Comparing the effects of crocin at different doses on excitability and long-term potentiation in the CA1 area, as well as the electroencephalogram responses of rats under chronic stress

Dastgerdi, Azadehalsadat Hosseini; Radahmadi, Maryam; Pourshanazari, Ali Asghar

doi:10.1007/s11011-021-00747-y

Cited by 8 publications

(5 citation statements)

References 44 publications

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“…Therefore, it seems that brain response to crocin depends on not only the dose of crocin but also the type of stress. The comparison between the present study and Hosseini Dastgerdi et al (2021) study confirmed that isolation stress was more destructive than emotional stress induced by restraint stress on memory ( Hosseini Dastgerdi et al, 2021 ). Because a high dose of crocin was necessary for the improvement of memory in isolation stress with respect to restraint stress.…”

Section: Discussionsupporting

confidence: 79%

“…Also, chronic isolation stress increased the corticosterone levels in both the frontal cortex and hippocampus, whereas the glucose levels did not change in these regions. In this way, some previous reports demonstrated the role of stress on excitability impairments and Long-term plasticity deficit in other hippocampal areas ( Artola, 2008 ; Radahmadi, Hosseini, & Nasimi, 2014 ; Sun et al, 2020 ) and even with other types of stress ( Hosseini Dastgerdi et al, 2021 ). Moreover, different factors affect brain functions in stress conditions, such as the severity, period and pattern, and nature of stressors ( Radahmadi, Alaei, Sharifi, & Hosseini, 2015 ).…”

Section: Discussionmentioning

confidence: 57%

“…Another finding revealed that daily chronic administration of crocin (doses of 30 and 60 mg/kg) improved the destructive effects of chronic isolation stress on excitability and Long-term plasticity. However, Hosseini Dastgerdi et al (2021) reported that low doses of crocin were more beneficial for memory improvement due to restraint stress which was indicated as emotional stress ( Hosseini Dastgerdi et al, 2021 ). Also, a dose of 30 mg/kg of crocin improved spatial memory by more than 15 mg/kg in a behavioral test in subjects with 6 h/d restraint stress ( Ghadrdoost et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

“…The electrophysiological recording (in-vivo input/output functions and LTP) procedures from the hippocampal CA1 area were based on Hosseini Dastgerdi, et al (2021) study in urethane-anesthetized rats ( Dastgerdi, Radahmadi, & Reisi, 2020 ). Therefore, following stimulation of the Sch collateral pathway, extracellularly-evoked responses were obtained in this study.…”

Section: Methodsmentioning

confidence: 99%

“…Memory impairments can be caused by changes in the hippocampus and frontal cortex functions via alterations of stress mediators under emotionally stressful conditions ( Holtzer et al, 2017 ; Hosseini Dastgerdi, Radahmadi, & Pourshanazari, 2021 ; Mao, Huang, Zhong, Xian, & Ip, 2014 ). Therefore, the HPA axis affects Long-term potentiation (LTP) as a significant type of synaptic plasticity via glucocorticoid secretion ( Cazakoff & Howland, 2010 ; MacDougall & Howland, 2013 ; Mrdalj et al, 2013 ) and glucose levels (as another critical memory and stress mediator) in a different region of the brain ( Nugent et al, 2013 ; Persson, Sim, Virding, Onishchenko, Schulte, & Ingelman-Sundberg, 2014 ; Radahmadi et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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The Protective Effects of Crocin on Input-Output Functions and Long-term Potentiation of Hippocampal CA1 Area in Rats Exposed to Chronic Social Isolated Stress

