Comparing the Effect of Garlic, Zataria multiflora and Clotrimazole Vaginal Cream 2% on Improvement of Fungal Vaginitis: A Randomized Controlled Trial

Farshbaf‐Khalili, Azizeh; Mohammadi-Ghalehbin, Behnam; Shahnazi, Mahnaz; Asghari, Soltan; Javadzadeh, Yousef; Azghani, Payman

doi:10.5812/ircmj.29262

Cited by 8 publications

(3 citation statements)

References 21 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The three most common vaginal infections in women are fungal, bacterial, and Trichomonas vaginitis (2). Vaginal infections can cause problems such as depres-sion, low self-esteem, dissatisfaction with life, high stress and decreased sexual intercourse, and infertility, so effective treatments are needed to eliminate these infections (3). A variety of chemical drugs are used to treat vaginitis in conventional medicine.…”

mentioning

confidence: 99%

Investigation of Antioxidant, Antifungal, Antibacterial, and Anti-inflammatory Effects of Teucrium polium on Common Pathogens in Vaginitis: A Review

Bardsiri

Moayedi

Meybodi

et al. 2022

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

Context: Pathological vaginal discharges are one of the most common reasons for referring to gynecological clinics. The use of herbal medicines has been considered as an effective and low-complication treatment method in recent years. In this study, we introduce Teucrium polium according to traditional Persian medicine and modern medicine’s point of view to investigate the antifungal, antibacterial, and anti-inflammatory effects of T. polium on common pathogens in vaginitis. Evidence Acquisition: This study is a simple review based on studies conducted in PubMed, Google Scholar, SID, and Scopus databases, from October 1984 to June 2019. Finally, 58 articles were selected from 88 for the final review. Results: The results indicate that T. polium is a potential source of antifungal, antibacterial, anti-inflammatory, and antioxidant in producing plant products for vaginal infections treatment thanks to its flavonoid compounds, sesquiterpenes, α-pinene, and linalool. Conclusions: Teucrium polium can be considered as a potential source for vaginal infection treatments. Much clinical research has not been conducted on its use in vaginal infection treatment, so it is recommended to conduct more clinical trials to prove the T. polium’s efficiency against common microorganisms in vaginitis and its treatment.

show abstract

mentioning

confidence: 99%

Investigation of Antioxidant, Antifungal, Antibacterial, and Anti-inflammatory Effects of Teucrium polium on Common Pathogens in Vaginitis: A Review

Bardsiri

Moayedi

Meybodi

et al. 2022

Jundishapur J Nat Pharm Prod

View full text Add to dashboard Cite

show abstract

“…There was no statistically significant difference between the two groups before and after the treatment of dyspareunia. In a study comparing the effect of thyme, garlic, and clotrimazole vaginal creams, there was no significant difference between the three groups after treatment [ 22 ]. Also, in another study, there was no significant difference between painful intercourse in the clotrimazole and the Satureja treatment group compared to the clotrimazole group [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis

et al. 2021

View full text Add to dashboard Cite

Candidal vaginitis has a relatively high prevalence, and its resistance to treatment is on the rise. Considering the complications of chemical drugs, the use of herbal medicines has now been favored due to the lack of changes in the normal vaginal flora. The aim of this study was to compare the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of candidal vulvovaginitis. A randomized clinical trial was conducted on 84 reproductive-aged women in the city of Ahvaz, Iran. Individuals were randomly divided into two treatment groups: 1% Satureja khuzestanica vaginal creams (n=42) and 1% clotrimazole vaginal cream (n=42) who used a one-full applicator daily for one week. About 4–7 days after the end of treatment, a clinical examination and laboratory re-tests were performed to determine the level of treatment. The data were analyzed using the Mann-Whitney U, t-test and Chi-square tests, with SPSS version 22. After the treatment, no significant difference was observed between the two groups in terms of vaginal discharge (p = 0.32), vaginal itching (p = 0.26), dysuria (p = 0.99) and dyspareunia (p = 0.60). Moreover, the results of culture (p = 0.62) and smear (p = 0.58) were not statistically significant in the two groups. Also, there was no significant difference between the two groups in terms of complete recovery after the treatment (p = 0.35). Satureja khuzestanica seems to have the same effect as clotrimazole in improving the symptoms of vaginal candidiasis, the negative results of culture and smear, as well as complete treatment.

show abstract

“…At least one episode of VVC can be experienced by 75% of all females in fertile age during their lifetime, of whom approximately 50% experience recurrent candidiasis. And almost 5% of infected females are resistant to treat-ment and spend a refractory period (2) that their quality of life and sexual health are influenced expressively (3,4).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Effect of Dill Seed Vaginal Cream, with a Persian Traditional Base, and 1% Clotrimazole Vaginal Cream on Vulvovaginal Candidiasis: A Double-Blind, Randomized Clinical Trial

Sarhadinejad¹,

Tajadini²,

Tansaz³

et al. 2018

Iran Red Crescent Med J

View full text Add to dashboard Cite

Background: Vulvovaginal candidiasis (VVC) is a very common debility in gynecology clinics. Despite access to several antifungal agents, VVC is still a challenge; therefore, presenting a novel antifungal agent, especially with a traditional origin, is of interest and demand. Objectives:The current study aimed at comparing the efficacy of Anethum graveolens L. (dill) vaginal cream with that of 1% Clotrimazole vaginal cream to treat VVC. Methods:A prospective, single-center, randomized, double-blind clinical trial was performed. In the current study, married females aged 18 -65 years, with probable vulvovaginal candidiasis were enrolled for primary evaluation. After VVC confirmation by the sniff test, the patients were allocated into three groups with regard to blocked randomization, and inclusion and exclusion criteria. The first group (n = 59) was treated with 1% Clotrimazole vaginal cream; the second (n = 60) with a combination of dill seed essential oil and dried aqueous extract vaginal cream (TEE); and the last (n = 56) with dill seed essential oil vaginal cream (EO) for seven nights. After 10 days, the therapeutic effects were assessed.Results: After the intervention, itching decreased to 30.5%, 3.3%, and 12.5% in the Clotrimazole, TEE, and EO groups, respectively; the sniff test also decreased to 33.9%, 13.3%, and 12.5%, respectively. Although a statistically significant difference, according to itching and sniff test, was observed among the three groups (P < 0.001, P = 0.005), there was no significant difference between TEE and EO (P = 0.06). Conclusions:The current study showed that the herbal preparation could be used as an alternative antifungal agent for vulvovaginal Candidiasis.

show abstract

Comparing the Effect of Garlic, Zataria multiflora and Clotrimazole Vaginal Cream 2% on Improvement of Fungal Vaginitis: A Randomized Controlled Trial

Cited by 8 publications

References 21 publications

Investigation of Antioxidant, Antifungal, Antibacterial, and Anti-inflammatory Effects of Teucrium polium on Common Pathogens in Vaginitis: A Review

Investigation of Antioxidant, Antifungal, Antibacterial, and Anti-inflammatory Effects of Teucrium polium on Common Pathogens in Vaginitis: A Review

Comparison of the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis

Comparing the Effect of Dill Seed Vaginal Cream, with a Persian Traditional Base, and 1% Clotrimazole Vaginal Cream on Vulvovaginal Candidiasis: A Double-Blind, Randomized Clinical Trial

Contact Info

Product

Resources

About