with a mean fluence of 1.8-4.3 J/cm 2 was used at 3-12 month intervals. The mean efficacy score for all 16 patients was 2.56 after one session, and the mean efficacy score of 13 patients who completed two sessions and nine patients who completed three sessions were 3.15 and 3.51, respectively.

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“…We may define hyperpigmentations as the storage of a pigment such as melanin into the skin layers. Q-Switched lasers use the photomechanical effect to destroy the targeted chromophores, having no or minimal photothermal effect on surrounding tissues [13][14][15]. Only hyperpigmentations not associated with the risk of degeneration in malignancies should be treated with lasers; other hypermelanotic lesions, such as dysplastic nevi, should be handled with surgery.…”

Section: Discussionmentioning

confidence: 99%

Q-Switched 1064/532 nm Laser with Picosecond Pulse to Treat Benign Hyperpigmentations: A Single-Center Retrospective Study

et al. 2021

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(1) Benign melanoses are a frequent issue in aesthetic dermatology. Solar lentigo, ephelides, café au lait spots, and other melanoses represent a cosmetic issue for a growing number of subjects. The Q-switched 1064/532-nanometer (nm) laser may be considered the gold standard for management of these aesthetic issues. A new generation of Q-switched lasers, capable of concentrating the energy pulse in the spectrum of hundreds of picoseconds, is emerging, promising better results than previous ones. In this paper, we report the use of a Q-switched laser with a picosecond pulse to manage hypermelanoses. (2) Methods: 36 patients seeking melanosis removal were retrospectively enrolled at Magna Graecia University of Catanzaro. Treatment parameters, although variable, were the following: 1064 nm with a pulse duration of 450 picoseconds (ps) for dermic lesions and 532 nm with 370 ps for epidermal lesions. Up to four treatments, with a minimum interval between laser treatments of 30 days, were performed. After the last session, patients’ satisfaction was assessed at a three-month follow up with a Visual Analogue Scale (VAS). Two blinded dermatologists measured the aesthetic outcome using a five-point scale comparing pictures before laser sessions and during follow-up. (3) Results: 36 patients were enrolled; 23 were females (63.9%) and 13 males (36.1%). The mean reported age was 49.2 ± 18.9 years. All participants were assessed with a complete/almost complete melanosis removal at the dermatological evaluation, with a mean VAS score of 9.39 ± 0.90. (4) Conclusions: The Q-switched 1064/532 nm laser may be considered the main weapon in treating benign hypermelanosis. The picosecond pulse seems to guarantee better results than other devices. However, a clinical trial comparing Q-switched nanosecond pulse with picosecond pulse is necessary to confirm this study’s findings.

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Comparing the efficacy and safety of Q-switched and picosecond lasers in the treatment of nevus of Ota: a systematic review and meta-analysis

Cited by 12 publications

References 43 publications

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study

Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study

Treatment of nevus of Ota with 1064 nm picosecond Nd:YAG laser: A retrospective study

Q-Switched 1064/532 nm Laser with Picosecond Pulse to Treat Benign Hyperpigmentations: A Single-Center Retrospective Study

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