Khani

Radahmadi

Alaei

2022

BCN

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Background: The lack of social communication is associated with the premiere risk of brain functions. While it is reported that crocin is helpful for it. This study investigated the protective effect of two doses of crocin on hippocampal LTP in the CA1 area as a cellular mechanism in rats under chronic isolation stress. Methods: Rats were assigned into the control, sham, isolation stress, two stress groups receiving doses of 30 and 60 mg/kg crocin. Chronic isolation stress(CIS) was induced 6h/day and crocin administrated over a period of 21days. The fEPSP slope and amplitude were measured in input/output functions and LTP induction in the CA1 area of the hippocampus. Also, the corticosterone and glucose levels were assayed in the hippocampus and frontal cortex. Results: The slope and amplitude of fEPSP severity were impaired in both input/output and LTP responses by the CIS group. Whereas, crocin at dose of 30 and particularly 60 mg/kg improved them in the CIS group. Also, the corticosterone levels significantly increased in the frontal cortex and especially the hippocampus. Whereas, only a high dose of crocin was able to decrease hippocampal corticosterone levels in the CIS condition. Finally, the glucose levels did not alter in the hippocampus and frontal cortex in all experimental groups. Conclusion: The chronic isolation stress impaired neural excitability and the intensity of long-term plasticity in the CA1 area due to elevated corticosterone in the hippocampus and probably the frontal cortex. Whereas, the low and high doses of crocin improved excitability and long-term plasticity in the chronic isolation stress group by only decreasing corticosterone levels in the hippocampus, but not the frontal cortex.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Protective Effects of Crocin on Input-Output Functions and Long-term Potentiation of Hippocampal CA1 Area in Rats Exposed to Chronic Social Isolated Stress

Khani

Radahmadi

Alaei

2022

BCN

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The protective effects of escitalopram on synaptic plasticity in the CA1 region of chronically stressed and non‐stressed male rats

Farahbakhsh

Radahmadi

2022

Intl J of Devlp Neuroscience

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Introduction Stress impairs cognitive processes and escitalopram affects them in various ways. The present study has compared the protective effects of two escitalopram doses on neural excitability and synaptic plasticity in the CA1 region of chronically stressed and non‐stressed male rats. Methods Forty‐nine rats were randomly allocated into seven groups: Control (Co), stress (St), sham (Sh), escitalopram 10 and 20 mg/kg (Esc10 and Esc20), and stress‐escitalopram 10 and 20 mg/kg (St‐Esc10 and St‐Esc20). Induction of restraint stress (6 h/day) and escitalopram injections were performed for 14 days. The fEPSP slope and amplitude were measured according to input–output functions and after the LTP induction in the hippocampal CA1 region. Also, serum corticosterone levels were evaluated in all experimental groups. Results The fEPSP slope and amplitude decreased significantly in the St group and increased significantly in the Esc10 group compared with the Co group. In non‐stressed states, significant increases in slope and amplitude occurred in the Esc10 group compared with the Esc20 group. Notably, these values were also significantly enhanced by both escitalopram doses under stressed conditions. Moreover, serum corticosterone levels significantly elevated in the St group although its levels decreased in both St‐Esc groups compared with the St. Conclusion Stress significantly attenuated neural excitability and long‐term plasticity in the CA1 area. Only escitalopram 10 mg/kg improved synaptic excitability, as well as LTP induction and maintenance in non‐stressed subjects even more than normal levels. However, under stress conditions, both escitalopram doses enhanced neural excitability and memory probably due to reduced serum corticosterone levels.

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Interaction effect of crocin and citalopram on memory and locomotor activity in rats: an insight into BDNF and synaptophysin levels in the hippocampus

Nasseri,

Hajrasouliha,

Vaseghi

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Comparing the effects of crocin at different doses on excitability and long-term potentiation in the CA1 area, as well as the electroencephalogram responses of rats under chronic stress

Cited by 8 publications

References 44 publications

The Protective Effects of Crocin on Input-Output Functions and Long-term Potentiation of Hippocampal CA1 Area in Rats Exposed to Chronic Social Isolated Stress

The Protective Effects of Crocin on Input-Output Functions and Long-term Potentiation of Hippocampal CA1 Area in Rats Exposed to Chronic Social Isolated Stress

The protective effects of escitalopram on synaptic plasticity in the CA1 region of chronically stressed and non‐stressed male rats

Interaction effect of crocin and citalopram on memory and locomotor activity in rats: an insight into BDNF and synaptophysin levels in the hippocampus

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