Comparing the Effect of Clomiphene Citrate and Letrozol on Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome

Najafi, Parisa; Noghabi, Saeid Pasban; Afzali, Narges; Mohammadzadeh, Sanaz

doi:10.5455/jpma.267607

Cited by 7 publications

(9 citation statements)

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“…When evaluated in terms of endometrial thickness, it was found to be 8.3±2.6 in the CC group and 11.8±2.7 in the letrozole group, and the difference between the two groups was considered statistically significant (p=0.001). 22 Pregnancy rates with letrozole ranged from 16-27.3% in several studies of similar size and type to ours, while pregnancy rates in the CC group ranged from 13-20.8%. Although pregnancy rates were high in the letrozole group, this increase was not statistically significant.…”

Section: Discussionsupporting

confidence: 70%

Efficacy of letrozole versus clomiphene citrate for infertile women with polycystic ovary syndrome

Birge

Bakır

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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Background: The aim was to compare ovulation induction protocols in anovulatory patients, who make up a significant percentage of infertility patients, and to determine the most appropriate treatment for patients in the clinic based on the findings.Methods: The effectiveness of clomiphene citrate (CC) and letrozole (aromatase inhibitor) in ovulation induction treatments were retrospectively compared in patients who applied for infertility in the last 5 years and were found to be anovulatory. 20 of these patients were being treated with clomiphene citrate, while the 18 were being treated with letrozole.Results: The study included a total of 38 anovulatory infertile patients. The mean age of the patients was found to be 29.3. When the endometrial thicknesses (ET) after the treatment were compared, the first group's mean EC was 6.1, while that of the second group was 9.05. The endometrial thicknesses measured after the treatments were found to be significantly different, which were consistent with other studies in the literature. Post-treatment ovulation responses were similar with 55% in both groups. In the evaluation of pregnancy outcomes, 20% of pregnancy was achieved in the first group and 33% in the second group.Conclusions: The use of letrozole, an aromatase inhibitor, may be suggested as an alternative to CC in the ovulation induction protocol in our clinical practice, particularly in obese patients.

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Section: Discussionsupporting

confidence: 70%

Efficacy of letrozole versus clomiphene citrate for infertile women with polycystic ovary syndrome

Birge

Bakır

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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“…There were 28 trials, 15,19–24,26–46 including 3,936 patients, that reported pregnancy. No heterogeneity between two groups was suggested ( P =.87, I 2 =0%); thus, a fixed-effects model was applied.…”

Section: Resultsmentioning

confidence: 99%

Letrozole Compared With Clomiphene Citrate for Polycystic Ovarian Syndrome

Liu

Geng

Huang

et al. 2023

Obstetrics &Amp; Gynecology

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To estimate the effect of letrozole and clomiphene citrate in women with infertility and polycystic ovarian syndrome (PCOS). METHODS OF STUDY SELECTION: MEDLINE throughPubMed, Web of Science, EMBASE, Cochrane Library, and ClinicalTrials.gov were searched for relevant studies from inception to February 1, 2022. Two reviewers retrieved, filtered, and extracted data independently using the bibliographic software EndNote X9 and Excel workbook. We included randomized controlled trials (RCTs) reporting ovulation induction outcomes in women with infertility and PCOS treated with either letrozole or clomiphene citrate followed by timed intercourse or intrauterine insemination. The data were merged into a mean difference or risk ratio (RR) with 95% CI, depending on variable types. TABULATION, INTEGRATION, AND RESULTS: Data collection and organization were conducted in accor-dance with the 2020 PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) statement. Twenty-nine RCTs were eligible, which included 3,952 women and 7,633 ovulation induction cycles. We acquired evidence from 22 RCTs for the ovulation rate, 28 RCTs for the clinical pregnancy rate, and eight RCTs for live-birth rate. Pooled analysis indicated that letrozole treatment prevailed against clomiphene citrate in ovulation rate (

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“…For patients with polycystic ovary infertility, in addition to ovulation induction, the fundamental purpose of the treatment is to improve the pregnancy rate. Letrozole [ 21 – 23 ] is a new type of ovulation induction drug, belonging to the third generation nonsteroidal aromatase inhibitors. Inhibition of aromatase blocks the synthesis and conversion of androgens to estrogens, thereby rapidly regulating androgen and estrogen levels in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome

Jiang

Tang

Sheng³

et al. 2022

Journal of Healthcare Engineering

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Background. Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder in women of gestational age and the most common cause of female infertility. This study aimed to investigate the effect of letrozole and metformin combined with targeted nursing on ovarian function, LH, and FSH in infertile patients with PCOS. Methods. A total of 72 infertile patients with PCOS were divided into the control group and combined group. The control group was given metformin tablets combined with targeted nursing therapy. The combined group was treated with letrozole on the basis of the control group. Ovarian function, LH, and FSH were compared between the two groups before and after treatment. Results. After treatment, the total effective rate (94.44%) of the combined group was significantly higher than that of the control group (80.56%). After treatment, the levels of HbA1c, FINS, HOMA-IR, TG, and TC in the two groups were lower than those before treatment, and the HDL-C level was higher than that before treatment. The full-term delivery rate, ovulation rate, and normal menstrual rate in the combined group were higher than those in the control group. After treatment, the LH level in the combined group was lower than that in the control group, and the FSH level was higher than that in the control group. After 1 month, 3 months, and 5 months of treatment, RI, PI, and ovarian volume were decreased, and the endometrial thickness was increased in both groups. Also, after 5 months of treatment, the RI, PI, and ovarian volume in the combined group were significantly lower than those in the control group, and the endometrial thickness was significantly higher than that in the control group. There was no statistically significant difference in the incidence of adverse reactions between the two groups. Conclusion. The combination of letrozole and metformin with targeted nursing in the treatment of infertility patients with PCOS has better clinical effect and high safety. It can improve endometrial receptivity and ovarian reserve function and regulate LH and FSH levels.

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Comparing the Effect of Clomiphene Citrate and Letrozol on Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome

Cited by 7 publications

References 0 publications

Efficacy of letrozole versus clomiphene citrate for infertile women with polycystic ovary syndrome

Efficacy of letrozole versus clomiphene citrate for infertile women with polycystic ovary syndrome

Letrozole Compared With Clomiphene Citrate for Polycystic Ovarian Syndrome

The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome

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